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Buster

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Buster last won the day on February 23 2016

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  1. There are several great places to donate depending what your focus is. I donate to two groups: pandasppn.org and pandasnetwork.org. Pandasppn.org focuses on sponsoring clinical research and research grants associated with pans/pandas - it's more focused on medical professionals. Pandasnetwork.org sponsors research, research symposiums, and provides parent support services and outreach. Buster
  2. According to dr Swedo, The cell line that had the d8/17 marker died out. It appeared promising but no longer practical.
  3. That's a good point. The current FAQ is very PANDAS specific rather than being PANS/PANDAS and PITANDS partitioned. I'll try a version partitioned and see.
  4. Hi folks, I've been going through the various papers and trying to tease out what questions the researchers are actually answering. If you've been reading papers you think are signfiicant can you add to this list or send me a message regarding other questions/papers? I'm not looking for "review" articles, but rather people running experiments that are testing certain hypothesies. Whether sudden onset OCD is correlated with untreated strep infections? [swedo1997] S Swedo et al, "Identification of Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With St
  5. Will do. I'll update that section.
  6. Just a note that I updated the Frequently Asked Questions (FAQ) at http://www.latitudes.org/forums/index.php?showtopic=6266 I'll make another pass at it tomorrow to bring in more of the research of the last 2 years. Buster
  7. Hi, Leckman is an extremely reasonable doctor and has seen now first hand the PANDAS kids. He didn't retract his prior papers (which is a shame, but has said publically that he didn't think he had PANDAS kids in his prior trials and instead had kids with Tourettes who met most (if not all) the PANDAS criteria as interpreted at the time). He frankly thought sudden onset or episodic course was a throw away line as it applied to any tic because they all have sudden onset and wax/wane. It took him seeing a PANDAS kid before, during, and after an exacerbation to understand how different t
  8. Here's a reference to the original work. Heard about it today on NPR: Lancet article
  9. It's hard to tell if mitral valve preceded other symptoms, however, if you have ocd, movement disorder and mitral valve involvement, it sure sounds like underlying acute rheumatic fever . About 30% with arf get monoPhasic Sydenham chorea. About 20% with arf develop OCD (typically those who have sc) thinkIng of you, Buster
  10. My understanding is that the auto-antibodies in PANDAS bind with D1 and D2 receptors. One of the sphincters in the bladder/urinary tract is also controlled by D2 receptors. Apparently, the auto-antibodies accidentally relax the sphincter. Buster
  11. Well there's a current clinical study looking at the relationship between Vitamin D and hypercholesterolemia. My gut is she's likely vitamin D deficient and pretty stressed out. I'll be interested in the test results. http://clinicaltrials.gov/ct2/show/NCT00723385 Buster
  12. Hi folks, I've seen a bunch of traffic about whether PANS replaces PANDAS. It does not. I checked with Dr. Swedo and with Dr. Leckman. PANDAS remains a research criteria and there is considerable scientific support for the association with streptococcal infections as well as support for the broader PITAND criteria due to H1N1, mycoplasma pneumonia, etc. You might be asking "why if there is good scientific evidence do we have three criteria rather than one". Well.... The reason for creating PANS as a new set of criteria was to enable epidemiology studies. Dr Swedo writ
  13. LOL, we all know if its in Wikipedia it must be true! I should mention that I spent months trying to move the Wikipedia article (basically because of a single "editor"). On controversial topics, there are apparently some "rules" for the editors: You need to cite review articles and not original research -- apparently to prevent incorrect interpretation You need to cite review articles that have been out for a while -- otherwise it's too recent You can't connect material from different articles -- this is considered original research You can imagine with PANDAS that this i
  14. There was a paper Feb 2010 by Leckman and Kaplan titled "The Human Immune Response to Streptococcal Extracellular Antigens: Clinical, Diagnostic, and Potential Pathogenetic Implications." (see http://cid.oxfordjournals.org/content/50/4/481.full) that also found a considerable failure of ASO to rise in documented and controlled experiments. The big statement is: "Of the previously mentioned 58 new GAS acquisitions, 36 (62.1%) were associated with a significant increase in ASO and/or ADB titer. However, only 28 of these acquisitions were associated with an increase in ASO and 28 wit
  15. Yes. Take a look at this thread: http://www.latitudes.org/forums/index.php?showtopic=3756&st=0#entry29305 In 2003 by Shet and Kaplan found that ASO rises in 53% of patients with culturable strep (i.e., about the same as a coin flip). Buster
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