

kim
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Why my son may have recovered so fast on Flagyl
kim replied to Phasmid's topic in PANS / PANDAS (Lyme included)
Fixit, No, the skin infection came after I had the psoriasis on my elbow for many years. The psoriasis actually disappeared after the infection. Maybe? What I thought was interesting was the fact that this is the first evidence (?) I have seen where these problematic antibodies were recognizing yeast. The same epitope that has been shown to be problematic in PANDAS (GlcNAc). -
Please do let us know. I didn't pay a lot of attention to the other causes. I would just cut and paste the list that you provided and voted. Now, I'm thinking about narcoplepsy and a few others that probably have some overlap with PANDAS research. Besides, I think I kinda got addicted to the sound of that can opening and pouring (signing in and out multiple times). Thought I never wanted to hear it again, but now, I think I'll miss it
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Kelly ,Vickie and everyone who took time to participate with votes .....Congratulations and THANK YOU!!! This is really amazing. So proud to be a part of a forum with such wonderful dedicated people (both here and TS forum).
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I was holding off voting, but they're in now. We couldn't possibly get knocked all the way out at this point could we? Since it isn't televised (that was cute), I'm heading over to Phasmid's thread to try to answer a question that fixit left. I'm sure by the time I leave a confusing story that takes me 3 hours to post, I'll have missed the whole celebration. Will someone come over and get me, please
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Deeana, I just wish we had the info. to make right decisions. Seems we have a lot of people with auto immune illness, yet no good studies on the effects of vaccination as opposed to natural infection. How can that be? Look at that schedule and how many vaccines there are. Now look for studies involving children with known/ recognized autoimmune/inflammatory illness. There should be some good info right? Try to find it. Also, if you look at what happened with Prevnar, there have been different strains than what were commonly causing infection that are popping up and causing problems (some are highly antibiotic resistant). So now they're adding 6 more strains to the original 7. If I believe the vax is going to offer my child protection from one strain, am I increasing the odds that they will be infected with another? I'm thinking about the menningitis vaccine here. Will the vaccine hype up my childs immune response or suppress it (vaccines have been shown to do both at different time frames). Will they be more susceptable to other illness after the vaccine, for how long? These are only some of the questions that I don't believe have good answers!
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Why my son may have recovered so fast on Flagyl
kim replied to Phasmid's topic in PANS / PANDAS (Lyme included)
Phasmid, I think this is very important too. I found some research in relationship to psoriais/ strep that I find pretty interesting (and believe it may well be what happened to me after a skin infection). If this is correct, it seems these antibodies may be stirred up by fungus or yeast, too. http://www.ncbi.nlm.nih.gov/pmc/articles/P...ei0105-0079.pdf Antibodies from patients with psoriasis recognize N-acetylglucosamine terminals in glycoproteins from Pityrosporum ovale. -
Dee, Sorry, I'm making a complicated subject worse for you. Somehow, I thought you mentioned diphtheria in your last post. I think you know they are talking about the meningitis vaccine and the TdaP now.
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Dee, Look up the package insert on Menactra. Menactra used for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y and W-135 You know how I said above that aluminum is used to stimulate an immune response? From above "Diphtheria Toxoid Conjugate Vaccine" They join the vaccine components to diptheria to kick up the immune response. It's the same with Prevnar. The babies (i think it's under two) weren't responding to pneumonia vaccines the way adults did. So they added the diphtheria and aluminum and golly gee, they got antibodies.
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Check out the ad for that vaccine....notice the line under the 2nd picture? http://www.adacelvaccine.com/index.cfm?FA=...mp;P=HowS_pread It is unknown whether immunizing adolescents and adults against pertussis will reduce the risk of transmission to infants. This SIXTH combo of DtaP/ TDaP/DPT etc. is being recommended for exactly that reason Peg. Babies are still getting Pertussis. I suspect there have been many cases in older kids too, which were probably diagnosed as asthma. If the kid was fully immunized it couldn't be Pertussis right? I had a Dr. tell me this herself. She said she had to take swabs and prove to the CDC that it was Pertussis. How well has this vax ever worked? It wasn't dangerous (annoying yes) to the older children, but they didn't belong on a steroid for asthma either. It was pertussis. As far as the tetanus part goes, I read in one of the vax inserts that the annual incidence of tetanus in the US was around 560 (that's close not exact) prior to widespread routine use of the vaccine. The package insert for the vax in the ad above says protection from the tetanus portion generally lasts for 10 years. If you look at the vax schedules, would your child even need the tetanus portion yet (assuming you believe the benefit out ways the risk of the vaccine). 5th dose 4-6 years 6th dose 11-12 years 0-6 years http://www.cdc.gov/vaccines/recs/schedules...schedule-pr.pdf 7-18 years http://www.cdc.gov/vaccines/recs/schedules...schedule-pr.pdf This vaccine contains aluminum as an adjuvant (immune system booster). No one really knew how that worked. Recently, a team figured out that it was activating inflammasomes. Hummmm...could that be a problem for some? I could go on and on, but I'm rusty on this subject to begin with, so I'll stop here. I do hope that every parent does some research in this area. We need parents to understand what's going on here, and make their Dr.s accountable for knowing what they're talking about when they push these vaccines. We also need reactions reported!!!!! These are some excerpts from an article that I had saved. When I read the supposed adverse events #'s reported after widespread use of a new vaccine, I almost want to laugh or vomit depending on the day. I know how hard it is to get an adverse event recognized as being linked to a vaccine. 'You have to Google Guillain-Barre.'" It was against the rules, for fear of feeding a patient's anxiety, but the nurse checked. "Within two hours, a new doctor was doing tests and checked me into the hospital." http://checkorphan.getreelhealth.com/grid/...-s-rare-illness According to his neurologist, Mr. Pehanic said the cause for his case is unknown. "I think that my neurologist suspected that the numerous vaccines I had in a short period of time may have sent my immune system into overdrive," he said. * * * * * * In September, Mr. Pehanic and his wife, Stacie, who live in Broadview Heights, had been preparing to travel to China on Oct. 28 to adopt Chloe. They both had vaccines for hepatitis A and B, tetanus and typhoid, and they had a seasonal flu shot. * * * * * * Mr. Pehanic's doctor advised him to see a psychiatrist. "She saw me twice and thought it was a conversion disorder," in which no physical reason can explain the paralysis. "She told me that the mind does weird things to the body and I started to believe that," he said. The psychiatrist prescribed anti-anxiety drugs, "but I felt no anxiety," he said. "We had been planning the adoption for three years." In fact, the Pehanics had applied for a child with special needs to speed up the process. Chloe has a cleft lip and palate, which are scheduled to be corrected by surgery later this month. "Eventually, the psychiatrist put me into the emergency room and checked me into a psychiatric ward. They took my shoes, shoelaces and sweat-pants string." That happened on Oct. 15. "At this point, I couldn't walk and was in a wheelchair. I was there a few days and went to group therapy. No one was allowed to talk to me because that could feed a patient's anxiety." * * * * * * * * "It was frustrating," he said. "You know it's not anxiety, but no one was listening." He remembered what he had read about Guillain-Barre in a pamphlet when getting his vaccinations. "On Oct. 17, I finally wheeled myself to the front desk," he said. That task was difficult because the numbness had moved up to his arms. He could not even grip a pen or write his name. "I said to the nurse, 'You have to Google Guillain-Barre.'" It was against the rules, for fear of feeding a patient's anxiety, but the nurse checked. "Within two hours, a new doctor was doing tests and checked me into the hospital." A spinal tap confirmed that he had Guillain-Barre, he said. "From that point on, it was a matter of time. I was so happy. At least I knew what it was and what it wasn't."
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info about probiotics containing strep
kim replied to AmberM's topic in PANS / PANDAS (Lyme included)
I don't really have an opinion on this, just a couple of thoughts. From the statement above To the best of my knowledge, N acetylglucosamine has been shown to be the reactive epitope in the cell wall of S Pyrogenes that causes the cross reactivity with human tissue. Looking at this statement regarding S thermophilus makes me wonder... http://microbewiki.kenyon.edu/index.php/St...us_thermophilus Ok, s thermophilus does contain NAG in it's cell wall too, but would antibodies that are coded for s pyrogens necessairly attack s thermophilus? Then this statement Does s thermophilis adhere (colonize)? If antibodies do recognize it, what happens in a gut devoid of s thermophilis? Could this a problem with the ability to break down casein? -
You guys have been amazing in getting this effort up and over the top !!! THANK YOU ! Couldn't agree more! I'm voting away here, including making sure I got passwords for those who were out of town this past weekend, so I could vote for them.
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That was sure good for a laugh For anyone who is still having freeze problems, just wanted to say that I stay away from the link with PANDAS in the title. I just go to pepsirefresheverything.com and copy the list into the search box. If I go near the PANDAS page, it freezes right away. I'm voting for several people, so the freezing is was a real problem. I'm sure praying this can be done this month
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familyof4, Thanks for sharing that. Do you remember what prompted the Dr. to order the test? Do you remember what test showed the insufficiency? Was it a reg Ped or a DAN/alternative Dr.?
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Kelly, It pops right up when I click on it. If you copy and paste the title, the page with the links will come right up and you can access from there, if it won't work for you.
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Kelly, There maybe something useful here? http://www.journals.uchicago.edu/doi/pdf/10.1086/513807 HLA-DR Class II Associations with Rubella Vaccine–Induced Joint Manifestations edit...the reference articles may be more helpful
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basically dut, yes. That's the way I'm reading it I wanted to point these out too, since I know we have families that have dealt with glomerulonephritis http://www.ncbi.nlm.nih.gov/pubmed/3310414 In vivo degradation of immune complexes in the kidney by orally administered enzymes http://www.ncbi.nlm.nih.gov/pubmed/17846774 Infection and glomerulonephritis
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dut, I have been meaning to spend some time on this subject too. What seems really interesting is the relationship btwn enzymes and immune complex degradation. Some older reasearch (read abstracts off to the right too) Enzyme breakdown of immune complexes http://www.ncbi.nlm.nih.gov/pubmed/6606278 The Houston enzymes that we were using a few years back contain papain (peptizyde..can be ordered with or without papain). The involvement of cleavage of the immune complex by papain /trypsin seems well worth looking at. BTW, I really appreciated the article that you posted on the bbb on another thread. I got a few interesting things out of that. Didn't have the time to comment after I got done with it but for those of you that are posting those types of articles don't be discouraged if the isn't a big response. It doesn't mean others aren't finding useful info in them. Keep posting!
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wornoutmom, I'm sorry that your Dr. wasn't more specific. I hope others who have been down this path will have some info on the prednisone, altho it sounds like you may be past the worst of it? I'm sure the use of tylenol isn't your biggest concern right now, but I thought I would leave this for anyone who wants to weed through the info. The sulfur pathways are of particular interest to me, and we no longer use acetaminophen here at all. I'm sure everyone appreciates you sharing your son's experience here, and pray you see good results. don't know about the contribution to the autism epidemic, but still some good info on why to keep the use of this stuff to a minimum http://www.thorne.com/altmedrev/.fulltext/14/4/364.pdf
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lynn, PCV (pneumococcal conjugate vaccine) wasn't around until the year 2000. I think your son was too old to have received the series? There is good discussion on this subject here http://www.latitudes.org/forums/index.php?...c=6469&st=0 Notice Busters comment
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I thought this was a pretty interesting regarding the effect of Glucosamine sulfate in treatment of uveitis In Buster's thread titled Coolest paper on how T-cells cross BBB, New Nature paper http://www.latitudes.org/forums/index.php?...c=6063&st=0 He pointed out how ICAM 1 seemed to be involved in the T cells crossing the BBB Paper on uveitis http://www.iovs.org/cgi/content/full/49/12/5441 Inhibitory Effects of Glucosamine on Endotoxin-Induced Uveitis in Lewis Rats PURPOSE. Glucosamine sulfate (GS) is a naturally occurring sugar that exerts immunosuppressive effects in vitro and in vivo. The authors investigated whether GS modulates the inflammatory reaction in endotoxin-induced uveitis (EIU) of rats and the mechanisms by which it exerts its effects. and RESULTS. Cell counting and analysis of protein concentration in aqueous humor revealed that GS suppressed EIU in rats treated with a high dose of GS (1000 mg/kg). Immunohistochemistry showed that treatment with GS reduced ICAM-1 expression and suppressed activation of NF-B in the iris-ciliary body. The main inflammatory cells in the iris-ciliary body during EIU were macrophages. In LPS-stimulated macrophage RAW cell culture, GS inhibited the production of NO and PG-E2, the expression of iNOS and COX-2, and the activation of NF-B. CONCLUSIONS. GS suppresses EIU in rats by blockading the NF-B–dependent signaling pathway and the subsequent production of ICAM-1 and proinflammatory mediators. This study has extended the authors’ previous observation that GS is a potentially important compound for reducing ICAM-1–mediated inflammatory effects in the eye.
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http://jn.nutrition.org/cgi/content/full/134/1/149 Balb/cA mice were used to study the in vivo effect of N-acetyl cysteine, S-allyl cysteine, S-ethyl cysteine, S-methyl cysteine and S-propyl cysteine, all derived from garlic, on glutathione (GSH) concentration and catalase and glutathione peroxidase (GPX) activities in plasma, kidney and liver. Increased dopamine initially with a decrease later....1 mouse year approx 34 human years? Free Radic Biol Med. 2008 Jul 15;45(2):193-200. Epub 2008 Apr 15. MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels. Oien DB, Osterhaus GL, Latif SA, Pinkston JW, Fulks J, Johnson M, Fowler SC, Moskovitz J. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA. Abstract Oxidative stress can cause methionine oxidation that has been implicated in various proteins malfunctions, if not adequately reduced by the methionine sulfoxide reductase system. Recent evidence has found oxidized methionine residues in neurodegenerative conditions. Previously, we have described elevated levels of brain pathologies and an abnormal walking pattern in the methionine sulfoxide reductase A knockout (MsrA(-/-)) mouse. Here we show that MsrA(-/-) mice have compromised complex task learning capabilities relative to wild-type mice. Likewise, MsrA(-/-) mice exhibit lower locomotor activity and altered gait that exacerbated with age. Furthermore, MsrA(-/-) mice were less responsive to amphetamine treatment. Consequently, brain dopamine levels were determined. Surprisingly, relative to wild-type mice, MsrA(-/-) brains contained significantly higher levels of dopamine up to 12 months of age, while lower levels of dopamine were observed at 16 months of age. Moreover, striatal regions of MsrA(-/-) mice showed an increase of dopamine release parallel to observed dopamine levels. Similarly, the expression pattern of tyrosine hydroxylase activating protein correlated with the age-dependent dopamine levels. Thus, it is suggested that dopamine regulation and signaling pathways are impaired in MsrA(-/-) mice, which may contribute to their abnormal behavior. These observations may be relevant to age-related neurological diseases associated with oxidative stress.
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This post was copied from another thread..... I had posted some info on a thread that Peglem started regarding CaMKs. It seemed where heart injury or arrythmia's were concerned that methionine was involved with elevated CaMK. One article said something like "the loss of two neighboring methionines," which I didn't understand at all. It said if these methionines were "lost," that CaM kinase would return to it's normal state. Recently I ran across a diagram that I thought might explain it. It shows where calmodulin, after undergoing transformation by the addition of calcium, has "unmasked," or exposed methionine. Some of the other articles on that thread seemed to show where something called MSRA (S-Methyl-L-Cysteine), would protect cells against damage from oxidation (ok I'm getting lost...have to go find the thread and read this AGAIN) but one study talked about MSRA being found abundantly in garlic, beets, and cabbage. This study was in regards to Parkinson's, which made me think about the tremors that some seem to experience. I, myself had had periods of irregular heartbeats for years, and my oldest son has mentioned it a few times during illness and also a "tremory," feeling. I"m taking orgainic garlic caps right now and continuing to look for new info in this area. Just wondered if anyone thought this was as interesting as I do! Here's the diagram of calmodulin http://www.pdb.org/pdb/static.do?p=educati...th/pdb44_2.html I think these are the key articles from that thread with one that I just found thrown in. I had these saved, so I'll have to read them myself to see if they are the ones that I think they are http://www.medicalnewstoday.com/articles/106098.php Study Identifies New Mechanism Linking Activation Of Key Heart Enzyme And Oxidative Stress http://www.jneurosci.org/cgi/content/abstract/27/47/12808 Methionine Sulfoxide Reductase A and a Dietary Supplement S-Methyl-L-Cysteine Prevent Parkinson's-Like Symptoms http://www.ncbi.nlm.nih.gov/pubmed/20374422 Dopamine D receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse
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So happy to read your update. Let us know when he has the surgery, prayers are always available from here. I'm so glad that you see a good summer ahead, where you will get a little R&R too.
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Since you all are discussing the heart involvement, I was wondering if anyone would take a look at something that has me quite intrigued (if anyone has any brain cells that they can spare today...I'm not too comfortable relying on my own anymore ). I had posted some info on a thread that Peglem started regarding CaMKs. It seemed where heart injury or arrythmia's were concerned that methionine was involved with elevated CaMK. One article said something like "the loss of two neighboring methionines," which I didn't understand at all. It said if these methionines were "lost," that CaM kinase would return to it's normal state. Recently I ran across a diagram that I thought might explain it. It shows where calmodulin, after undergoing transformation by the addition of calcium, has "unmasked," or exposed methionine. Some of the other articles on that thread seemed to show where something called MSRA (S-Methyl-L-Cysteine), would protect cells against damage from oxidation (ok I'm getting lost...have to go find the thread and read this AGAIN) but one study talked about MSRA being found abundantly in garlic, beets, and cabbage. This study was in regards to Parkinson's, which made me think about the tremors that some seem to experience. I, myself had had periods of irregular heartbeats for years, and my oldest son has mentioned it a few times during illness and also a "tremory," feeling. I"m taking orgainic garlic caps right now and continuing to look for new info in this area. Just wondered if anyone thought this was as interesting as I do! Here's the diagram of calmodulin http://www.pdb.org/pdb/static.do?p=educati...th/pdb44_2.html This is the thread that Peglem started with the articles that I was referencing Peg's CaMKs thread http://www.latitudes.org/forums/index.php?...l=Cam+Kinase+II I think these are the key articles from that thread with one that I just found thrown in. I had these saved, so I'll have to read them myself to see if they are the ones that I think they are http://www.medicalnewstoday.com/articles/106098.php Study Identifies New Mechanism Linking Activation Of Key Heart Enzyme And Oxidative Stress http://www.jneurosci.org/cgi/content/abstract/27/47/12808 Methionine Sulfoxide Reductase A and a Dietary Supplement S-Methyl-L-Cysteine Prevent Parkinson's-Like Symptoms http://www.ncbi.nlm.nih.gov/pubmed/20374422 Dopamine D receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse
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I just voted too and sent out emails for others who were voting last time with the new instructions. IT IS SO MUCH EASIER!