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New Pubmed Article TS/rx


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Carole,

I couldn't get it to open. Can you copy and paste it? What kind of stimulation are they suggesting? Craniosacrial? Have others here tried this kind of treatments? Thanks for posting!

Michele

Hello,

New Pubmed enews article in my mail today 7/31...out of France

Basal ganglia stimulation for TS

http://www.medscape.com/viewarticle/578240...1&src=nldne

 

Mustang Carole

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Oops sorry...try this copied one>>>>>>

 

 

Basal Ganglia Stimulation Reduces Tic Severity in Tourette Syndrome

 

 

 

NEW YORK (Reuters Health) Jul 29 - Basal ganglia stimulation may offer substantial improvement for some patients with Tourette syndrome, according to a report in the July issue of the Archives of Neurology.

 

Previous attempts at stimulation of the thalamus and internal part of the globus pallidus have yielded variable effects on tics, the authors explain.

 

Dr. Marie-Laure Welter from Hopital de la Salpetriere, Paris, France and colleagues evaluated the efficacy of high-frequency stimulation of two associative-limbic relays (the centromedian-parafascicular complex of the thalamus and the ventromedial part of the internal globus pallidus) in three patients with severe, medically refractory Tourette syndrome.

 

All three patients experienced a marked improvement in tic severity within hours to days after the operation, the authors report. The best improvement in tic severity was obtained with ventromedial internal globus pallidus stimulation.

 

With stimulation, one patient was able to discontinue dopamine antagonist medication and another was able to reduce the dosage of such medication by 66%.

 

Stimulation also dramatically reduced self-injurious behaviors in one patient and resolved the moderate generalized anxiety disorder in another patient, the report indicates. Neuropsychological status remained stable in all patients.

 

The effects of stimulation were sustained or increased during the 2-month study period in two patients, the investigators say, but the improvement decreased or disappeared after 2 months in the third patient.

 

"This study suggests that high-frequency stimulation of the ventromedial part of the internal globus pallidus can produce a marked reduction in tic severity in patients with Tourette syndrome," the authors conclude, "which is in the process of being tested in a large patient population."

 

Arch Neurol 2008;65:952-957.

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