kim

https://www.sciencedaily.com/releases/2016/05/160511105352.htm Too much folate in pregnant women increases risk for autism, study suggests Jan, your remarks made me think of this. I remember some being unimpressed with this research although I don't remember the specific criticism.

Have you read up on Hashimoto? I don't know much on the subject but I think anti-TG is a marker?

http://www.tandfonline.com/doi/abs/10.1080/21645515.2015.1062955?src=recsys Do vitamin D levels affect antibody titers produced in response to HPV vaccine? Those with lower vitamin D levels produced higher titers. Interesting. Taking a guess that TH1 might be suppressed and TH2 heightened in lower D individuals.

Don't want to hijack the topic but I have to point out something in that link under "multiple potential triggers," where vaccines are listed you see (eppur si muove) https://en.wikipedia.org/wiki/And_yet_it_moves

kakrpa, Have you read this from Dr. T? http://pandasinstitute.org/blog/2013/10/10-9-2013 I had never seen it before your post caught my attention. It doesn't go in depth but does mention low IgE/IgG4

Thanks for the update. Sure hope any negative effects disappear quickly. I've heard if antivirals are started fairly early on, it does seem to take some of the punch out. Personally, I would like to go the all natural route but not sure at this point. I don't even know if my kids would get shingles or chicken pox. They have had one dose only too. I know someone who got shingles in their late 40's. He decided not to take the Valtrex which had been prescribed. Dr. seemed puzzled that the case seemed as severe as it was (he didn't let on that he hadn't taken) so I'm assuming that it does help considerably with shingles. It would be appreciated if you could let us know how it progresses with your daughter. . We just can't afford to shut up anymore. No matter where you stand on vaccines or a particular vaccine, I just can't see too many people who want that choice taken out of their hands. I was reading this today. The paper won't be available until 2016 but the abstract makes you wonder if anyone knows what's going on. It seems the only thing that has been ruled out in relationship to autoimmunity/neuro disorders is vaccines. None of those vaxed vs unvaxed studies though, that would be unethical. How convenient. http://www.ncbi.nlm.nih.gov/pubmed/25484004 J Theor Biol. 2015 Jun 21;375:101-23. doi: 10.1016/j.jtbi.2014.11.022. Epub 2014 Dec 4. Unresolved issues in theories of autoimmune disease using myocarditis as a framework. Monarchcat, if you're reading did your kids do o.k? Did your son end up with CP?

Jan, I was wondering if the kids who don't show a response to steroids and seem not to respond or have a lot of problems with phama drugs/antibiotics, are in fact signaling a problem with this type of TH response. MDR1 function is something I would like to take a closer look at. More hours in a day please,lol. Here, we report that high-level IL23R expression within human memory T cells is restricted to a subset of CCR6+CXCR3hiCCR4loCCR10−CD161+ cells that selectively expresses the multi-drug transporter MDR1 (also known as P-glycoprotein [P-gp] and ABCB1). MDR1 is an ATP-dependent membrane efflux pump with broad substrate specificity best known for its role in promoting tumor resistance to chemotherapy (Gottesman et al., 2002). In nonmalignant cells, MDR1 is expressed on intestinal epithelium, endothelial cells of the blood-brain-barrier, and hepatocytes, where it controls the accumulation of xenobiotic compounds and exogenous pharmacologic molecules (Schinkel, 1997). MDR1 is also expressed in progenitor cell types, and is thought to play a role in the survival and longevity of these cells (Chaudhary and Roninson, 1991; Sincock and Ashman, 1997). Consistent with this, we show that a sizeable proportion of human MDR1+ Th17 cells also express the stem cell marker c-Kit. All c-Kit+ memory T cells display robust MDR1 activity, and these cells give rise to c-Kit−MDR1+ progeny after inflammatory T cell activation in the presence of IL-23. Both c-Kit+ and c-Kit− MDR1+ Th17 cells display unique pro-inflammatory characteristics, including production of Th17 and Th1 cytokines, reduced expression of IL-10 and other anti-inflammatory molecules, and hypersensitivity to IL-23 stimulation, where they display enhanced activation of STAT3 and marked up-regulation of IL-17A compared with MDR1− memory T cell subsets. Importantly, we show that c-Kit−CD161+MDR1+ Th17 cells are enriched and activated in CD patient lesions, and that MDR1+ Th17 cells are uniquely resistant to the anti-inflammatory actions of several glucocorticoids used to treat CD and other clinical autoimmune syndromes. Thus, MDR1 is a unique feature of pro-inflammatory and steroid-resistant Th17 cells in humans, which may be exploited to improve the diagnosis, characterization, and treatment of patients with chronic and steroid-resistant inflammatory diseases.

SFH, Can you update on how your daughter is doing with the shingles? If you're looking for a bright spot, those who get shingles at a younger age are supposed to be at much less risk for PHN (postherpetic neuralgia). They're finally admitting that the chicken pox vaccine is causing more shingles and at a younger age. I think the latest report says something about 30's? Then they point out the thing about younger age being assoc. with less PHN. My question is, what happens when a young woman gets this while pregnant? Are we working up to a shingles vaccine along with a flu vaccine and a Tdap while pregnant? How far do they think they can take this manipulation before we have even a worse situation on our hands than now, with all of these vaccines? will these young people end up with subsequent cases of shingles later? You can get it more than once. What strain is causing this, the wild or the vaccine strain? It just p's me off to no end!

The plot thickens on TH17 Resistant to steroids/ this type found in Crohn's/ interesting stuff/bolding mine http://jem.rupress.org/content/211/1/89.long Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of autoimmune inflammation. However, not all Th17 cells are pro-inflammatory. Pathogenic Th17 cells that induce autoimmunity in mice are distinguished from nonpathogenic Th17 cells by a unique transcriptional signature, including high Il23r expression, and these cells require Il23r for their inflammatory function. In contrast, defining features of human pro-inflammatory Th17 cells are unknown. We show that pro-inflammatory human Th17 cells are restricted to a subset of CCR6+CXCR3hiCCR4loCCR10−CD161+ cells that transiently express c-Kit and stably express P-glycoprotein (P-gp)/multi-drug resistance type 1 (MDR1). In contrast to MDR1− Th1 or Th17 cells, MDR1+ Th17 cells produce both Th17 (IL-17A, IL-17F, and IL-22) and Th1 (IFN-γ) cytokines upon TCR stimulation and do not express IL-10 or other anti-inflammatory molecules. These cells also display a transcriptional signature akin to pathogenic mouse Th17 cells and show heightened functional responses to IL-23 stimulation. In vivo, MDR1+ Th17 cells are enriched and activated in the gut of Crohn’s disease patients. Furthermore, MDR1+ Th17 cells are refractory to several glucocorticoids used to treat clinical autoimmune disease. Thus, MDR1+ Th17 cells may be important mediators of chronic inflammation, particularly in clinical settings of steroid resistant inflammatory disease.

PR40, When I read the article that you linked, I noticed this one as I started clicking around that site. Thanks for posting. http://www.medicalnewstoday.com/articles/152822.php?trendmd-shared=0 Hydrangea Root Shows Promise In Treating Autoimmune Disorders An exciting new area in the field of autoimmune disease research is learning about the role of a particular immune system cell called the T helper 17 (Th17) which is genetically different from other types of CD4+ T cell like the Th1, Th2 and T-regulatory cells and appears to play a unique role in the part of the immune system that causes harm when it over-reacts.

I'm reading of missing signatures and possible tampering. Does anyone from Cal. have any info?

http://www.nih.gov/news/health/aug2015/nei-18.htm In uveitis, bacteria in gut may instruct immune cells to attack the eye

This is a young man's account (video) of a younger age of onset with later increase in symptoms and PANS diagnosis. http://pandasnetwork.org/latest-news/page/28/

Mumofthree, I have to ask. Is there a chance that this girl was in the process of the Gardasil/HPV series. It seems that highly athletic people are more prone to adverse events with that vaccine in particular. Her story sounds a lot like others that I have read in relationship to a bad out come with that vax.

I have donated already and I hope others from other states will too. Was anyone else astounded that Carson made the remarks that he did during the debate? I knew Trump's stance, although I was not impressed with his remarks but my mouth fell open when Carson chimed in.

Sirena, Have you looked at the wiki page on oxycodone? https://en.wikipedia.org/wiki/Oxycodone This looked interesting; After oxycodone binds to the opioid receptor, a G-protein complex is released, which inhibits the release of neurotransmitters by the cell by reducing the amount of cAMP produced, closing the Ca++ channels, and opening the K channels.[26] I see you refer to your son as PANDAS and with the T&A and antibiotics, I'm assuming that his symptoms started after strep/multiple strep infections? One of my favorite posters here (Buster,) made a remark regarding cAMP that I never really understood in relationship to abnormal antibody response to strep. You can read his post here. 2nd one down. http://latitudes.org/forums/index.php?showtopic=5683&page=3 more from wiki https://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate#Role_of_cAMP_in_prefrontal_cortex_disorders Role of cAMP in prefrontal cortex disorders Recent research suggests that cAMP affects the function of higher-order thinking in the prefrontal cortex through its regulation of ion channels called hyperpolarization-activated cyclic nucleotide-gated channels (HCN). When cAMP stimulates the HCN, the channels open, closing the brain cell to communication and thus interfering with the function of the prefrontal cortex. This research, especially the cognitive deficits in age-related illnesses and ADHD, is of interest to researchers studying the brain.[6] I don't really have any idea if there is anything useful here or not and I realize how complicated this stuff is but if you play around with any of this and come up with something, let us know

Looks like they are doing a study on Miralax safety in kids http://commonhealth.wbur.org/2015/01/miralax-dilemma-parents-safe Miralax Dilemma: As Common Laxative Studied, Parents Ask, ‘Is It Safe? https://www.gutsense.org/gutsense/the-role-of-miralax-laxative-in-autism-dementia-alzheimer.html Back in December of 2011, the FDA placed MiraLAX — a polyethylene glycol-containing blockbuster drug marketed by Merck & Co — on its Adverse Event Reporting System (AERS) in connection to “neuropsychiatric events.”

from the link above http://journals.plos...al.pone.0101257 Antibiotic Treatment Attenuates Behavioral and Neurochemical Changes Induced by Exposure of Rats to Group A Streptococcal Antigen More on B. fragilis http://www.thedoctorwillseeyounow.com/content/autoimmune/art3294.html http://www.caltech.edu/article/13412 04/21/2011 Learning to Tolerate Our Microbial Self excerpt underlined by me From that vantage point, the bacteria are able to orchestrate control over the immune system—and, specifically, over the behavior of immune cells known as regulatory T cells, or Treg cells. The normal function of Treg cells is to prevent the immune system from reacting against our own tissues, by shutting down certain immune responses; they therefore prevent autoimmune reactions (which, when uncontrolled, can lead to diseases such as multiple sclerosis, type 1 diabetes, lupus, psoriasis, and Crohn's disease). Bacteroides fragilis has evolved to produce a molecule that tricks the immune system into activating Treg cells in the gut, but in this case, Mazmanian says, "the purpose is to keep the cells from attacking the bugs. Beautiful, right?" In their Science paper, Mazmanian and colleagues describe the entire molecular pathway that produces this effect. It starts with the bacteria producing a complex sugar molecule called polysaccharide A (PSA). PSA is sensed by particular receptors, known as Toll-like receptors, on the surfaces of Treg cells, thus activating those cells specifically. In response, Treg cells suppress yet another type of cell, the T helper 17 (Th17) cells. Normally, Th17 cells induce pro-inflammatory responses—those that would result, for example, in the elimination of foreign bacteria or other pathogens from the body. By shutting those cells down, B. fragilis gets a free pass to colonize the gut. "Up until now, we have thought that triggering of Toll-like receptors resulted solely in the induction of pathways that eliminate bacteria," says Round. "However, our studies suggest that multiple yet undiscovered host pathways allow us to coexist with our microbial partners."

. that is my understanding too. Searching f/h, can you spare my computer eyeballs some stress and explain how these shots are given? Is it after the 1st pregnancy, during the 2nd or what? excerpt from http://thinkingmomsrevolution.com/the-thompson-transcripts-shocking-revelations-by-the-cdc-whistleblower/ Dr. Thompson then brings Dr. Hooker’s attention to the SEED project, which he refers to as “Disneyland” (of data), and how this data set contains the health records of some 1200 children, 800 of which are confirmed autistic, with complete vaccination records, including prenatal vaccines and RhoGAM shots. This data has yet to be released to the public for study. In fact, according to Dr. Thompson, “it is under lock and key.” However, as Dr. Thompson says, “So far there is about sixty proposals in, um, for people ready to do studies. Not a single one of them looks at vaccines, not one!” He is clearly outraged by this when he recounts how he asked his colleagues “What are you going to say when you have twelve hundred autism cases and a bunch of controls and you never looked at vaccines and you have all their vaccine records?” Dr. Thompson describes the SEED data as a “. . . gold mine. That’s the mother-load of mother-loads (sic). Because it doesn’t matter what Insel does.” He is referring to the promise Thomas Insel, chairman of the Interagency Autism Coordinating Committee, made to Rep. Bill Posey in a congressional hearing that took place on May 20, 2014, that a study comparing health outcomes of vaccinated children with those of unvaccinated children would be done. It has not been done. Interestingly, according to Thompson, “The CDC was invited to testify [at that hearing] and they declined” and “. . . Coleen (Boyle) said that she would never go and testify again.

Just a FYI http://www.lawyershop.com/practice-areas/personal-injury/dangerous-drugs/vaccines/rhogam/thimerosal When Did RhoGAM® Contain Thimerosal?The RhoGAM® treatment that is currently being produced does not contain thimerosal. Patients who have been raising concern about the dangerous side effects of RhoGAM® use during pregnancy received the treatment between 1968 and 2001. These individuals claim that the ADHD and DSI symptoms their children are presently exhibiting are rooted in their prenatal exposure to mercury. RhoGAM® lawyers are presenting these cases and pushing for further investigation into ethylmercury.

lbee, This is an archived page so I don't know how old these are. http://www.recoveringkids.com/#!archives/c1lso In the old days, parents were mostly trying to get rid of thimerosal (50% ETHYL mercury) from vaccines. You may be dealing with methyl mercury. Has anyone identified the source? Do you live near a coal fired power plant by chance? Here is a site with some ideas. http://www.co.thurston.wa.us/health/ehhm/mercury.html This says methyl mercury has a 1/2 life in blood of about 44 days http://emedicine.medscape.com/article/1175560-workup#c7. I'm wondering if the repeat blood work stayed he same or came down? Did the hair test reveal high/low levels? Sorry for all of the questions. I know you are looking for success stories but I hope you will share as much as you feel comfortable with as it may help someone else. At one time, I was fairly "up" on Andy Cutler's chelation protocol. That might be a place where you could learn some of the details to discuss with the Dr. who is going to treat your daughter. This site and the links within might be helpful. http://www.regardingcaroline.com/andycutler2.html

another response to the video. Wakefield talked about the experiment with the high potency Edmonston Zagreb measles vaccine. I don't think he mentioned that it was illegally given to babies in Los Angeles too. Read this page on how they were trying to overwhelm the maternal antibodies (and consider where we're heading with chicken pox/varicella) and how the parents weren't told. http://www.nvic.org/nvic-archives/newsletter/vaccinereactionjune1996.aspx

I wanted to comment on a couple of things that he touched on. I had contacted a pharmacy in April of 2006 to see if single MMR was available for a pregnant relative. As you can see for roughly $120.00 parents could have split up the vaccines. They took away our option (in the US) for using the single injections sometime after that too April 06 As the senators introducing sweeping bills for mandatory vaccination with their "proven safe and effective BS," we have the Merck case with again no coverage. If these senators are so worried about infectious disease outbreaks, why the silence? http://www.chicagotribune.com/news/local/breaking/ct-mumps-outbreak-university-of-illinois-met-0805-20150804-story.html Mumps outbreak at University of Illinois leads to call for re-immunizational Let's say these University students go in a get the two available meningitis vaccines, a flu shot, gardasil, an MMR, maybe a Tdap that they were missing, what would happen to them? I wonder how many they will "catch" as they head in for their 3rd MMR? reminder http://www.courthousenews.com/2012/06/27/47851.htm "This was the same mumps strain with which the children were vaccinated," the complaint states. That "subverted" the purpose of the testing regime, "which was to measure the vaccine's ability to provide protection against a disease-causing mumps virus that a child would actually face in real life. The end result of this deviation ... was that Merck's test overstated the vaccine's effectiveness," Chatom claims. Merck also added animal antibodies to blood samples to achieve more favorable test results, though it knew that the human immune system would never produce such antibodies, and that the antibodies created a laboratory testing scenario that "did not in any way correspond to, correlate with, or represent real life ... virus neutralization in vaccinated people," according to the complaint. Chatom claims that the falsification of test results occurred "with the knowledge, authority and approval of Merck's senior management." And as Merck's vaccine is the only game in town, the vaccine's "significantly degraded" quality means "there has remained a significant risk of a resurgence of mumps outbreaks," Chatom says in its complaint. It claims that the degraded quality of the Merck vaccine played a role in a 2006 mumps outbreak in the Midwest, and in another outbreak in 2009. Between Thompson and Merck how are these bills even being introduced?

You had mentioned a UTI in your first post, and the positive response to amoxicillin. I wanted to point out something from the study that I linked in last post about antibiotics/GAS . It seems that this bacterial balance is gaining more and more attention.