kim

reading thru the site, made me think of something that I read recently. Thanks for posting this Cheri. http://orthomolecular.org/resources/omns/v04n25.shtml High Doses of Vitamins Fight Alzheimer's Disease Why Don't Doctors Recommend Them Now? (OMNS, December 9, 2008) The news media recently reported that "huge doses of an ordinary vitamin appeared to eliminate memory problems in mice with the rodent equivalent of Alzheimer's disease." They then quickly added that "scientists aren't ready to recommend that people try the vitamin on their own outside of normal doses." (1) In other words, extra-large amounts of a vitamin are helpful, so don't you take them! That does not even pass the straight-faced test. So what's the story? Researchers at the University of California at Irvine gave the human dose equivalent of 2,000 to 3,000 mg of vitamin B3 to mice with Alzheimer's. (2) It worked. Kim Green, one of the researchers, is quoted as saying, "Cognitively, they were cured. They performed as if they'd never developed the disease."

Sarah, Happy to hear you're seeing improvements. When I read your post, had to share this link. Great video of hope, a mothers determination and quite a testiment to HBOT. Don't watch if you're feeling emotionally fragile thou. It's heart wretching. http://www.ihausa.org/video/montel.html

Colleen, Wondering how your son is doing and what you decided to do about the anti biotic? I had a little time to read thru the articles that I posted (2nd one anyway) and I was wondering if diluted apple cider vinegar would do anything to keep strep away from itcy pox? Does anyone have any good remedies for that?

I got thinking that scanning that last article, it didn't look like the one I was looking for. I knew there was something about sweat repressing secondary strep. I think this is the one http://whale.to/a/butler_chickenpox.html

Colleen I have so little time today but I typed in Varicella+ Hilary Butler and turned up a page by her. She was such an awesome resource during my vax research. Here's the link http://www.whale.to/m/butler11.html

double post again

Colleen, I don't think that you want your son on anti biotics while he's fighting chicken pox. From memory here, the anti biotic will affect the cells that clean up the dead cells as the varicella die off. Also, you want a low protein diet or as many liquids as possible so the liver can work to detoxify the dying virus (you don't want it busy digesting food). No steroids (if at all possible...don't know what you do with an asmatic child) or Nsaids either. You can probably do a search of why the "no antibiotic during chicken pox" rule, unless there is a secondary bacterial infection for a better explanation than what I gave. Selenium Vit A no or extremely low protein were rec to me, if the boys got CP

if someone only takes away one thing from all of this I hope it's HOPE especially for the individuals/families that are severely affected with neuro disorders. I DO believe progress is being made. http://www.eurekalert.org/pub_releases/200...u-mso120308.php Memory study on mice offers new insights into understanding autism, NYU, Baylor scientists conclude also, this looks like a really good idea to me! http://www.biomedcentral.com/1755-8794/1/58 New Jersey Center for Tourette Syndrome Sharing Repository: methods and sample description

Thanks to Carolyn N, (luv reading your posts Carolyn) I got to looking at glycine again. I had a urine test quite a while back for my youngest son that suggested that he needed glycine. He had high benzoate/low hippurate. I had read in several places that you shouldn't supplement individual amino acids with out a complete AA profile and without physician assistance, which we didn't have at the time. Here are a couple of things that I found. The first one (wiki) makes me wonder once again if this will have a beneficial affect for some but not for others. Are others reading that statement the same way ( glutamate+glycine are excitatory at the glutamate (NMDA) receptors? bolding mine http://en.wikipedia.org/wiki/Glycine As a neurotransmitter Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an Inhibitory postsynaptic potential (IPSP). Strychnine is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. Glycine is a required co-agonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the (NMDA) glutaminergic receptors which are excitatory. The LD50 of glycine is 7930 mg/kg in rats (oral),[10] and it usually causes death by hyperexcitability. As a potential antipsychotic Dr. Daniel Javitt a clinical researcher had studied people who were addicted to PCP (angel dust) and Ketamine (special K) (Javitt, DC, Negative Schizophrenic Symptomatology and the Phencyclydine (PCP) Model of Schizophrenia, Hillside Journal of Psychiatry 1987 9:12-35. Their brains had been damaged by the use of this drug. In studies, it was found that their glutamate receptors had been damaged. Since use of PCP and ketamine creates psychosis similar to schizophrenia, it was hypothesized that giving glycine to people with schizophrenia would potentially reduce their psychotic symptoms. In a controlled study people with schizophrenia who were given glycine had their symptoms reduced in a measurable sense, primarily in the area of negative and cognitive symptoms when used as an adjunct to current antipsychotics. There have been some psychiatrists who have used it out of study as a primary antipsychotic with benefits on positive as well as negative and cognitive symptoms. Glycine's primary drawback is its required use in powdered format. However, as an NMDA receptor modulator, it is part of a class of antipsychotics in study that do not cause tardive dyskinesia or diabetes, the current long term side effects of dopaminergic antipsychotics as well as not creating extra pyramdial side effects (movement disorders), weight gain or sedation. These medications along with other new classes of medications in study may eventually replace the current antipsychotics which, from Thorazine to Abilify, have all been based on the dopamine hypothesis and in depleting the levels of dopamine create tardive dykinesia and other Parkinsonian movement disorders and potentially tardive psychosis which is still in study. Glycine, is part of a promising new class of treatment for schizophrenia that may promote a full recovery without debilitating physical side effects. detailed GABA Glycine article http://www.acnp.org/G4/GN401000008/Default.htm Recently, the expression of a1 and a2 subunits has been shown to be developmentally regulated with a switch from the neonatal a2 subunit (strychnine-insensitive) to the adult a1 form (strychnine-sensitive) at about 2 weeks postnatally in the mouse (8). The timing of this "switch" corresponds with the development of spasticity in the mutant spastic mouse (5), prompting speculation that insufficient expression of the adult isoform may underlie some forms of spasticity. http://micro.magnet.fsu.edu/aminoacids/pages/glycine.html Glycine is the simplest amino acid and is the only amino acid that is not optically active (it has no stereoisomers). This amino acid is essential for the biosynthesis of nucleic acids as well as of bile acids, porphyrins, creatine phosphate, and other amino acids. On a molar basis, glycine is the second most common amino acid found in proteins and enzymes being incorporated at the rate of 7.5 percent compared to the other amino acids. Glycine is also similar to gamma-aminobutyric acid and glutamic acid in the ability to inhibit neurotransmitter signals in the central nervous system. http://www.physorg.com/news144681111.html Medicine & Health / Research The nonessential amino acid glycine has been shown to be anti-inflammatory in several animal injury models. Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplantation. The influence of dietary glycine on oxidant-induced or cholestatic liver injury was not known. http://www.jneurosci.org/cgi/content/abstract/28/39/9755 Thus, our results demonstrate the central role played by GlyT2 in determining inhibitory phenotype and therefore in the physiology and pathology of inhibitory circuits.

Bonnie, Your question from this thread is a good one. Seemed like it needed a thread of it's own http://www.latitudes.org/forums/index.php?showtopic=4206 http://www.itmonline.org/arts/glutamine.htm See what you can make of the above article. The glutamine/glutamate/MSG and how the conversion is made to GABA is a huge topic in itself. The link that I posted is just ONE resource. A search of the forum will probably pull up some good info too. I've struggled with this whole thing myself in the past.

remove double post

Bonnie, From the statements quoted above, I think the more important issue is whether or not you have a mutation which is preventing P13K from working. It certainly makes sense to me that you might want to avoid glutamate stimulating supplements if you had the suspected mutation, however glutamate is converted to GABA which is inhibitory, so these "loops" functioning properly is what's essential. Sorry not to be able to provide anything more helpful.

http://www.ncbi.nlm.nih.gov/pubmed/18928402?dopt=Abstract Akt/GSK3 Signaling in the Action of Psychotropic Drugs and I believe there is a relationship btwn Akt and P13K that was refered to in previous post. I wanted to leave this here, so I could find it again as I'm working on this. Tumor and vessel involvement are pathways that I'm personaly interested in. Also, glycogen systhesis. edit....Need to leave this here too http://www.ncbi.nlm.nih.gov/pubmed/1847373...ogdbfrom=pubmed PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN is a dual protein/lipid phosphatase which main substrate is the phosphatidyl-inositol,3,4,5 triphosphate (PIP3), the product of PI3K.

Did anyone open this link and see Autism listed under adverse events for Tripedia? It's 9th from the bottom. The site that listed this is The Vaccine Healthcare Center’s Network (VHCN), a collaboration of the Department of Defense (DoD) and Center’s for Disease Control (CDC) according to http://www.ageofautism.com/2008/12/dtap-side-effec.html Here is the site http://74.125.77.132/search?q=cache:AwylZV...mp;client=safar above is a link that someone got a hold of that still works. If you click on the new link, this is how the page looks now (under revision) http://www.vhcinfo.org/subpage.asp?page=va...es/vaccine_dtap I'm used to reading this stuff and it still takes me time to figure out what it's saying. Just wondered if anyone else tried. The Dept of defense apparently has some interesting things to say about vaccines. Below link to article by David Kirby http://www.huffingtonpost.com/david-kirby/...f_b_148490.html

Carolyn, Your very welcome. So anxious to hear news of your new arrival! A cruise hau? Good for you, sounds like you have a lot going on right now! Guy, There are many concerns with vaccines other than thimerosal. Again, I'm sure genetic susceptability is playing a part and some my be able to handle vaccines a lot better than other based on many factors. Sorting out possible dangers associated and actual necessity (risk/reward) of a given vaccine has taken up lots of time around here I feel strongly that we are going to see a shift in the current way vaccines are administered. They won't admit wrong doing, they'll cover it up with statements like "while no proof exsists that multiple vaccines cause an increase in adverse events, as a precautionary measure, we are now recommending blah, blah, blah." That's my guess. A statement along these same lines was released in regards to the removal of thimerosal in most vaccines. I think this is a very important article. This is not the first time info has disappeared. Lots of good links and info in comments section too http://www.ageofautism.com/2008/12/dtap-side-effec.html

from same article

New study There have been many headlines lately regarding Golf War syndrome. Looks like a lot of new (previously buried) info is coming out. I don't know if there is any relationship what so ever, but I was wondering why the Dept of defense was behind this study? Also, wondering what substances could alter this pathway. http://www.khou.com/news/local/stories/kho...m.436e64ba.html Rice researchers say they've discovered clue to roots of epilepsy, autism 05:15 PM CST on Monday, December 8, 2008

Pat, A little back on topic here with mito dysfunction . When I said it wasn't really a concern here, I guess that's not completly true. I thought there might be some useful explainations here for people who are waiting for test results. We have recently added carnitine to our supplements. I love the diagram at the bottom of this. Shows the way these things feed into each other. Seems numerous blocks in pathways can result in altered ATP/mito function. Maybe not a full blown genetic alteration, but altered function http://www.metametrix.com/DirectoryOfServi...-BloodUrine.pdf

Ok, it was in the "Mexico" article. It didn't say anti biotic use, it says Pharmaceuticals. http://www.washingtonpost.com/wp-dyn/artic...2-2004Nov9.html U.S. Genetically Modified Corn Is Assailed NAFTA Report Calls Grain a Threat to Mexico; Administration Disputes Study Also, from the immune system study...(My son tested positive to "corn pollen" with reg IgE allergy testing ) http://fanaticcook.blogspot.com/2008/11/mi...ified-corn.html Results

Pat, This is another area that I'm not real up on because I don't think it applies to my boys. They do not have the symptom of low muscle tone or low energy in my estimation. My youngest, who's diet is really yucky due to his limited food choices, has more energy than I can fathom. From the above quote, I'm assuming these are good markers for determining? Regarding the corn thing, I missed the info that you're referring to regarding corn oils. I really didn't get that impression at all, unless it was one of the studies within the article that you read? One of the links referred to corn genetically modified for specific use in anti biotic production. It made it sound like this particular kind was more concerning. I'm going to see if I can find that part.

Pat, I couldn't agree that there is enough speculation about this and that to drive you insane and that honest studies from people outside the realm of criminal prosecution should be conducted in many areas ie vaccines, environmental pollutants, pesticides, GM foods etc. I largely posted that article because of the mito dysfunction and viral info but....if you search genetically modified corn in US, you might be surprised. The FDA decided that we were too stupid to decided for ourselves if we wanted to eat genetically modified crops, so many times you have no idea. The search I mentioned will turn up an article about how Mexico didn't want our genetically modified corn invading their crops (cross breeding in their field) or being sold to them. I didn't save that article, but you might want to read thru these http://fanaticcook.blogspot.com/2008/11/ge...n-found-to.html and near the bottom http://en.wikipedia.org/wiki/Genetically_modified_food http://www.ers.usda.gov/Data/BiotechCrops/

Copy of a post from PANDAS forum.... Reading thru the PANDAS/PITANDS thread, I thought some here might be interested in reading this http://www.huffingtonpost.com/david-kirby/...omment_12213955 The Next Big Autism Bomb: Are 1 in 50 Kids Potentially At Risk? and Another mito article http://www.medscape.com/viewarticle/573004

Reading thru the PANDAS/PITANDS thread, I thought some here might be interested in reading this http://www.huffingtonpost.com/david-kirby/...omment_12213955 The Next Big Autism Bomb: Are 1 in 50 Kids Potentially At Risk? and Another mito article http://www.medscape.com/viewarticle/573004

EAMom, That's funny. I have an unfilled script for steroids here for suspected poison ivy for my oldest son. He had a rash near his mouth. Dr. said probably poison ivy, we'll put him on steroids. I was like "no thanks." She asked why and I told her that he had a tic syndrome and steroids could make it worse. She said "oh, no problem we'll do a steroid burst so it will be over by the time he goes to school on Mon." Well, our tics don't usually go away in a day or three when an episode hits, but whatever. We never did use the script (just a reminder... I don't consider the boys PANDAS). I have listened to poor Michelle go thru this for so long. I took my youngest to a walk in clinic on a weekend for suspected strep. It was. I asked Dr. if he had a problem with zith and he said fine.

Jody, I don't know what type of Dr. you're seeing next week, but if it's a mainstream Dr. you will probably not get them to order some of the tests mentioned on this thread (Oat etc). Here are some things that I did get a mainstream Dr. to order. thyroid lead Vit D level zinc/copper (if they give you flack mention Wilsons disease in relationship to movement disorders). folate B12 celiac marker, which may not give a complete picture, but doesn't hurt to get The type of yeast test that reg ped did for us showed more of an allergic reaction to yeast, not necessarily yeast overgrowth in the gut. Some have reported a positive on this test which is a good thing to know. Some vaccines warn against use, when there is a known yeast allergy. Be sure to request copies of all blood work/tests for your own file and scrutinizing . Even if something falls in the "normal" range, there may be some clues that reg. Dr.s don't pay any attention to. Calcium and magnesium levels can be ordered, but they won't tell you much about how well the body/cells are utilizing it unless you do a test like spectracell, which I think someone already mentioned. There seems to be a little something "off" with my boys platelets. Comparing blood work from both boys (last time which was over two years ago) we are in the normal range now, but low. Also, Dr recently ordered CBC morphology. My son showed anisocytosis 1+, Macrocytosis 1+ and ovalocytes 2+. His Dr. acted like this wasn't completly normal, but didn't know if it had any real significance. I know it has to do with the shape of the cells, but I'm not sure at this point if it means much either (other than ovalocytes seem to suggest a resistance to malaria... ohhh goody what a clue!!!!) We have a history of high MPV and platelets on the low side. Good luck and please let us know how it goes