rowingmom

http://cid.oxfordjournals.org/content/41/11/1559.long Invasive Saccharomyces Infection: A Comprehensive Review" S. boulardii accounted for 51.3% of fungemias and was exclusively isolated from blood. Compared with patients infected with S. cerevisiae, patients infected with S. boulardii were more frequently immunocompetent and had a better prognosis. Saccharomyces invasive infection was clinically indistinguishable from an invasive candidiasis. Overall, S. cerevisiae clinical isolates exhibited low susceptibility to amphotericin B and azole derivatives. However, global outcome was favorable in 62% of the cases. Treatment with intravenous amphotericin B and fluconazole, in combination with central vascular catheter removal, were effective therapeutic options. Conclusion. Saccharomyces organisms should now be added to the growing list of emerging fungal pathogens. Special caution should be taken regarding the use of S. boulardii probiotic preparations ". For these reasons we don't use it.

Did you see this about Seneff? http://www.alternet.org/food/meet-controversial-mit-scientist-who-claims-have-discovered-cause-gluten-sensitivty?paging=off&current_page=1#bookmark "I’m a computer scientist. I do natural language processing. I’ve done that for many years, we’ve built dialog systems that allow people to interact with information on the web through natural language, and I’ve transitioned to applications in biology over the past six or seven years." "Recently what I’ve gotten really interested in is processing the literature. So if you take the research literature on some topic, for example glyphosate, you can let the computer use NLP [Natural Language Processing] to help you organize the information that’s in the articles, and help you figure out the story. I think it’s a very powerful method for helping a biologist understand the biology, biochemistry and medical literature, and interpret it."

Both of DD's exacerbations were associated with live attenuated vaccination (MMR), but not with flumist. Our family has never used that specific vaccine. Dd's intial gradual loss of speech and fine motor ability happened shortly after a significant fever produced by her 15 month MMR vaccination. Her second exacerbation and the beginning of her PANS symptoms at 7 years of age, began approx. 1 month after the MMR booster. During this time, however, she also had an unidentified bug bite with non-EM rash.

Here is the Free Full test pdf: http://www.mdpi.com/1099-4300/15/1/372

Thank you so much. He certainly has a different way of looking at things.

I'm glad your child doesn't react, but several children here have had problems with attenuated vaccines. I thought the association of live vaccine with strep colonization might be of interest to some parents. It's best to make informed decisions, and this information is not being widely circulated.

I thought of your daughter when I read this article. It links c-diff with depression and the drugs used to treat depression with c-diff. http://renegadehealth.com/blog/2014/02/28/your-brain-on-bugs-will-bacteria-be-the-next-treatment-for-anxiety-and-depression "We know that Clostridium difficile, the nasty gut hospital-based gut infection that kills 14,000 people each year in the U.S., is associated with depression and dementia. Two antidepressants, mirtazapine (Remeron) and fluoxetine (Prozac), are linked to a nearly a 50 percent increased risk for Clostridium difficile infection." I'm not sure where they found this information (there are not references listed), but it might be worth googling before you begin antidepressants.

Live attenuated influenza vaccine ehances colonization of strep. pneumoniae and staph aureus in mice. http://mbio.asm.org/content/5/1/e01040-13.long http://www.greenmedinfo.com/blog/live-flu-vaccines-increase-infectious-bacteria-counts-100-fold-mice The main implication of this study is that, "live attenuated viral vaccines may have unintended consequences on important human bacterial pathogens unrelated to the vaccine target species."

We are using knotweed 3x daily and meriva 2x daily (morning and evening).

Curcumin is not absorbed very well, so a liposomal brand would be good. Longvida ($$$) or meriva (Source Naturals, Thorne). This worked well to get DD out of the ticcing mess caused by GSE. I think the autism boards suggest liposomal forms as well (Enhansa).

If you are going natural why don't you try Japanese knotweed or kudzu as an antiinflammatory. DD does really well with 1/4 - 1/2 tsp Japanese knotweed 3x daily. You can use tincture or organic dried herb. WoodLandEssence carries the tinctures, 1stChineseHerbs the powdered herb. DD has been on this dose for 1.5 years now and has had no liver enzyme problems.

Could you share your protocol please? I'm not sure we are dealing with external mold toxins, but definately internal yeast.

I too was going to suggest removing additional supps and try to get back to the baseline. If you add anything, wait a week or so before adding something else and you will be better able to tease out response to individual supps. Have you tested for c diff / yeast or other bowel microbes? Artemesinin and wormwood can cause parasite/protozoan/yeast die-off. We also had a HUGE flare caused by grapefruitseed extract, and I mean back to square one. The best thing is that through experimentation (of which I am a great proponent) and careful note-keeping you have discovered your wonderful child is still in there. You can find her again. You are a Great Mom! Keep at it.

You may be a trigger, but so are other infectious people your children come in contact with. The real problem is not your infection (if your body is handling it properly and you are asymptomatic), but your children's overactive response to infectious triggers in general. If both you and your children have autoimmune problems it could be a combination of genetic susceptability and various environmental insults (pesticides, heavy metals (esp in vaccinations), EMFs) on all of your immune systems.

Thanks! Here's another article from WAPF found following the Comments links from AgeofAutism: http://www.westonaprice.org/environmental-toxins/pesticides-and-polio And a new one from AoA today: http://www.ageofautism.com/2014/02/doctors-may-have-missed-pesticide-clue-in-californias-polio-like-cluster.html

Ours was new onset and started shortly after DD developed ticcing and the other symptoms I associate with PANS (Aug 2008 - see my signature). Prior to that she had been dry at night. Night-time wetting was sporatic and would get worse with strep or other infections (as all the PANS symptoms did), as did urinary frequency (she was tested for UTI so many times). I didn't realize either was a symptom until I twigged on PANS/PANDAS in 2011. For her this symptom resolved quickly with bartonella abx treatment and only flared once (again with all other PANS symptoms) when I tried to add GSE (grapefruitseed extract) to her protocol. The LLMD and I have never quite figured out what caused that flare. It could have been a yeast die-off, or a buildup of toxins caused by a CYP450 blockage (grapefruit does that and is the reason why you shouldn't drink grapefruit juice while taking statins).

Night-time urine leakage was a cue for us.

Have you considered that EMFs might be part of your problem? I'm sure there were wireless emissions all over NYU and planes are a bad offender as well. DD and I are quite electro-sensitive, and it was worse when we were sick. Before we started treatment I could tell when someone in the house had turned on the computer wireless - I would get shaky, have palpitations and couldn't think straight. I would go and check, and it would be on. We keep the wireless off (and disabled) at all times now unless we are downloading something to a portable device. Now I'm not so bad. DD still reacts with increased ticcing and pain when we are in an area with high wireless emissions, ie., the mall or a museum. She also becomes strangely fatigued in these places. When she is outdoors she can walk or cycle for miles. I always turn off the electric circuits to our bedrooms at night, and we have both been sleeping better. Usually my son turns off the circuits before he goes to bed. If he forgets, both DD and I will wake around 3 am, I will then go and check the breaker, and voila - it's on. Your body can only take so much stress and EMFs can be a stressor on your body's own electrical systems (brain, heart, nervous system).

@ 3bmom - There are two schools of thought on supplementation. 1) If the parasites (bacteria) require a nutrient does supplementing simply go straight to the infection and strengthen it; 2) or does supplementation allow your body access to nutrients that would otherwise be lost to parasitism and aid in healing. This would ultimately restore function lost to deficiency. Many LLMD's suggest reducing nutrient intake in a bid to weaken bacteria. Ours however, said to supplement, especially magnesium. And so does Buhner. He says that parasite's will keep depleating nutrients until you are no longer functional (or worse). They don't care if you are healthy, or sick and weakened by deficiency, they will continue to take until you grow cold. The point is to bring the immune system (I'm seriously thinking gut here) back to a point where your body can live in equilibrium with the parasites. You can't kill them all, so you might as well feed them, and yourself, and keep everyone happy. DD doesn't take glucosamine because she doesn't have joint involvement, however I have been for a while and have noticed reduced joint pain (non-existant), however my joints have taken up cracking like crazy, especially my knees when I squat. So I'm not sure if it's actually helping, sounds funny though. Supplementing magnesium has helped both of us and significantly decreased my heart palpitations. DD does wonderfully with epsom salt baths (magnesium sulfate) to increase both magnesium and sulfate, however if you have a CBS mutation you might have problems with it. It wouldn't hurt to try and see what happens (I love experimenting on myself (n=1) - it's the only way to learn). And I'm not scared to do it (go low and slow), because there is no doctor out there who is going to tell me for sure what works for me. If it doesn't work, it doesn't work. DD had a bad allergic reaction to bactrim (sulpha drug) but is fine with sulfate and other sulphers (garlic, cruciferous vegetables). Some people can't handle any of it.

The parents will be the first to figure it out.

The trouble with the first point is that often blood counts are not significantly out of the normal range, or at least not enough to raise a red flag with most doctors. Throughout treatment DD's lymph's were always a little low, but not much. Only at one time did her CBC indicate very low a WBC count (her sample was taken while she had the flu) and the LLMD called us in a panic, saying to stop all abx, thinking it was a drug reaction. It wasn't, it was the flu and all parameters returned to normal after she recovered. A very low CD57 has been our only indication that NK cells are being impacted, and most doctors don't test for that. I have gotten to the point in this ordeal that I believe I can do a better job at treating DD with herbs and other more natural treatments than I can with continued abx. Our LLMD knows little about herbs, and so after reading through Buhner's books at least once (a few more times would be good), consulting with his associate, and bringing aboard a ND versed in Traditional Chinese Medicine, I am comfortable with my decision to forgo conventional medical treatment. We continue with regular CBC/CMP testing through the LLMD. DD continues to heal, improving by adding herbs that Buhner suggests for viral/protozoan infections. We have never tested for viral infections and tested negative for babesia (a protozoa), but I have found another answer to our puzzle. When you run out of tests, or money or which ever comes first, you realize that you can only count on yourself and your ability/willingness to investigate alternative options. Some work - start slow, record every reaction - you may find a way out. There are so many potential explainations for the impacted immune systems of our children: High level EMFs disrupt our bodies electrical systems causing added stress. Pesticides destroy the gut symbionts responsible for much of our immune system. Vaccinations, well don't get me started on the potential causes for harm. It's not just infections causing our kids problems and it's not just abx/antivirals that are going to fix them. We have too look outside the allopathic box too.

From the above mentioned paper: Table 2. Illustration of the myriad ways in which glyphosate can be linked to celiac disease or its associated pathologies. Disruption of gut bacteria Gfect Dysfunction Consequences reduced Bifidobacteria - impaired gluten breakdown – transglutaminase antibodies reduced Lactobacillus - impaired phytase breakdown reduced selenoproteins metal chelation autoimmune thyroid disease anaerobic E. coli - indole toxicity - kidney failure C. diff overgrowth - p-Cresol toxicity - kidney failure Desulfovibrio overgrowth - hydrogen sulfide gas - nflammation Transition metal chelation Glyphosate Effect Dysfunction Consequences cobalt deficiency cobalamin deficiency reduced methionine elevated homocysteine neurodegenerative diseases impaired protein synthesis heart disease molybdenum deficiency inhibited sulfite oxidase inhibited xanthine oxidase impaired sulfate supply DNA damage/cancer teratogenesis megaloblastic anemia iron deficiency anemia CYP enzyme inhibition Glyphosate Impairment Dysfunction Consequences vitamin D3 inactivation impaired calcium metabolism osteoporosis; cancer risk retinoic acid catabolism suppressed transglutaminase teratogenesis bile acid synthesis impaired fat metabolism impaired sulfate supply gall bladder disease pancreatitis xenobiotic detoxification increased toxin sensitivity impaired indole breakdown liver disease macrocytic anemia kidney failure nitrate reductase venous constriction venous thrombosis Shikimate pathway suppression Glyphosate Effect Dysfunction Consequences tryptophan deficiency impaired serotonin supply hypersensitive receptors depression nausea, diarrhea

Perhaps gluten intolerance is not to blame for bowel inflammation, but the high doses of Roundup used on wheat. Another Samsel/Seneff paper: Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance http://nhrighttoknowgmo.org/BreakingNews/Glyphosate_II_Samsel-Seneff.pdf Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate’s strong ability to chelate these elements. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate’s known depletion of these amino acids. Celiac disease patients have an increased risk to non-Hodgkin’s lymphoma, which has also been implicated in glyphosate exposure.

You guys are amazing!

DD would generally flare 1-2 days before an illness (cold, strep infection, stomach virus), with the worst part of the flare being during the illness. If a fever was involved the symptoms would resolve during the fever but return after the fever had broken. In both cases the flare would then continue for several days afterwards. DD is at a point now where she no longer flares with illness. The last one she had happened approx. 1 week before she developed a yeast infection, so her body was dealing with increasing yeast. This latest flare included only red circles under the eyes and some ticcing (and well, itching). All other symptoms (urinary frequency, loss of handwriting/math ability, emotional lability, distractability, insomnia, etc.) remained at baseline (which now is 0).