kim

This explains how different antibiotics are thought to be involved in immunomodulation Current Molecular Pharmacology, 2008, 1, 68-79 Immunomodulatory Properties of Antibiotics http://www.bentham.org/cmp/samples/cmp%201-1/Nau.pdf

This one looks really interesting but I can't make much of it past the title as it was really making my head hurt I won't mention any names, but I know we have at least on poster here that is familiar with tyrosine hydroxylase and this person is very smart, so maybe he'll tell us if this has any significance in a situation of upregulated tyrosine converting to too much dopamine? (EAmom....will flattery work?) http://www.kinaseresearch.com/showabstract.php?pmid=2901463 Inactivation of tyrosine hydroxylase activity by ascorbate in vitro and in rat PC12 cells.

Stephanie, Do you know how to search SFmom's posts? She has the best info on the possible Kawasaki connection. I think many of us are searching for the connection to illness that seem to mimick PANDAS symtoms. MycoP, Lyme, etc. It's very confusing for parents with kids that seem to have no known strep history (SFmom points out that Kawasacki has been linked to strep in at least one study, I believe) or have exacerbations with other illness. Your remarks are interesting, regarding family members and your brother''s illness with Kawasaki

David A. Geier Mark R. Geier Toxicological & Environmental Chemistry, Volume 92(5):1025-103? May 2010. http://www.informaworld.com/smpp/content~d...tent=a921813911 The effects of methylcobalamin (vitamin B12) injection (75 µg kg-1) on cobalt levels in autism spectrum disorders (ASDs) and potential toxic effects of cobalt on human neurons were evaluated. http://mercury-freedrugs.org/docs/100430_P...obaltLevels.pdf An autism cohort study of cobalt levels following vitamin B12 injections

http://www.pediatricsupersite.com/view.aspx?rid=63822 The researchers determined that development of Kawasaki disease in later childhood was connected to the following factors: Maternal age of 35 years and older (OR=1.65; 95% CI, 1.20-2.27) Mother born outside of the United States (OR=1.36; 95% CI, 1.06-1.76). Maternal group B streptococcal colonization (OR=0.52; 95% CI, 0.26- 0.97).

Some of us have struggled with the question of overactivating the immune system as opposed to suppression when autoimmunity is suspected. I think it's important to look at the big picture (to the best of our ability) I thought this was one good example. bold mine http://www.kinaseresearch.com/showabstract.php?pmid=11120850 Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activate http://www.biomol.de/wiki/index.php/NF-kap...bitory_Peptides NF-kappaB has been shown to regulate the expression of a number of genes whose products are involved in inflammation, viral replication, carcinogenesis, anti-apoptosis, invasion, and metastasis. Vit C given to bowel tolerence during illness like H1N1 was recommended by someone with an opinion that I trust a lot. Many of the complications that are seen with illness (pneumonia, Flu etc.) are the result of inflammation, not an overwhelming invasion by the pathogen (my understanding).

Michael, You might want to read thru this thread. I pretty much have the same feelings that nevergiveup expressed. http://www.latitudes.org/forums/index.php?...amp;#entry60548 I hope this works out for you tho, with no adverse effects. Could you keep us posted on that please?

from Teresa Binstock Preorder - out in MAY IN US http://www.amazon. com/exec/ obidos/ISBN= 1616081694/ wellwithinA/ Callous Disregard: Autism and Vaccines: The Truth Behind a Tragedy *Andrew J. Wakefield* (Author) IN UK - don't see it on Amazon.co.uk yet *Conspiracy - or ruthless pragmatism? How the vaccine apparatchiks and medical self-interest groups deal with dissent. *The subject is autism; the suspect is childhood vaccines. This is the account of how a doctor confronted first a disease, and then the medical system that sought and still seeks to deny that disease, leaving millions of children to suffer and a world at risk. /"Do not judge me too harshly Dr. Wakefield, but when I die I am taking my son with me. You see, I?m all he has. I?m the only one who loves him." / /- A mother?s plea in 1997 / In 1995 Wakefield came to a fork in the road. As an academic gastroenterologist at the Royal Free School of Medicine and the University of London, Wakefield was presented with a professional challenge and confronted by a moral choice. Previously normal children were, according to their parents, regressing into autism and developing intestinal problems - many parents blamed the MMR vaccine. Trusting in his medical training, parental narrative, and above all, the instinct of mothers for their children?s wellbeing, he chose the hard road. Walk that road now, here; some already have - the parents of affected children. Many will, either as parents or grandparents, as the worldwide tsunami of childhood developmental disorders break hearts and bankrupts educational and healthcare infrastructures. Wakefield provides the facts, an explanation of the problem that confronted him and his colleagues 15 years ago. He does this in a detailed forensic analysis of the lies, obfuscation, cover ups, and the dystopian science and medicine that panders to commercial interest at the expense of your children. *About Dr. Wakefield * Dr Andrew Wakefield, MB, BS, FRCS, FRCPath, is an academic gastroenterologist. He received his medical degree from St. Mary?s Hospital Medical School (part of the University of London) in 1981, one of the third generation of his family to have studied medicine at that teaching hospital. He pursued a career in gastrointestinal surgery with a particular interest in inflammatory bowel disease. He qualified as Fellow of the Royal College of Surgeons in 1985 and in 1996 was awarded a Wellcome Trust Traveling Fellowship to study small-intestinal transplantation in Toronto, Canada. He was made a Fellow of the Royal College of Pathologists in 2001. He has published over 130 original scientific articles, book chapters, and invited scientific commentaries. In the pursuit of possible links between childhood vaccines, intestinal inflammation, and neurologic injury in children, Dr. Wakefield lost his job in the Department of Medicine at London?s Royal Free Hospital, his country, his career, and his medical license. He is married to Carmel, a physician and a classical radio presenter. They have four children, James, Sam, Imogen, and Corin, and a black mongrel called Bella. This post may be forwarded hither & yon

Thanks Vickie for posting and a big thanks to AOA! A great write up to print for our Drs

I thought you might get at least a little satisfaction out of this Let me ask you something. My kids were repeatedly treated with amox. sometimes 3 times hand running. Do you think a stubborn attitude regarding the ability of amox. to clear strep in some kids contributed to an increase in PANDAS situations? Any thoughts on how that would fall into the "untreated," category? It must be very frustrating to understand the ins and outs of all of this and have to read these "lame" studies that grab the headline. Most of us can't see what you do, until you explain. It reminds me so much of the "vaccine info." Parents and medical professionals alike, do the same thing on vax discussion sites. The ones that have the ability, point out why it's FLAWED, yet the general public is led to believe something totally different, time and time again. I know you are in the midst of trying to get your daughter well and helping many others along the way, but someday maybe we will see you with your own blog taking some to task! If you have a chance, please take a look at Hilary's butt kicking response. I think we have another clear example of someone who understands too much, reaching a boiling point. I think you'll relate. http://www.beyondconformity.co.nz/_blog/Hi...nd_big_porkies/ OPEN LETTER : Dear Drs Michael Osterholm, Kris Ehresmann and Ed Belangia; None of you get it, do you? You say you “know the idea that the flu vaccine doesn't prevent deaths in the elderly sounds almost blasphemous” and that you “didn't really want to believe it at first either,” but that the new research is “incontrovertible”? The new research is no less “incontrovertible” than the research done between 1960 and 1976, which showed exactly the same - and Dr J Anthony Morris’s honesty, lost him his job in FDA. Can’t nuke the bread-and-butter of all vaccines, the annual flu-vax till ringer! And yes, that’s what was said! Pardon the sarcasm in this post, but I’ve got a thirty year itch that needs a darned good scratch.

http://www.neurology.org/cgi/eletters/WNL....1bd10fdv1#40606 Streptococcal infection, Tourette syndrome, and OCD: Is there a connection?

Where did Offit come up vaccines adding 30 years to lifespan? Anyone know of any such data? I was looking for some of the charts that I have seen over the years and saw this article apparently written in response to the segment being discussed. http://www.healthsentinel.com/joomla/index...l&Itemid=24 check out the graphs The Vaccine War: A Forgotten History

Nancy, I'm glad you posted that remark. I was so disgusted with the first 5 minutes, I just clicked out. Didn't know if they ever got to any good material from "the other side," or not, but just couldn't take it. Yea, we forgot about the disease's. That's the reason that the majority of us vaccinated. Has anyone ever seen this email? http://www.putchildrenfirst.org/media/2.7.pdf These are the people that we are supposed to trust? That blackened area at the top says "It just won't go away." There is another that talks about ways to dumb down the #'s. No matter where thimerosal falls in the whole scheme of things, once you see the way things happen behind the scenes and the "no harm studies," you just don't really care what these people have to say. We NEED INDEPENDENT STUDIES. No CDC, IOM, PHARMA etc. involvement

Peglem, I ran across this quite by accident, but I thought it might be helpful for those of you dealing with IVIG. I am so praying for strength for you and your Ddaughter This say last updated 2007...so not sure if there are changes to any of this? http://www.ashp.org/s_ashp/docs/files/DSho...pdatedDec07.pdf Intravenous Immune Globulins (IVIG) Side-by-Side Comparison

Stephanie, I was curious if they are still using the french lab for the porphyrin test and if you have treated your son for high metals or is that not an issue for him?

pixiemommy, I hope you and your family are doing well. I only read this thread today, or I would have mentioned this earlier. I have read some personal accounts of people who had tendon problems (including rupture) while taking cipro. I hope it's going ok for you, but please be extra cautious with any pain that might arise. http://www.webmd.com/news/20080708/fda-war...rupture-tendons FDA Warning: Cipro May Rupture Tendons Agency Issues 'Black Box' Warning for Antibiotics Known as Fluroquinolones

worriedmommy, When your daughter said "checking" things, are you sure she didn't mean that she was checking for joint pain, stiffness or tingling feelings? Recently, I have come to the conclusion that some things that I always thought of as tics, really aren't. Some eye movements for instance are because of dry eye feelings, like widening and probably what many would consider to be an eye roll. If your daughter's hands looked somewhat clawlike with rigid movements toward her palms, I would ask her if her fingers hurt or feel stiff. Just thought this might be a possibility. bronxmom, I hope your son's sensation passes quickly!

When I had the psoriasis associated rash (skin infection most likely strep) first I had hyperpigmentation followed by hypopigmentation. This is routinely discussed on a psoriasis website in regards to guttate psoriasis. I sure am a believer in auto antibodies causing disruption here. I just referred to tyrosine hydroxylase in another thread, and have been interested in the possibility of N acetyl glucosamine being helpful in the treatment of some types of auto immune disease. This was something that I found very interesting bolding mine http://www.pgbeautygroomingscience.com/index.php?id=267 Topical Formulation Containing N-Acetyl Glucosamine and Niacinamide Reduces the Appearance of Hyperpigmented Spots on Human Facial Skin Glucosamine has been shown to reduce production of melanin in melanocyte cell culture [1]. The reported mechanism is inhibition of maturation of tyrosinase, specifically inhibiting the glycosylation of pro-tyrosinase to active tyrosinase. Clinical pigmentation effects of topical glucosamine have not been reported. We have investigated the effectiveness of a stable derivative of glucosamine, N-acetyl glucosamine (NAG), alone and in combination with a previously demonstrated effective material, niacinamide (N) [2], for clinically reducing the appearance of facial hyperpigmented spots L-Phenylalanine is involved in production skin pigment melanin. L-phenylalanine> L tyrosine> L dopa> dopamine

Hey, hey now Mr. Buster , you made me go back and rethink tyrosine hydroxylase (i was looking at skin stuff and you pointed out the connection with CamK and dopamine) now your messing with me throwing tryptophan in here too. So it looks like CaM k activates tyrosine hydrox/ andtryptophan hydrox, correct? Now this speaks of post synaptic density and the hippocampus/forebrain, but still http://www.bioreagents.com/products/produc...?catnbr=MA1-048

Nancy. WAY TO GO! It takes so much orgainization and energy to do what you did (educated a med proff). Could I have a go at the Dr. that gave you the vaccine brush off?

Peglem, I had an article saved that I think expands just a little on the abstract that you posted Scientists ID a single sugar that allows antibodies to fight inflammation This seems to beg the question of what are they trying to accomplish with IVIG? In Momto2's cases, she wants to clear an infection, would low dose be a better option? From 2nd abstact above...this is the part I'm really curious about too .

Did anyone ever look at Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy? http://www.ncbi.nlm.nih.gov/pubmed/18951069 The articles to the right are worth reading too. Susan, if there is any connection here, I think you're right on with different things being able to set off "anti bodies behaving badly." I have not seen droopy eye lids, but these symptoms of children falling down, limb weakness etc, possibly gastrophresis (?) make me wonder. Rapid onset of severe autonomic failure, with orthostatic hypotension don't fit the bill, but gastrointestinal dysmotility, bladder dysfunction, sicca symptoms, impaired pupillary light reflex? Might be something there for some of our kids?? fiveam, I'm sure Dr. Latimer, being a neuro will be very sensitive to any visable symptoms. You could always ask her if she thinks there is any correlation

I would really recommend that you call the office and go and get a copy of the results or have them faxed to you. Then ask questions here, or start researching what those highs and lows could mean. I don't want to add to your anxiety and don't know how likely this might be, but thought you might want to take a look at this. Seems like these transient neuromuscular symptoms go right over most Dr.s heads when they are present! http://www.nlm.nih.gov/medlineplus/ency/article/003035.htm Both eyelids drooping: Medical problem, such as myasthenia gravis http://www.nlm.nih.gov/medlineplus/ency/article/000712.htm Myasthenia gravis If you feel that there are medical issues that are going unaddressed, keep at those straws!

It was shared from another group that comes to my email. I was just passing it on, but you're all welcome! I wish there was a way to thank the family that did the amazing job of documenting and sharing everything that they did.

Momto2, Do you know if monthly IVIG will eventually clear any immune complexe? I couldn't really find much regarding that? I quickly read thru this (kind of an overview of what an immune complex is) and saw this at the end. BTW...congratulations on the booger retrieval yesterday, lol. Funny what can bring tremendous joy to a parent http://www.uchsc.edu/immuno/cohen/PDF%20fi...7630%202009.pdf TREATMENT in all these conditions is anti-inflammatory and sometime immunosuppressive. If a patient has hives (urticaria), they may be a result of the anaphylatoxic release of histamine, and respond to antihistamine treatment. In the worst cases, plasmapheresis (removal and replacement of plasma with return of red and white blood cells) can be very helpful as a temporary measure.