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kim

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  1. https://www.sciencedaily.com/releases/2016/05/160511105352.htm Too much folate in pregnant women increases risk for autism, study suggests Jan, your remarks made me think of this. I remember some being unimpressed with this research although I don't remember the specific criticism.
  2. kim

    Thyroid Question.

    Have you read up on Hashimoto? I don't know much on the subject but I think anti-TG is a marker?
  3. http://www.tandfonline.com/doi/abs/10.1080/21645515.2015.1062955?src=recsys Do vitamin D levels affect antibody titers produced in response to HPV vaccine? Those with lower vitamin D levels produced higher titers. Interesting. Taking a guess that TH1 might be suppressed and TH2 heightened in lower D individuals.
  4. kim

    Low IgE and IgG4

    Don't want to hijack the topic but I have to point out something in that link under "multiple potential triggers," where vaccines are listed you see (eppur si muove) https://en.wikipedia.org/wiki/And_yet_it_moves
  5. kim

    Low IgE and IgG4

    kakrpa, Have you read this from Dr. T? http://pandasinstitute.org/blog/2013/10/10-9-2013 I had never seen it before your post caught my attention. It doesn't go in depth but does mention low IgE/IgG4
  6. Thanks for the update. Sure hope any negative effects disappear quickly. I've heard if antivirals are started fairly early on, it does seem to take some of the punch out. Personally, I would like to go the all natural route but not sure at this point. I don't even know if my kids would get shingles or chicken pox. They have had one dose only too. I know someone who got shingles in their late 40's. He decided not to take the Valtrex which had been prescribed. Dr. seemed puzzled that the case seemed as severe as it was (he didn't let on that he hadn't taken) so I'm assuming that it does help considerably with shingles. It would be appreciated if you could let us know how it progresses with your daughter. . We just can't afford to shut up anymore. No matter where you stand on vaccines or a particular vaccine, I just can't see too many people who want that choice taken out of their hands. I was reading this today. The paper won't be available until 2016 but the abstract makes you wonder if anyone knows what's going on. It seems the only thing that has been ruled out in relationship to autoimmunity/neuro disorders is vaccines. None of those vaxed vs unvaxed studies though, that would be unethical. How convenient. http://www.ncbi.nlm.nih.gov/pubmed/25484004 J Theor Biol. 2015 Jun 21;375:101-23. doi: 10.1016/j.jtbi.2014.11.022. Epub 2014 Dec 4. Unresolved issues in theories of autoimmune disease using myocarditis as a framework. Monarchcat, if you're reading did your kids do o.k? Did your son end up with CP?
  7. Jan, I was wondering if the kids who don't show a response to steroids and seem not to respond or have a lot of problems with phama drugs/antibiotics, are in fact signaling a problem with this type of TH response. MDR1 function is something I would like to take a closer look at. More hours in a day please,lol. Here, we report that high-level IL23R expression within human memory T cells is restricted to a subset of CCR6+CXCR3hiCCR4loCCR10−CD161+ cells that selectively expresses the multi-drug transporter MDR1 (also known as P-glycoprotein [P-gp] and ABCB1). MDR1 is an ATP-dependent membrane efflux pump with broad substrate specificity best known for its role in promoting tumor resistance to chemotherapy (Gottesman et al., 2002). In nonmalignant cells, MDR1 is expressed on intestinal epithelium, endothelial cells of the blood-brain-barrier, and hepatocytes, where it controls the accumulation of xenobiotic compounds and exogenous pharmacologic molecules (Schinkel, 1997). MDR1 is also expressed in progenitor cell types, and is thought to play a role in the survival and longevity of these cells (Chaudhary and Roninson, 1991; Sincock and Ashman, 1997). Consistent with this, we show that a sizeable proportion of human MDR1+ Th17 cells also express the stem cell marker c-Kit. All c-Kit+ memory T cells display robust MDR1 activity, and these cells give rise to c-Kit−MDR1+ progeny after inflammatory T cell activation in the presence of IL-23. Both c-Kit+ and c-Kit− MDR1+ Th17 cells display unique pro-inflammatory characteristics, including production of Th17 and Th1 cytokines, reduced expression of IL-10 and other anti-inflammatory molecules, and hypersensitivity to IL-23 stimulation, where they display enhanced activation of STAT3 and marked up-regulation of IL-17A compared with MDR1− memory T cell subsets. Importantly, we show that c-Kit−CD161+MDR1+ Th17 cells are enriched and activated in CD patient lesions, and that MDR1+ Th17 cells are uniquely resistant to the anti-inflammatory actions of several glucocorticoids used to treat CD and other clinical autoimmune syndromes. Thus, MDR1 is a unique feature of pro-inflammatory and steroid-resistant Th17 cells in humans, which may be exploited to improve the diagnosis, characterization, and treatment of patients with chronic and steroid-resistant inflammatory diseases.
  8. SFH, Can you update on how your daughter is doing with the shingles? If you're looking for a bright spot, those who get shingles at a younger age are supposed to be at much less risk for PHN (postherpetic neuralgia). They're finally admitting that the chicken pox vaccine is causing more shingles and at a younger age. I think the latest report says something about 30's? Then they point out the thing about younger age being assoc. with less PHN. My question is, what happens when a young woman gets this while pregnant? Are we working up to a shingles vaccine along with a flu vaccine and a Tdap while pregnant? How far do they think they can take this manipulation before we have even a worse situation on our hands than now, with all of these vaccines? will these young people end up with subsequent cases of shingles later? You can get it more than once. What strain is causing this, the wild or the vaccine strain? It just p's me off to no end!
  9. The plot thickens on TH17 Resistant to steroids/ this type found in Crohn's/ interesting stuff/bolding mine http://jem.rupress.org/content/211/1/89.long Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of autoimmune inflammation. However, not all Th17 cells are pro-inflammatory. Pathogenic Th17 cells that induce autoimmunity in mice are distinguished from nonpathogenic Th17 cells by a unique transcriptional signature, including high Il23r expression, and these cells require Il23r for their inflammatory function. In contrast, defining features of human pro-inflammatory Th17 cells are unknown. We show that pro-inflammatory human Th17 cells are restricted to a subset of CCR6+CXCR3hiCCR4loCCR10−CD161+ cells that transiently express c-Kit and stably express P-glycoprotein (P-gp)/multi-drug resistance type 1 (MDR1). In contrast to MDR1− Th1 or Th17 cells, MDR1+ Th17 cells produce both Th17 (IL-17A, IL-17F, and IL-22) and Th1 (IFN-γ) cytokines upon TCR stimulation and do not express IL-10 or other anti-inflammatory molecules. These cells also display a transcriptional signature akin to pathogenic mouse Th17 cells and show heightened functional responses to IL-23 stimulation. In vivo, MDR1+ Th17 cells are enriched and activated in the gut of Crohn’s disease patients. Furthermore, MDR1+ Th17 cells are refractory to several glucocorticoids used to treat clinical autoimmune disease. Thus, MDR1+ Th17 cells may be important mediators of chronic inflammation, particularly in clinical settings of steroid resistant inflammatory disease.
  10. PR40, When I read the article that you linked, I noticed this one as I started clicking around that site. Thanks for posting. http://www.medicalnewstoday.com/articles/152822.php?trendmd-shared=0 Hydrangea Root Shows Promise In Treating Autoimmune Disorders An exciting new area in the field of autoimmune disease research is learning about the role of a particular immune system cell called the T helper 17 (Th17) which is genetically different from other types of CD4+ T cell like the Th1, Th2 and T-regulatory cells and appears to play a unique role in the part of the immune system that causes harm when it over-reacts.
  11. I'm reading of missing signatures and possible tampering. Does anyone from Cal. have any info?
  12. http://www.nih.gov/news/health/aug2015/nei-18.htm In uveitis, bacteria in gut may instruct immune cells to attack the eye
  13. This is a young man's account (video) of a younger age of onset with later increase in symptoms and PANS diagnosis. http://pandasnetwork.org/latest-news/page/28/
  14. Mumofthree, I have to ask. Is there a chance that this girl was in the process of the Gardasil/HPV series. It seems that highly athletic people are more prone to adverse events with that vaccine in particular. Her story sounds a lot like others that I have read in relationship to a bad out come with that vax.
  15. I have donated already and I hope others from other states will too. Was anyone else astounded that Carson made the remarks that he did during the debate? I knew Trump's stance, although I was not impressed with his remarks but my mouth fell open when Carson chimed in.
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