Study Shows Methyl B12 Benefit in Autism
Injectable methylcobalamin (B12) has been shown to improve the clinical status of patients through enhanced cell oxidative status and/or methylation capacity. In this study (2022), the benefits of a carefully developed syrup form of methylcobalamin was used as a treatment for autism. (Note: Methylcobalamin is the preferred form of B12 for supplementation versus cyanocobalamin, which is a synthetic form.)
For the study, methylcobalamin was administered daily at 500 µg (.5 mg) dose to 25 autistic children and young adults during a 200-day period with positive results. A link to the full report is included below.
Clinical and psychological status was evaluated by parents and psychologists and plasma levels of reduced and oxidized glutathione, vitamin B12, homocysteine, and cysteine were determined before the treatment, and at day 100 and day 200 of the treatment.
Good patient compliance was reported. Methylcobalamin treatment gradually improved the overall clinical and psychological status, with the highest impact in the social domain, followed by the cognitive, behavioral, and communication characteristics.
Changes in the clinical and psychological status were strongly associated with the changes in the level of reduced glutathione and reduced/oxidized glutathione ratio.
Conclusion: A high dose of methylcobalamin administered in syrup form improves the clinical and psychological status of autistic individuals, probably due to the improved oxidative status.
Additional Reading: Methyl B12 for Autism
Despite taking B12, I did not seem to be absorbing it. I was advised to switch to methyl B12, and that made all the difference. (This is not a case of autism, however).