kim

mayzoo, Have you found anything out on your daughter's tests? Praying you find answers quickly.

dasu, It's too bad that they didn't put a bunch of vaccines around that ice cream cone. When I saw they were looking at Polysorbate 80, it immediately made me think of the vaccine excipients. The discussion of it's use in vaccines has mostly been concern over it's effects on the bbb. http://www.naturalnews.com/043710_vaccines_toxins_blood_brain_barrier.html http://www.researchgate.net/publication/14224946_Nanoparticles_and_microparticles_for_drug_and_vaccine_delivery Heres the link where you can find which ones have it Vaccine Excipient & Media Summary Excipients Included in U.S. Vaccines, by Vaccine http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf these are some that contain it Human Papillomavirus (HPV) (Gardasil) Influenza (Fluarix) PREVNAR 13 Rotavirus (RotaTeq) sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, vero cells[DNA from porcine circoviruses (PCV) 1 and 2 has been detected in RotaTeq. PCV-1 and PCV-2 are not known to cause disease in humans. DTaP Tdap (Boostrix)

Sonshine, Have you found this paper yet? It looks like this has some good infomation on the challenge vaccination results. http://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20and%20Parameters/Diagnostic-vaccination-in-PID-2012.pdf Use and interpretation of diagnostic vaccination in primary immunodeficiency: A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology this may or may not be helpful with the negative varicella result http://www.cdc.gov/vaccines/pubs/pinkbook/varicella.html

Thank you missionmama for posting. Nancy, Cythia Janak has done a lot of work on the HPV vaccine. You can see the documents on her site here (how they used alum placebo) http://www.renewamerica.com/columns/janak/080723 The new slap in the face today is how they are organizing their big plans to get "we the adults," into the profit pool on a larger scale. http://memoryholeblog.com/2015/02/21/us-government-moves-on-nationwide-adult-vaccination/ February 21, 2015 US Government Moves on Nationwide Adult Vaccination When I say slap in the face i'm referring to the way they are ramming the changes in state laws through as a result of the measles cases, with so many concerns and unanswered questions including a CDC scientists saying yet again, the study design was altered to cover up an unwanted finding. Just scroll through this page. You may see changes in the works for your own state. https://nvicadvocacy.org/members/Home.aspx Our children are already having their right to an education threatened. Now our teachers, healthcare professionals Notice it's not just measles or polio, but the whole schedule.

Sonshine, Have you read these threads? I think Buster has some papers on one of these threads that might be helpful? http://latitudes.org/forums/index.php?showtopic=5167 http://latitudes.org/forums/index.php?showtopic=5167&page=1 PREVNAR 13 http://latitudes.org/forums/index.php?showtopic=11319 This doesn't relate to your question but it is interesting for those reading on the subject http://www.ncbi.nlm.nih.gov/pubmed/15385481 Limited Role of Antibody in Clearance of Streptococcus pneumoniae in a Murine Model of Colonization

BJ47, I know you are probably hoping to connect with people with tics and low CD57 but the remarks (106 comments) from this site seem to have some people with good info on CD 57 in regards to lyme. http://www.medhelp.org/posts/Lyme-Disease/What-else-causes-low-CD57/show/772748 Since CD4 and CD8 are discussed in some of the remarks too, you might want to look at this http://www.biologicalpsychiatryjournal.com/article/S0006-3223%2806%2900804-3/abstract Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study I hope someone on this forum has some input for you and welcome.

Just thought I would share what looks like a reasonble explaination for this http://www.sciencedirect.com/science/article/pii/S0264410X12007761 Review of the United States universal varicella vaccination program excerpt from 12. Safety of varicella and HZ vaccinations 12.1. Complications of introducing the vaccine- or Oka-strain varicella zoster virus (VZV) Consider a child that is administered the live Oka-strain varicella vaccine and is subsequently exposed to an individual shedding VZV—either: (a) a child with varicella or HZ infection or ( an adult with HZ infection. If the VZV strains are sufficiently heterologous (genetically distinct), a second case of varicella can result. There are at least five VZV genotype variations or virus clades known at this time, in addition to 4 rarely-reported provisional clades.

pr40 It looks like they are talking about the inactivated flu vaccination here (as opposed to the live vaccine) Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+ T Cell Immunity in Children Some parents feel that "no more live viral vaccines," are the better way to go and have been advised against them by their phsycians. And this Study shows cytokine storm in fatal 2009 H1N1 cases http://www.cidrap.umn.edu/news-perspective/2013/08/study-shows-cytokine-storm-fatal-2009-h1n1-cases How does this work in people who get the inactivated flu vaccine and then get the flu or a flu like virus anyway? Is there an enhanced inflammatory response? I'm just throwing these things out as I'm finding the things that I want to reread. Another article to consider Study finds flu shot really did make people sicker http://metronews.ca/health/363279/canadian-problem-maybe-not-study-finds/

Posting this on the run so will be interested to see if what I think I'm reading here is what anyone else interested makes of it Vaccine-induced CD4 T cells have adverse effect in a mouse model of infection http://medicalxpress.com/news/2015-01-vaccine-induced-cd4-cells-adverse-effect.html Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+ T Cell Immunity in Children http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209321/

http://www.ageofautism.com/2015/01/recent-italian-court-decisions-on-vaccines-and-autism.html Recent Italian Court Decisions on Vaccines and Autism

Jan, ?????? http://www.sciencedaily.com/releases/2008/05/080501125455.htm http://www.jneurosci.org/content/27/47/12808.abstract Methionine Sulfoxide Reductase A and a Dietary Supplement S-Methyl-L-Cysteine Prevent Parkinson's-Like Symptoms Furthermore, we demonstrate that one way to enhance the MSRA antioxidant system is dietary supplementation with S-methyl-L-cysteine (SMLC), found abundantly in garlic, cabbage, and turnips. SMLC, I think a Dr. (lab) that measures CaMKII was supposed to have said that it was unknown what CaMKII levels looked like in nomal children with strep, so I'm going to venture a guess that it's more of a correlation at this point. I found it interesting to see the results of high CaMKII in kids that didn't have the classic overnight onset of symptoms too (the few that I knew of that didn't really identify with the PANDAS profile). Something that stood out of something that you linked above Read Buster's response here http://latitudes.org/forums/index.php?showtopic=5683&page=3 He kind of lost me with the remark about cAMP which may tie in with what 911rn just posted regardiing COQ10 (effects on ATP) from wiki on cAMP (just interesting) http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate Role of cAMP in prefrontal cortex disorders

Tiger, That is not a strange question at all. I'm thinking that most on the forum probably don't realize that calpol is acetaminophen. I think you will find that the geneal concenses is that ibuprofen is the preferred NSAID if you are going to use one, due to it's reputation of being anti inflammatory. Acetaminophen also depletes glutathione and sulfur levels. My family strictly avoids it now. You might find this interesting to read through regarding Acetaminophen http://www.biomedsearch.com/article/Did-acetaminophen-provoke-autism-epidemic/215514457.html I'm going to let parents that are certain they are dealing with a pandas/pans situation give you suggestions there. editing to add a link that i thought was very important when discussing fever and skin infection http://whale.to/a/butler_chickenpox.html

Patents http://www.google.com/patents/WO1993014766A1?cl=en Use of n-acetyl glucosamine for the treatment of food allergy

from that same study If primary repair is not then possible, fibroblasts alter their matrix secretion pattern in response to macrophage cytokines to produce collagens, resulting in scarring.1, 13, 17 Is that not thought to be what occurs in heart valve damage in Rheum fever?

Jan, Since I'm not familiar with Buhner I looked here http://www.rain-tree.com/myco.htm#.VHsDtMlYBic a forum discussing his protocol has this excerpt http://www.roadback.org/forum/viewtopic.php?f=1&t=9499&start=10 So it does look like he's talking about replacing stuff that the myco P is using up. I agree! I sure hope there are favorable results with the GlcNAc trial, but there is the vitamin D aspect and more there. I have to wonder where proper sulfation fits in too? BTW..did DS's IgG food testing include any breakdown of IgG antibodies (subclasses) ? . It's been a long time since I looked at any of this. I'm reading the pros and cons of IgG food testing and some of this is quite interesting. pro http://www.greatplainslaboratory.com/home/eng/food_allergy_igg.asp#totalvs4 In specific immunotherapy with allergen in allergic rhinitis, for example, increases in allergen-specific IgG4 levels indeed correlate with improved clinical responses. IgG4 antibodies not only block IgE mediated food allergies but also block the reactions of food antigens with other IgG subclasses, reducing inflammatory reactions caused by the other IgG subclasses of antibodies to food antigens. con http://www.foodallergy.org/diagnosis-testing/unproven-testing?

Wow http://www.lymeneteurope.org/forum/viewtopic.php?f=6&t=3921 and Jan I was reading the other thread on this forum that you had originally linked and totally missed what Pr40 and rowingmom had posted. I googled a little and found similiar articles, sure could explain some unusual reactions around here (allergy type response to what appears to be a bacterial infection). If this can happen btwn lyme and meat, seems it could happen in other infections. One of my kids tested IgE high to almost all of the grains. Wheat Germ Agglutinin binds N acetyl glucosamine, so that has always kinds of stuck in the back of my mind. I have also read that it (WGA) can cross the BBB and take other things with it. I guess I'm really just trying to digest the fact that the body can develope an allergy response to a sugar. Let me complicate this just a little further. I'm not linking this because of anything to do with a vaccine, just thought the mention of interesting. Not sure that has anything to do with anything, just something that I had saved http://www.ncbi.nlm.nih.gov/books/NBK6309/ When you asked I was wondering if it's the amino acids in the meat that needs to be replaced. I remember reading where one of the DAN dr.s talked about getting the "jelly," that cooks out of meat into kids (that was a long time ago and I can't remeber who said it). Are you thinking along the same lines as we discussed with N acetyl glucosamine, as in bind a receptor (beneficial) or avoid an irritant?

Jan, where is that article?

missmom, I know that a parent reported/suspected this at some time in the past because I remember looking at some of this info before. I think I was focused on atropine at that time and looking at this again, it doesn't look like that is the first choice. It seems as though the reactions would be more likely in a theraputic or ongoing dosage, but who knows. You may want to find out exactly what they used to dilate and do a little sleuthing. http://www.aapos.org/terms/conditions/43 Dilating Eye Drops (the drug pictured above) http://www.drugs.com/cdi/cyclogyl.html Use Cyclogyl with extreme caution in CHILDREN because they may be more sensitive to its effects, especially behavioral changes. and Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in behavior (especially in children), including clumsiness, confusion, difficulty walking, disorientation, hallucinations, hyperactivity, restlessness, seizures, or slurred speech. Two other substances mentioned http://en.wikipedia.org/wiki/Atropine In general, atropine counters the "rest and digest" activity of glands regulated by the parasympathetic nervous system. This occurs because atropine is a competitive antagonist of the muscarinic acetylcholine receptors (acetylcholine being the main neurotransmitter used by the parasympathetic nervous system). Atropine dilates the pupils, increases heart rate, and reduces salivation and other secretions. and Topical atropine is used as a cycloplegic, to temporarily paralyze the accommodation reflex, and as a mydriatic, to dilate the pupils. Atropine degrades slowly, typically wearing off in 7 to 14 days, so it is generally used as a therapeutic mydriatic, whereas tropicamide (a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic agonist) is preferred as an aid to ophthalmic examination. http://en.wikipedia.org/wiki/Phenylephrine Phenylephrine is a sympathomimetic drug, which means that it mimics the actions of epinephrine (commonly known as adrenaline) or norepinephrine. Phenylephrine selectively binds to alpha receptors which cause blood vessels to constrict. Phenylephrine may cause side effects such as headache, reflex bradycardia, excitability, restlessness and cardiac arrhythmias. Phenylephrine is not suggested for use in patients with hypertension.[6]

That would be interesting to know mayzoo. It looks like transdermal can affect blood levels rather quickly, but I see where you're coming from i.e. blood level interactions would not be the "bind and block absorbtion," scenario.

mayzoo, You may have already found this. I don't know how the time frame would work given that you are using topical. I guess I would allow extra time for absorbtion rate btwn application and minocycline dosing? http://umm.edu/health/medical/altmed/supplement-interaction/possible-interactions-with-magnesium Possible Interactions with: Magnesium Interactions If you are currently being treated with any of the following medications, you should not use magnesium without first talking to your health care provider.

Thank you for the response rowingmom. No matter where you stand on this subject I think almost everyone agrees that we need to be able to retain the right over what is injected into our bodies and our childrens bodies. The interaction btwn strep pyrogens and M. catarrhalis caught my attention recently, so I thought I would share Back tracking for a minute. http://consumer.heal...oll-693832.html Forty-one percent of parents said under-vaccinated children should not be allowed to attend day care In a different article on this same subject a percentage of parents responded that they would like the names of the unimmunized children. I regularly read comments about selfish parents who should be jailed for neglect, looney toons who don't understand science, if your unvaccinated kid makes mine sick, I'll sue you etc. I wonder if they have considered that the same concept could be appied in reverse? Shifts in pathogens or serotype replacement is not a secret. That's why we went from a seven strain vaccine to a 13 strain (however there are at least 90 known) for S. pneumonia, but it doesn't end there. Not all studies showed the same thing (different areas, colonization rates in certain time frames after introduction of the vaccine and other factors). M catarrhalis is something that I've never heard of. If you wiki it, guess what you'll see that we need for control of this pathogen? I haven't spent a lot of time on this so thoughts are always welcome. http://cid.oxfordjournals.org/content/49/1/124.full A change in patterns of nasopharyngeal colonization is occurring in countries where pneumococcal conjugate vaccines are used widely. Colonization by vaccine serotypes of pneumococcus is decreasing, and colonization by the nonvaccine pneumococcal serotypes H. influenzae and M. catarrhalis is increasing, resulting in a shift in the pathogens that cause otitis media [45, 46]. Revai et al. [47] demonstrated a significantly greater prevalence of M. catarrhalis in the nasopharynx during episodes of otitis media in children who had received the vaccine, compared with the prevalence among episodes that occurred before introduction of the pneumococcal conjugate vaccine. Pneumococcal vaccination does not affect the genetic diversity of nasopharyngeal isolates of M. catarrhalis, suggesting that the increase in prevalence of colonization will translate to increased rates of otitis media [48]. Similar shifts are being observed among children and adults with sinusitis [36, 49]. http://www.ncbi.nlm.nih.gov/pubmed/15501804 Moraxella catarrhalis coaggregates with Streptococcus pyogenes and modulates interactions of S. pyogenes with human epithelial cells. The pathogens Streptococcus pyogenes and Moraxella catarrhalis colonize overlapping regions of the human nasopharynx. We have found that M. catarrhalis can dramatically increase S. pyogenes adherence to human epithelial cells and that species-specific coaggregation of these bacteria correlates with this enhanced adherence.

Thank you EA mom. That did give me a chuckle! Sometimes when I post, there is something that's really irritating me. The Jenny McCarthy remarks always give me a BAD reaction (Offit). Even the worst blogs with numerous errors (which I make myself although I try very hard not to do or leave queston marks if unsure...lots of those as I don't want to sound like I have knowledge or expertise that I don't have) I just NEVER ever read "well Jenny McCarthy says." There have been days that I thought my eyeballs were going to start bleeding from reading. I have 13 tabs open on my computer right now and it's hot. There are so many other things that I should be doing, like finishing fastening lighted garland to my kitchen cabinets. I have a few days off and I'm trying to get a jump on Christmas decorating. I know the parents on this forum are not waiting to see what a famous television personality has to say about PANDAS or autoimmunity or TS or Lyme disease. It's just so insulting and out of touch with what's really going on. Last night, I'm on a Pub chair (taller) with this garland and light wires strung around my ankles trying to reach the floral wire and wondering when I was going to fall and end up in ER where undoubtedly I would have to argue about not wanting a tetanus shot. I wondered if I hit my head hard enough if I would be able to recall that the TD still has 25 mcgs of thimerosal and that I was opposed to getting the Tdap because I could still sicken an infant by spreading asymptomatic pertussis, parapertussis or pertactin-free pertussis. Would I pronoun pertactin right? Anyway, the TV is on and over and over the poor soul with that horrible shingles rash is on and that's what has me fuming tonight. That commercial along with the new recommendation for Prev 13 for adults and flu vaccines are on constantly. The "Greater Good," is losing out in my mind, as in a few will be harmed so the majority can benefit. Is that guy on the commercial one of the beneficiaries? Now, I'm really hoping someone can comment on what you think this CDC epidemiologist means here. http://www.webmd.com/children/vaccines/news/20131202/chickenpox-vaccine-not-responsible-for-rise-in-shingles-study-says Chickenpox Vaccine Not Responsible for Rise in Shingles, Study Says (bolding mine) 39 percent increase over 18 years remains unexplained on page 2 this statement Is he saying that someday chickenpox will be wiped out world wide and the won't be a need for anyone to be vaccinated at all? Is he saying that a that current vaccination reco. is going to prevent shingles outbreaks forever? Am I missing something, because I can't see the logic? If you inject VZV into someone, how does that align with his statement. Does he really mean that you will someday be getting a shingles vaccination every 5 years or what? Part two of why this has me fuming. I guess anyone who has an interest can decide who you feel is being more truthful. If you can make it through this whole paper, I think it would be more helpful than the abstract. Threats of legal action to surpress publishing, what might explain a lack of incidence of shingle increasing (surveillance in areas where the "chicken pox shot," was not widely administered/ aged community etc). Now remember, the chickenpox vaccine program was introduced in 1996 per the article and here we are in 2014 with a 39 percent increase and it's unexplained? Goldman quit, fought back and published. I say thank you very much Mr. Goldman. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759842/ G.S. Goldman and P.G. King abstract http://www.ncbi.nlm.nih.gov/pubmed/22659447 Vaccine. 2013 Mar 25;31(13):1680-94. doi: 10.1016/j.vaccine.2012.05.050. Epub 2012 Jun 1. Review of the United States universal varicella vaccination program: Herpes zoster incidence rates, cost-effectiveness, and vaccine efficacy based primarily on the Antelope Valley Varicella Active Surveillance Project data.

Well if Dr. Offit has his way, at least our health care providers will be better able to address our concerns.... http://www.latimes.com/local/california/la-me-pediatricians-vaccines-20141031-story.html#page=1 If you have the stomach after reading that, I would like to know what others think might be happening here and if anyone has heard anything about this? It doesn't seem like it would be difficult to say what percentage of stains in recent out breaks of pertussis were pertactin free. The first few are an overview of what many of the headlines look like and pointing out how they are trying to put pressure on parents with tougher exemptions. The next set are sort of a rebuttal. http://vtdigger.org/2012/12/17/mullin-whooping-cough-numbers-show-vaccine-rates-need-to-be-higher/ Mullin: Whooping cough numbers show vaccine rates need to be higher http://consumer.healthday.com/kids-health-information-23/misc-kid-s-health-news-435/parents-want-kids-in-daycare-to-be-vaccinated-poll-693832.html http://vaccinenewsdaily.com/medical_countermeasures/331497-new-immunization-requirements-take-effect-in-minnesota-next-week/ http://vtdigger.org/2012/10/08/90-percent-of-whooping-cough-cases-in-vermont-among-vaccinated-children/ http://www.theguardian.com/world/2014/apr/15/whooping-cough-vaccine-may-have-lost-its-punch-as-bacterium-evolves and . http://www.ncbi.nlm.nih.gov/pubmed/25301209 Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage. http://www.beyondconformity.co.nz/hilarys-desk/why-the-hurry-ministry-of-health Hilary's Desk Why the hurry, Ministry of Health?

Jan, You're welcome. I hope I'm getting this right! I think that was speculation from the thread I posted? I would have to reread this too. This is more that I copied from some notes that I had saved. The paper talks about clarithromycin (macrolide) as is azith. IL4 was particularly interesting since kids were loaded with seasonal allergies per testing. I think that's what caused me to take notes on this. http://jac.oxfordjournals.org/content/56/3/502.full.pdf Differential effects of three antibiotics on T helper cell cytokine expression Under conclusion from wiki Function IFNγ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFNγ is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. Aberrant IFNγ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNγ is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.[7][8] Function IL4 It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. IL-4 decreases the production of Th1 cells, macrophages, IFN-gamma, and dendritic cell IL-12. Overproduction of IL-4 is associated with allergies.[2] Here are a couple of things on anti inflammatory effects of macrolides. Wonder if there are changes depending on where you are in the course of treatment? http://www.ncbi.nlm.nih.gov/pubmed/15590715 Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? http://www.ncbi.nlm.nih.gov/pubmed/16153572 Macrolides and airway inflammation in children.

Jan, You might want to read through some discussion here http://forums.phoenixrising.me/index.php?threads/my-hypothesis-on-th2-to-th1-immunomodulators-in-cfs.8447/ When an anti biotic switches the action of the immune system (activates an alternate arm) you may be increasing the function of a more inflammatory response at least initially. Probiotics can have this effect too. Just another perspective to consider.