CAN SOMEONE ANSWER ME?

[MamaOnAMission]

Do all of these drugs work on yeast and fungals in the same way?

[Mayzoo]

Amphotericin:

 

Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components.

 

Nystatin:

 

Nystatin is an antimycotic polyene antibiotic obtained from Streptomyces noursei. Its structural formula. Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast–like fungi. Candida albicans demonstrates no significant resistance to nystatin in vitro on repeated subculture in increasing levels of nystatin; other Candida species become quite resistant. Generally, resistance does not develop in vivo. Nystatin acts by binding to sterols in the cell membrane of susceptible Candida species with a resultant change in membrane permeability allowing leakage of intracellular components. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.

 

Diflucan:

 

Fluconazole is a highly selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. This enzyme functions to convert lanosterol to ergosterol. The subsequent loss of normal sterols correlates with the accumulation of 14-α-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.

 

 

All similar, but slightly different. If you have a more specific condition or question, maybe I can answer more clearly.

 

 

http://www.drugs.com/

Edited July 28, 2012 by Mayzoo

[hugs2day]

Nystation treats fungal infections in the gut not systemic. Diflucan treats yeast systemically and can be hard on the liver. Amphoceritin used when the yeast infections is determined to be resistant to Diflucan. Amphoceritin tastes like paint chips.

 

Diflucan is usually the best place to start when your child has severe behaviors. The unexplained laughing, giddiness, etc.

[philamom]

How long can you be on diflucan before possible liver problems?

[NancyD]

My DD was on Diflucan for years without any problem and then when we started treating for Lyme and Bartonella her liver function stayed elevated no matter what we tried. We switched to Amphotericin B two years ago and liver has been normal ever since.

 

How long can you be on diflucan before possible liver problems?

[Kimflow]

"Nystatin is an antimycotic polyene antibiotic obtained from Streptomyces noursei"

 

I have asked this question before: if some probiotics with strep. species in them can cause problems, how come no one is concerned that nystatin obtained from streptomyces. I guess not significant??????

[philamom]

How would one differentiate between systemic yeast and a fungal (yeast) infection in the gut?

[mdmom]

Some docs hit yeast with multiple antifungals, I guess to attack it in the gut and systemically. My entire family takes Nystatin (for gut) Diflucan (systemic) and Mycelex (upper GI/mouth). We are no longer yeasty because of this protocol (15 months now). We take Milk Thistle, NAC and antioxidant supplements to protect liver. Haven't had liver issues yet.

[philamom]

My daughter's recent stool sample from Quest came back with Saccharomyces cerevisiae. Does anyone know what this is? Is it a type of Albicans Candida?

 

just googled- possibly from the Florastor?

Edited July 30, 2012 by philamom

[philamom]

I'm still confused on how you know whether yeast is systemic or in the gut, or both. If it shows up in a stool sample you know it's in the gut, but what are the symptoms of systemic yeast? How do you diagnose systemic yeast - a blood test? Or by symptoms?

 

I was given three different answers from three different doctors on how to treat the yeast (saccharomyces cerevisiae) result from my daughter's recent stool sample. One said not to treat since it is most likely from the florastor probiotic. Another suggested 10 days of diflucan, and another a month of Nystatin. thx

 

edit- I decided to go with the Nystatin. I gave Nystatin a while back but after taking one pill my daughter was crying excessively, so I stopped it. Hopefully, a different reaction this time. Can someone remind me if it's ok to give at same time as probiotics? thx again

Edited August 1, 2012 by philamom

[mdmom]

It's not okay to give probiotics with antifungals. Most probiotics contain beneficial bacteria and fungus, so you would be killing off the good fungus. Saccharomyces Boulardi is the one probiotic you can take with an antibiotic since it is a beneficial yeast (fungus), but obviously you would want to avoid an antifungal with this one.

[philamom]

It's not okay to give probiotics with antifungals. Most probiotics contain beneficial bacteria and fungus, so you would be killing off the good fungus. Saccharomyces Boulardi is the one probiotic you can take with an antibiotic since it is a beneficial yeast (fungus), but obviously you would want to avoid an antifungal with this one.

So you need to space probiotics away from Nystatin, even the ones besides Sacc. Boulardi? How far apart? Can u give Nystatin with antibiotics?

Edited August 1, 2012 by philamom

[Wombat140]

But that makes no sense. Surely the point of taking probiotics is to replace some of the good bacteria/fungi that are being killed off? Even if the antibiotics destroy some of the probiotic bacteria, surely some will get through and that must be better than nothing. I know all the things I've read suggest taking probiotics if you're on long-term antibiotics.

[mdmom]

Nystatin with ABX is OK. I think the rule is space antibiotics and antifungals at least 2 hours apart from probiotics. We do probiotics at lunch, and abx and antifungals at breakfast, dinner, bedtime. Some suggest probiotics at night, so they can sit in the gut alone and work their magic. We just happen to take abx/antifungals at bedtime in case of stomach upset (our docs recommendation).