UC Davis Study/autism/mito

[kim]

http://www.eurekalert.org/pub_releases/2010-11/uoc--uds112410.php

 

Public release date: 30-Nov-2010

 

UC Davis study finds children with autism have mitochondrial dysfunction

 

(CHICAGO) -- Children with autism are far more likely to have deficits in their ability to produce cellular energy than are typically developing children, a new study by researchers at UC Davis has found. The study, published today in the Journal of the American Medical Association (JAMA), found that cumulative damage and oxidative stress in mitochondria, the cell's energy producer, could influence both the onset and severity of autism, suggesting a strong link between autism and mitochondrial defects.

 

 

http://www.ageofautism.com/2010/09/government-awards-hannah-poling-15-million-in-vaccine-injury-case.html?cid=6a00d8357f3f2969e20134872f7a19970c

 

September 09, 2010

Government Awards Hannah Poling $1.5 Million in Vaccine Injury Case

 

The government lawyers mumbled something Orwellian and incoherent about a pre-existing mitochondrial disorder and how vaccines didn't cause Hannah's autism -- the condition just "resulted" from the vaccines. Translation: The medical industry's wall of doublespeak, delay and denial is crumbling and today, at least, one child got justice. More, many more, to come.

 

 

So maybe Hannah's case wasn't as RARE RARE RARE as the story was spun? For anyone who is of the opinion that the pressure placed on parents to vaccinate fully, on schedule, is a dangerous propostition for some children, please share this with your health care professionals.

 

I found the mention of high levels of pyruvate in the first article interesting. I think we have had at least one parent report a high pyruvate level found in their child. Also, pyruvate kinase has been suspected as an auto antigen in TS/OCD and related disorders. I didn't know the function of pyruvate in the body, so the mention caught my attention. The UC article talks of an inability to process it fast enough, the TS study identifies it as an auto antigen, so not spreaking of the same problem, wouldn' think.

 

Identification of Pyruvate Kinase as an Antigen Associated with Tourette Syndrome

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853370/

[trggirl]

Kim, thank you for posting this!! How do you test for pyruvate kinase levels or pyruvate kinase antibodies?

[PatAnne]

My son also has been diagnosed with "mitochondrial ASD" by a prominent metabolic geneticist. We tried from age six to get this diagnosed due to his exercise fatigue, heat intolerance, and decompensations during illness. PANDAS was also a significant problem since age 3. The key for us was getting labs like carnitine profiles, serum and urine organic acids, and CPK done when he was ill with a virus. That is were the dysfunction became obvious. Carnitine, Co10, antioxidant supplemetation has really helped him.

 

There are many Hannah's out there, and what I find very interesting is how many of them also suffer from PANDAS.

 

PatAnne

[GraceUnderPressure]

I know that acetyl carnitine is one of the main supps for mitochondrial support. Are CoQ10 & antioxidants directly supportive of mitochondria? Are there any other supps that are directly supportive?

 

And I have some vague memory that has me thinking - aren't pyruvate issues associated with B-6 deficiencies?

Edited December 11, 2010 by GraceUnderPressure

[kim]

Trg Girl,

 

I think pyruvate levels can be checked with a blood test, the auto reactive part looks like it would have to be checked with neuronal tissue, much as Cunningham is doing.

 

GraceUP, In addition to the info already provided by others, if you google mito cocktail or mito support you can get a lot of info on supplements.

 

What is so upsetting about the UC Davis study is the fact that the Poling case is not new.

 

Time Magazine summed up the relevance of the Poling case in 2008: ...(T)here's no denying that the court's decision to award damages to the Poling family puts a chink -- a question mark -- in what had been an unqualified defense of vaccine safety with regard to autism. If Hannah Poling had an underlying condition that made her vulnerable to being harmed by vaccines, it stands to reason that other children might also have such vulnerabilities."

 

I remember watching the comments on Fox from the attorney's, the day this judgement was awarded. It was pathetic/guarded. I wondered (along with thousands of other parents) how long it would take and how many other children would be damaged/suffer until someone said hey...maybe we better take a real look at this. Now we have a small but significant study. Has anyone heard this anywhere but here (I rarely turn the TV on anymore)?

 

I wondered if Hannah's parents wouldn't have been who they were, if this would have ever made it as far as it did. I wondered why this didn't gain momentum even amongst health care workers. If you were a Ped, BY NOW WOULDN'T YOU BE WANTING SOME ANSWERS before you kept shooting infants up with multiple vaccines and having the insurance companies breathing down your neck, if you don't keep your "fully immunized," levels up. Look at this statement and then tell me who we are supposed to rely on, to use common sense and look out for our kids.

 

underlining mine

http://www.cbsnews.com/8301-31727_162-20015982-10391695.html

Then-director of the Centers for Disease Control Julie Gerberding (who is now President of Merck Vaccines) stated: "The government has made absolutely no statement indicating that vaccines are a cause of autism. This does not represent anything other than a very specific situation and a very sad situation as far as the family of the affected child."

 

This isn't going to happen by itself. Gerberding makes her statement and what? Did the government immediately start a follow up study to see if it really was an isolated "specific situation."

 

It's up to everyone of us to be informed, ask the tough questions and expect informed answers from our Dr.s. It's up to us to share info with friends and family. WE have the responsibility as a nation to not let our children fall victim to big business (or have some hard science to base a decision regarding whether or not a particular vaccine IS in the best interest of our child).

 

Sometimes a rant just has to be unleashed for PatAnne's child and every other out there where this finding may prove significant.

Edited December 11, 2010 by kim

[tpotter]

WOW! I treat 2 children who I have seen, personally, go off the deep end following flu vaccination (I was at a quarterly meeting the other day, and another therapist commented: "do you remember what he was like after the Flu vaccine?" So, others were seeing it, too. I was busy handing out websites for everyone to see what PANDAS/PITANDS is all about.

 

Then, 2 weeks ago, a mom of another child on my caseload called to tell me she wouldn't be in that day, because she was having the flu vaccine. I was VERY concrerned, because this child is actually diagosed with PANDAS-like symptoms (that's what her pediatrician came up with, but at least she got abx. I have to be very careful about what I suggest to parents, A few days later, the entire family ended up in the ER with upper respiratory symptoms, and the one child was hospitalized for several days.

 

When Mom called me, I suggested that she start keeping track of increased symptoms and anything that has just happened: vaccines, illness, etc. At that point, I told her about my own children who had become extremely ill from the flu vaccine, and several others, and that we had been told by our docs not to do any more vaccines (granted, my kids have already had their "basic" vaccines...they're older...so the damage is done...one is on the spectrum.) I told her that others have had trouble with the flu vaccine, too, and suggested that she read up on several things, including checking out this website to make her own decisions, and to have a better idea of what to talk to her doc about.

 

This is so frustrating. I keep having this same discussion with my DH...he keeps insisting that the vaccines don't cause it. I'll give him this article.

 

 

[

[kim]

tpotter,

 

Thank you for your response. It's always good to know that the adverse effects on my blood pressure and CNS when I go near this topic are heard and considered even by one person. It's not important that anyone agrees with all of my concerns, only that they investigate for themselves. I hope that the suspected adverse events in those that you know were reported.

 

I'm not not picking on your husband here by any means, but I'd luv you to ask him if the recent news that the vaccines for the rotavirus were contaminated with DNA from known pig viruses, was concerning to him. When it was discovered in the first, they recommended suspension of use and said to use another manufacturers vaccine. When it was discovered in that one too, along with particles from a 2nd virus , they said "oh well, use either one," it's probably not dangerous anyway. Would he still want his infant vaccinated with either of these vaccines when, in the vast majority of severe cases, infection only requires an IV for rehydration? There are many many issues surrounding the use of vaccines other than the "it" controversy.

 

http://articles.cnn.com/2010-03-22/health/rotavirus.vaccine_1_rotavirus-vaccine-rotarix-glaxosmithkline?_s=PM:HEALTH

Rotarix rotavirus vaccine contaminated, officials say

 

http://blogs.wsj.com/health/2010/05/06/now-theres-pig-virus-dna-in-mercks-rotavirus-vaccine-too/

Now There’s Pig Virus DNA in Merck’s Rotavirus Vaccine, Too.

[tpotter]

I agree. And, we are constantly disagreeing on this subject. I think he likes to try to make life "easy" by just believing what he is told, but after everything he keeps seeing with our own kids, it surprises me that he is still sticking to his stand on "vaccines don't cause autism" (although I think he does believe that our kids certainly had a reaction to them...my DS 17 actually broke out in hives from the MMR vaccine when he was 18 months!)

 

Most recently, I mentioned to him about my feelings that vaccines are definitely contributing to autism, and many of the symptoms I'm seeing in my practice, and used one example where a child was bouncing off the walls. He said he had just attended an Autism workshop at work,and someone from the Autism evaluation/tx center at a local (well respected) facility in the area was speaking. Apparently, she refuted that vaccines can cause or contribute to it. I blurted out: "That's XX!" The discussion ended

[PatAnne]

For those interested, Mitoaction.org has excellent articles and screening for mito/ASD. Tomorrow at 12:30 EST there is a call-in with Richard Haas MD, a neuro from UC Davis will discuss mitochondrial dysfuntion in ASD (and his new article). He feels that in some kids the mito is primary, causing the ASD symptoms. In another cohort it's secondary to the ASD.

 

We recently participated in a research study which found low/normal complex I activity in my son, which means he has a deficit in mito functioning for sure, but not a life threatening progressive mitochondrial disease.He absolutely needs the cocktail because he has a functional disorder. He is also immune def, but this often goes along with the big picture as well.

 

Just an FYI, some of the best and brightest out there do admit to seeing clear cut mito/ASD caused by vaccination response. Especially those that endured long lasting fever afterward. In my son's case it was three weeks of fever following 3 triple vaccines in one day. That was enough to cause CNS damage per our geneticist.

 

PatAnne

[Stephanie2]

My boys also have mitochondrial dysfunction (learned after the fact, of course). If only we could get the peds to screen these kids - LOL! Back to reality...

 

Treating them with the mito cocktail has made a very big difference for them. For example, more muscle tone, stamina, ability to function during colds, etc. For one of my boys he even developed more speech.

 

 

I know that acetyl carnitine is one of the main supps for mitochondrial support. Are CoQ10 & antioxidants directly supportive of mitochondria? Are there any other supps that are directly supportive?

 

And I have some vague memory that has me thinking - aren't pyruvate issues associated with B-6 deficiencies?

 

We use:

Carnitine

CoQ10

Vit E

B12 (supposed to use all b vitamins but it tastes terrible so they are not compliant)

I have heard that D-ribose (I think) is very good, but I do not use it. Also, MCT oil used as needed is good.

 

Oh, and regarding the decompensation after vaccines, yes I watched this happen many times, often putting them into a pandas exacerbation as well. They no longer fall apart with illnesses (even had influenza A recently). We no longer do vaccines, just immune support...

 

Now I'm wondering if mito dys should be part of the initial pandas work-up. Is this why my boys are doing so well in terms of pandas, b/c we are supporting the mitochondria, and combating oxidative stress, etc?

Edited December 13, 2010 by Stephanie2