kim

Buster, I'm wondering now if the carbohydrate composition of the protein was not part of this study? As you pointed out on one of the threads, cost constraints or just not part of what they were interested in proving/confirming? Thinking about that remark, I went back and read the psoriasis study that posted somewhere here already. They know the antibodies recognized two proteins, but further study was needed to determine that the antibodies were directed toward GlcNAC. bolding mine http://pt.wkhealth.com/pt/re/clei/abstract...#33;8091!-1 What I keep wondering about, is the brief discussion that we had about NAG (the supplement) showing protection againt autoimmune attack. This sentence in the psoriasis /P. ovale study, is something I'm trying to understand. Since I don't understand how these tests work, I'm wondering if you have any thoughts on the significance of this?

thanks for that Buster. I'm seeing where it looks like the peptidoglycan in the cell wall was not what was found to be cross reactive. I just saw where Nancy posted the a link for the study. Looks like the strep antigen was group A b-hemolytic streptococcus matrix (M) protein? Since Cunningham was the one who found reactivity to GlcNac, I wish they'd toss her that poor little mouse! I do hope this study provides some of the answers that are so badly needed.

Tami, In addition to above, wouldn't it be wonderful if they could develope an immunization that would protect people with a predisposition (i'm not going to say genetic, because it may not be strictly genetic, it may be exposure to something that is causing the abnormal immune response too) ? If a vaccine could be developed that safely created immunity without the "self" attack, well it might be one vaccine that I would be willing to take! That's not how immunizations work though. They are costly to create. Once one is developed, the more people immunized the bigger the profit. Do you think I would expect every child out there to be immunized against strep with a vaccine that is supposedly safe in a PANDAS situation so that my kids and myself would be protected? NO. Just because the design was safer for us than the natural illness, I wouldn't expect it to be safe for everyone. Also, how do we know what might step in and replace strep A if we tinker with another bacteria? Just some random thoughts here. There have been big problems with attempts to make a vaccine for this in the past. This research may help them overcome some of those obsticles. Can't help but to wonder if that plays into the research? I may be just a tad cynical when it comes to vaccines tho

lurker, In this case they were immunizing trying to create the autoimmune response. They immunized with the component of strep suspected of causing the antibody formation that would attack brain tissue in predisposed animals. That is where the mouse model comes in. Read this, maybe it will help you understand why I'm wondering about the mouse and may help you see how some of these mouse models work. Probably better than listening to me ramble trying to get it "just right" which I'm not capable of anyway As always, this is just my best guess. Read this article on a mouse that was engineered to study Sjogren's. http://www.innovations-report.com/html/rep...port-35072.html By knocking out a single gene in mice, immunologists at Duke University Medical Center have mimicked a little-understood autoimmune disorder in humans. In the puzzling disorder, called Sjögren’s syndrome, the person’s tear and salivary glands are affected, causing dry eyes and mouth, as they are damaged by an attack of the person’s own immune cells.

Maybe a mouse that is known to be prone to an autoimmune response that was immunized with GlcNAc? They call it an autoimmune mouse model.

My guess is that they created or obtained a mouse that would have an abnormal recognition of a component of the strep which would then recognize brain tissue in normal mice. bolding mine Using a mouse model of PANDAS, Mady Hornig, MD, associate professor of epidemiology at Columbia University Mailman School of Public Health, and colleagues demonstrate this suspected link between GABHS antibodies and the psychiatric symptoms of the disorder. Immunizing mice with an inactivated form of the bacteria, CII researchers found that the mice exhibited repetitive behaviors reminiscent of children with PANDAS. Injection of antibodies from the immunized mice into the bloodstream of non-immunized mice replicated these behaviors. edit opps...not normal mice, just non immunized, to show that the antibodies were what caused the symptoms

Does anyone have any other links? I'm dying to know what was different about that mouse!!!!!

something about Malassezia in relationship to eczema. http://www.ncbi.nlm.nih.gov/pubmed/16354952?dopt=Abstract The role of sensitization to Malassezia sympodialis in atopic eczema. Phylogenetically conserved allergen structures, such as manganese superoxide dismutase, may play a role as cross-reactive allergens in a subset of AE patients as a result of molecular mimicry and cross-reactivity with structurally related human proteins and might contribute to the perpetuation of the inflammatory skin reactions. The use of recombinant Malassezia allergens will contribute to elucidate the pathways of sensitization occurring in AE, the underlying immunological mechanisms governing IgE- and T-cell-mediated responses and may provide new therapeutic options to alleviate Malassezia-related symptoms in AE. I haven't read this yet, but plan to tonight. I'm suddenly remembering a little boy with horribly itchy ears. Somehow, I think I'm going to find that this was related http://cmr.asm.org/cgi/reprint/15/1/21.pdf Immunology of Diseases Associated with Malassezia Species

Many articles here today that I think others would be interested in reading. I pasted excerpts from just a few below http://www.vaccinationnews.com/ http://www.naturalnews.com/026818_vaccinat...lu_vaccine.html Preliminary Injunction to Halt Mandatory Flu Vaccination in the U.S. Has Been Issued http://www.smh.com.au/environment/annual-v...90810-efms.html Annual vaccinations could be harmful: vets told On August 1 the Herald published a story in which veterinary academics warned Australian pet owners they were over-vaccinating. Since 2007, the international association has recommended that core vaccinations - for canine parvovirus, distemper and hepatitis in dogs and feline calicivirus, herpesvirus and parvovirus in cats - be administered no more than once every three years, and less frequently if possible. Annual vaccinations for these diseases were unnecessary medical intervention, the association ruled, and exposed an animal to more risk of an adverse reaction. Recent research has also pointed to links between over-vaccination and injection-site tumours in cats and immunological diseases in dogs. * ►August 10, 2009 - Avian Influenza Strain Primes Brain for Parkinson's Disease - St. Jude scientists report flu infection leaves brain more vulnerable later in life - press release - St. Jude Children's Research Hospital via PRNewswire-USNewswire - "'This avian flu strain does not directly cause Parkinson's disease, but it does make you more susceptible,' said Richard Smeyne, Ph.D., associate member in St. Jude Developmental Neurobiology. Smeyne is the paper's senior author. 'Around age 40, people start to get a decline in brain cells. Most people die before they lose enough neurons to get Parkinson's. But we believe this H5N1 infection changes the curve. It makes the brain more sensitive to another hit, possibly involving other environmental toxins,' Smeyne explained. Smeyne noted the work involved a single strain of the H5N1 flu virus, the A/Vietnam/1203/04 strain. The threat posed by other viruses, including the current H1N1 pandemic flu virus, is still being studied." Comment: If so, does the body distinguish between vaccine strains/doses and full-blown infection re: influencing Parkinson’s?

12+ years ago, i was taking an antibiotic for a sore throat/respiratory infection. About 4 or 5 days after finishing the antibiotic, i started itching all over. My head itched too. Went back to Dr. and he said that we had to assume it was an allergic reaction to amoxicillan. I asked if that could happen that long after finishing and he said we had to assume yes, and not to take any form of penicillan again. No rash of any kind with that episode. Took some zyrtec and that was end of it. I had developed a small itchy read spot on the back of my head/neck in my early 20's. No big deal, just used OTC cortizone cream occasionally. At some point, I got the spot on my elbow, which over the years did get quite big. Again, used mostly OTC cortizone and zinc oxide was pretty effective too. Then this past winter, I got the full body rash with an infection (strep strongly suspected) on that elbow. Within 24 hours of noticing red itchy bumps btwn my wrist and elbow, I was started on Prednisone & Keflex and a topical steroid. Probably a week+ into the rash, my head looked like a had a horrendous case of dandruff. Itchy, flacky mess. This type of psoriasis reaction is described by some on a psoriasis web group that I have been reading. Many have made the strep connection there too and it is recognized by some derms, except the ignorant ones who only know how to prescribe steroids and don't even realize the published studies showing the strep connection, again in some cases. Some derms have told patients that it crazy to think antibiotics would be helpful. I've read there that "in the old days" derms used to treat psoriasis with antibiotics frequently. With the steroid creams and fancy new drugs (TNF blockers etc.) it just isn't done much anymore. It makes me sad to think of how many people there might be on the "treat the symptom" highway, without getting to the underlying cause too. Some of the things used to treat psoriasis have some very nasty side effects. So, I ran across this just a few days ago, and it really got me wondering. Remember, I had no signs of psoriasis until I was around 21? bolding mine http://pt.wkhealth.com/pt/re/clei/abstract...#33;8091!-1 Pityrosporum ovale, aka Malassezia (from wiki) http://en.wikipedia.org/wiki/Malassezia Again, I've never had an invasive infection or anything that caused hypopigmentation before. But, I'm wondering if the antibiotic caused a disruption of skin flora which allowed this yeast to get out of control, or if there was just a hyper immune reaction to what is naturally there anyway, brought on by the antibodies produced in relationship to the original infection. When reading the study cited above, it says that sera from psoriasis patients were the ones who reacted this way, so I guess you would have to have the psoriasis factor there. My parents or siblings don't have psoriasis. Just wanted to share this, as I think it might be something to consider, since I see allergies to this and that medication mentioned here (seems) frequently. I don't think my reaction was related to amox. I think it was related to the infection (strep?) that caused the illness in the first place. Also, this makes me wonder how yeast/fungal infections could play into this whole thing.

http://74.125.95.132/search?q=cache:UiPi9k...=clnk&gl=us Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197Protein), Prevnar, is a sterile solution of saccharides of the capsular antigens of Streptococcus pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM197protein. Each serotype is grown in soy peptone broth. http://www.merck.com/product/usa/pi_circul...neumovax_pi.pdf 1 2 3 4 5 6B** 7F 8 9N 9V** 10A 11A 12F 14** 15B 17F 18C 19F** 19A** 20 22F 23F** 33F You can see below that Pneumovax is only on the schedule for "certain high risk groups" to be given after the age of 2 where the last dose of Prev, would/should have been given around 12 to 15 months. looks like 1 dose with a follow up single revaccination 5 years later for persons / children with functional or anatomic asplenia or other immunocompromising condition after 5 years. That info is provided in 2nd link ....Recommended Immunization Schedule for Persons Aged 7 Through 18 Years— Recommended Immunization Schedule for Persons Aged 0 Through 6 Years— http://www.cispimmunize.org/IZSchedule_Childhood.pdf Recommended Immunization Schedule for Persons Aged 7 Through 18 Years— http://www.cispimmunize.org/IZSchedule_Adolescent.pdf My youngest son who had full series of Prevnar has had pneumonnia twice. Trying to figure out how old he was. He also had a mystery illness (i think that was the phrase worried dad used) with a very low white count and fever edging 105. BTW, for anyone that didn't catch my mistake on previous post , adults are not given the Pneumococcal vaccine anually (oops... have never been that familiar with adult vaccine schedule!)

Well, rereading what I quoted, I think I'm wrong. I don't think they're saying that it would not dectect antibodies, only that the antibody formation would be due to a different component. Either way, I don't think we have the info that is really needed, which is how long is it reasonable to expect to find antibodies after a full couse of vaccination?

Well, rereading what I quoted, I think I'm wrong. I don't think they're saying that it wouldn't dectect antibodies, only that the antibody formation would be due to a different component . Either way, I don't think we have the info that is really needed, which is how long is it reasonable to expect to find antibodies after a full couse of vaccination?

Prevnar is bonded with or conjugated to diphtheria CRM197 protein. It is also absorbed on aluminum. This is done to prompt an immune response that wouldn't happen with a polysaccaride vaccine, such as the one discussed in the study above (can you see why it's said that immunization prompts a wholly unnatural immune response! shhhhsh). Depending on what type of test your child is getting, i don't think it would show immunity related to Prevnar vaccination. from above http://www.clinchem.org/cgi/content/full/53/3/505 (bolding and unlderlineine mine) I think the vaccine Peglem's daughter was given was a polysaccharide vaccine with no aluminum (please correct me if I'm wrong Peg). Sure'em not trying to discredit anyone's Dr. I'm sure they have good explanations for viewing the findings as they are, just trying to figure out if there is significance to the lack of evidence of immunity for Prevnar strains specifically.

This looks like it might contain some answers to the things I'm wondering about. Don't have time to pick out what I might be able to understand right now, but wanted to leave it in case someone else has idea's. http://www.clinchem.org/cgi/content/full/53/3/505 Bacterial capsular polysaccharides induce antibodies primarily by T cell–independent mechanisms. Therefore, antibody response to most pneumococcal capsular types is generally poor or inconsistent in children aged <2 years whose immune systems are immature. This is the reason why no children aged 2 years or less were included in the control group. The cutoff concentrations proposed in this manuscript are valid for children >4 years of age. To overcome the problem of nonresponsiveness in children younger than 2 years, a conjugated vaccine (Prevnar®) was developed. This contains 2 µg of serotype 4, 9V, 14, 18C, 19F, and 23F and 4 µg of serotype 6B. Use of the conjugated vaccine will have an influence on the choice of serotypes to diagnose specific anti–caps-PS antibody deficiency. Once a patient has been vaccinated with Prevnar, the serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F can no longer be used for antibody measurement, because the evaluation would assess the response to protein antigens rather than to polysaccharide antigens. For patients who have previously been vaccinated with the conjugated vaccine, other serotypes must be chosen. Uddin et al. compared the total pneumococcal IgG antibody, IgG subclass antibody titers, and serotype-specific antibody concentrations (4, 6B, 9V, 14, 18C, 19F, 23F, 1, and 5) in children who had received 2 doses Prevnar followed by a dose of Pneumovax to evaluate the most useful assays in clinical practice (25). They determined that children after Prevnar vaccination produced mostly IgG1 antibodies in contrast to the IgG2 antibody response to natural infection with S. pneumoniae or pneumococcal polysaccharide vaccines. Uddin et al. concluded that serotype-specific IgGs were useful in determining protection against specific pneumococcal strains, and showed that Pneumovax did not broaden protection against non-Prevnar serotypes (25). The increased clinical use of Prevnar and possible use of the next generation conjugated vaccines, such as 9-valent (26)(27)(28) and 11-valent (29), will make it necessary to determine the response to additional serotypes in the future. On the other hand, potential new antigens for vaccine formulations, such as the surface proteins PspA, PspC, PsaA, pneumolysin, BVH-3, and BVH-11, will also need the establishment of reference values. In conclusion, we established reference intervals for the specific antipolysaccharide immune response to 5 serotypes. Among 76 healthy controls (3–30 years of age), 75 adequately responded to at least 2 of these 5 serotypes, and 73 (96%), of the controls responded to at least 3 of these 5 serotypes. Patients who did not respond to at least 4 of the 5 serotypes were diagnosed as nonresponders.

I wonder if anyone knows more about this than I do, or can get clarification from a Dr? I'm questioning how long you would expect to see elevated titers from a Prevnar? When you think about it, older adults get a P. shot annually not a series, then you're done. I know they figure immunity wanes more quickly in older adults, however with Prevnar, I think it's given at a time frame where they figure "protective anitbody" formation is possible (i.e. if given earlier immune system doesn't respond due to age) and they keep giving it until they figure the child is out of the woods so to speak, because if protective levels decline (after that 4th immunization) the child will be old enough that it's no big deal to fight off the P. The other thing, "titer' levels are not always indicative of "protection." You may see low or absent levels but the when the body encounters a particul antigen again, it "remembers" it, because it has seen it before (i think this is the theory, personally i question if any of these vaccines work nearly as well as we've been lead to believe). Relying on a vaccine where the series had been completed some years prior, seems like it could have some problems. Also, the types that are showing as positive, may have been naturally occuing that the children had from natural exposure???? This is what is making me wonder if a challenge vaccine would be necessairy as Peglems's daughter had. I found one article that touches on what I'm talking about here, altho it's not that great because it's talking about a 23 valent vaccine, Prevnar is 7. It's talking about older adults etc. but i think it helps to clarify what I'm questioning. I guess if my child was given a diagnosis of PID based on the results of this type of testing, I would want to know what levels are in children not suspected of immune funtion problems. Maybe someone can find a better study specific to Prevnar? I would really like to understand this whole thing! http://74.125.95.132/search?q=cache:-5O42q...=clnk&gl=us Page 6 Efficacy and effectiveness also page 8 Durability of immune response and duration of protection PPV23 induces an initial rise in antibody titres, which decline over time. In older adults, antibody titres mea-sured 4–7 years after vaccination tend to approximate pre-vaccination baseline titres. The clinical significance of this decline in detectable antibodies is not clear since immune correlates of protection for pneumococcal polysaccharide vaccine have not been established and relatively limited clinical data are available regarding the duration of vaccine-induced protection against IPD.Of the 2 observational studies that evaluated the dura-tion of clinical protection induced by PPV23, 1 found that effectiveness declined with age (>65 years) as wellas with increasing time (3–5 years) since vaccination;the other study found that vaccine effectiveness was stable over time (>9 years), although the confidence limits around the point estimates of the vaccine effec-tiveness at different time points were wide.19, 30Revaccination may be needed because PPV23, like other polysaccharide vaccines, is not believed to confer long-lasting protection and because the incidence of pneu-mococcal infection in adults increases substantiallywith age

Interesting /informative article on CLO vit A & D ratios http://www.etownchiropractic.com/newsarticle.asp?ID=10

Nancy, Sounds to me like they may very well work in different ways, almost opposite mode of action?????? If NAC helps to increase the intracellular levels of glutathione also (an effect that I wouldn't think Riluzole would have) well, that may be having an effect too. I sure understand your concern though, and don't know if my interpretation is even close to accurate. Probably a good question for one of your daughter's Drs. http://www.answers.com/topic/riluzole trade name: Rilutek; drug class: glutamate antagonist; action: inhibits presynaptic release of glutamic acid in central nervous system; use: treatment of amyotrophic lateral sclerosis (Lou Gehrig disease). http://www.ncbi.nlm.nih.gov/pubmed/1958156...Pubmed_RVDocSum N-acetylcysteine, an amino acid, seems to restore the extracellular glutamate concentration in the nucleus accumbens and, therefore, offers promise in the reduction of compulsive behavior.

Opps, forgot to include link for the above quote and probably the most important part! http://www.jneurosci.org/cgi/content/abstract/27/47/12808 and (bolding mine)

From Colleen's post I do too, and I'll tell you a bigger fear. If you decline on the first round, I'm afraid there's a possibility that by the time it becomes mandatory, only the vaccines that contain a squalene adjuvant will be available (not saying this is going to happen only afraid it could). Scares me to think, whether the threat is real or hyped that eventually they are going to force all of the stock piled supplies to be used. Can you imagine the $$$$ involved in mass vaccination of the world? With the world economic problems, how would a wasted rush to manufacture and plans to dispense just fizzle? I hope everyone is reading this page (and anything else you can find) daily, so you are well informed on this situation. http://www.vaccinationnews.com/ Here are a couple of related studies. The shark liver oil is a source of squalene. Big difference btwn injected and ingested, but this study is very relevant IMHO, inlight of the autoimmune aspect. http://www.ncbi.nlm.nih.gov/pubmed/1612438...Pubmed_RVDocSum On the bases of these observations, we propose that shark liver oil supplementation in high doses is beneficial in bacterial, viral and fungal infections, whereas patients with atherosclerosis or autoimmune diseases should avoid the consumption of high amounts of shark liver oil. http://www.ncbi.nlm.nih.gov/pubmed/1519416...Pubmed_RVDocSum Microbial components, not the adjuvant components, are considered to be of primary importance for adverse effects of vaccines. We have reported that a single intraperitoneal injection of the adjuvant oils pristane, IFA or squalene induces lupus-related autoantibodies to nRNP/Sm and -Su in non-autoimmune BALB/c mice. Induction of these autoantibodies appeared to be associated with the hydrocarbon's ability to induce IL-12, IL-6, and TNF-alpha, suggesting a relationship with hydrocarbon's adjuvanticity. Whether this is relevant in human vaccination is a difficult issue due to the complex effects of vaccines and the fact that immunotoxicological effects vary depending on species, route, dose, and duration of administration. Faith, if you're reading I promise I will scout for your message first thing in the morning (well after sunrise anyway, I guess it IS morning!!!!)

You're welcome and I hope you'll keep us updated whether you find any change with usage! I hope there is more promising news on this front http://clinicaltrials.gov/ct2/show/NCT00627705 A Study of N-Acetyl Cysteine in Children With Autism This study is currently recruiting participants. Verified by Stanford University, March 2009

Peg, We've probably been traveling down some of the same paths, but this in particular really caught my attention. Seems there's something important here. bolding mine http://www.medicalnewstoday.com/articles/106098.php Neurobiology of Disease Methionine Sulfoxide Reductase A and a Dietary Supplement S-Methyl-L-Cysteine Prevent Parkinson's-Like Symptoms I have several more snippets of info....not sure anything is really helpful. I can spend hours going round and round with info like this and ultimately and get no where. I'm going to leave most of what I have here in case we have a "Buster" who can make any sense of it. I'm coping these as I had them saved. http://www.medicalnewstoday.com/articles/141710.php Shedding Light On Heart's 'Fight Or Flight' Response To Stress http://www.sciencedirect.com/science?_ob=A...2c3bc2e7d82652a Effect of diabetes on calcium/calmodulin dependent protein kinase-II from rat brain http://en.wikipedia.org/wiki/Ca2%2B/calmod..._protein_kinase http://www.nature.com/npp/journal/v32/n12/full/1301378a.html Chronic Antidepressants Induce Redistribution and Differential Activation of CaM Kinase II between Presynaptic Compartments and

Nancy, I was going to include this article in a response to Peglem's CamKinaseII thread, but don't remember seeing it here (altho I may well have missed discussion on it). http://latimesblogs.latimes.com/booster_sh...airpullers.html and I saw your recent remark about NAC not appearing to work for your daughters OCD. I'm wondering if you could say how much you have been using for how long?

MLA, I have heard of it and had my kids tested. One was high, but he had eaten prior to the blood draw. I was mainly interested because of the way one child shuns protein (high ammonia levels can indicate a problem with protein metabolism). His level was normal. I have wondered if the level was normal precisely because he consumes so little protein. If you do a search with the words: Alpha-Ketoglutaric Acid ammonia autism or N acetyl cysteine ammonia autism you'll get lots of info. My reg Ped seemed alarmed when he looked at the report that showed an elevated reading (until I told him that he had breakfast prior to draw). That is a test result that will get attention from even reg ole Dr.s. It can be a serious problem. Did you get a recommendation on treatment?

I'm terrified to think what may happen to our kids (and even our adult population in regards to two or possibly 3 flu vaccines along with Pneumococcal vaccine etc.) IF they end up getting a regular flu vaccine, two doses of the H1N1, HPV. menningitis, etc. I'm talking about kids with no known autoimmune conditions, not to mention ones with known problems! Another HUGE concern of mine is the possibility that squalene might be used as an adjuvant in some of these vaccines (more on that below). I was looking at some of the clinical trails planned for H1N1 and have to notice the EXCLUSIONS as usual......Also notice that an allergy to thimerosal/mercury (and this is for a pediatric trial) is listed. http://clinicaltrials.gov/show/NCT00944073 Exclusion Criteria: Have a known allergy to eggs or other components of the vaccine (including gelatin, formaldehyde, octoxinol, thimerosal and chicken protein). Have a positive urine or serum pregnancy test within 24 hours prior to vaccination or are breastfeeding. Have immunosuppression as a result of an underlying illness or treatment, or use of anticancer chemotherapy or radiation therapy (cytotoxic) within the preceding 36 months. Have an active neoplastic disease or a history of any hematologic malignancy. Have long term use of glucocorticoids including oral, parenteral or high-dose inhaled steroids (> 800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding 6 months. (Nasal and topical steroids are allowed.) Have a diagnosis of schizophrenia, bipolar disease, or other major psychiatric diagnosis including major depression. Have been hospitalized for psychiatric illness, history of suicide attempt, or confinement for danger to self or others. Are receiving any psychiatric drugs (aripiprazole, clozapine, ziprasidone, haloperidol, molindone, loxapine, thioridazine, thiothixene, pimozide, fluphenazine, risperidone, mesoridazine, quetiapine, trifluoperazine, chlorprothixene, chlorpromazine, perphenazine, trifluopromazine, olanzapine, carbamazepine, divalproex sodium, lithium carbonate or lithium citrate) or any drugs for treatment of depression. Have a history of receiving immunoglobulin or other blood product within the 3 months prior to vaccination in this study. Received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to vaccination in this study or expect to receive an experimental agent during this study (prior to the Day 201 follow-up call - 180 days after the second vaccination). Have received any live licensed vaccines within 4 weeks or inactivated licensed vaccines within 2 weeks prior to vaccination in this study or plan receipt of such vaccines within 21 days following the second vaccination. and....... bolding mine (oops for some reason, I can't use the bold or quote feature. This next paragraph would be bolded if I could!!!!!!!! Have an acute or chronic medical condition that, in the opinion of the investigator, would render vaccination unsafe, or would interfere with the evaluation of responses. (This includes, but is not limited to, known cardiac disease, chronic liver disease, significant renal disease, unstable or progressive neurological disorders, diabetes mellitus, autoimmune disorders and transplant recipients.) Have a history of severe reactions following previous immunization with influenza virus vaccines. Have an acute illness, including an axillary temperature greater than 100 degrees Fahrenheit or an oral temperature greater than or equal to 101 degrees Fahrenheit, within 1 week of vaccination More clinical trails can be found here: http://www.clinicaltrials.gov/ct2/results?term=H1n1 Notice how many times you see the phrase "healthy adults/ healthy children" This headline makes my hair stand on end from that page. Also note how many people are involved in the trials, the time frame of noted adverse reactions. Some of them won't be completed until well after they plan to start injecting this into the masses! *Trial to Assess Safety, Tolerability, and Immunogenicity of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold-Adapted (FluMist) and Measles, Mumps, Rubella, and Varicella Vaccines Administered Concurrently to Healthy Children* SQUALENE http://anthraxvaccine.blogspot.com/ Two new adjuvants being prepared for a pandemic flu vaccine (ASO3 and MF59) contain "oil in water" emulsions. The oil is squalene, which is a cholesterol precursor. However, when injected, squalene may cause arthritis or autoimmune effects. The US government recently promised to purchase 119 million doses of ASO3 and MF59, made by Glaxo-Smith Kline and Novartis, for new pandemic flu vaccines. Who is Meryl Nass, MD Diplomate, American Board of Internal Medicine http://docs.google.com/Doc?docid=ac3k73cqj...xb3g6&hl=en * ►July 23, 2009 - U.S. has bought 195 million doses of H1N1 vaccine - Reuters - "The U.S. Health and Human Services Department has also contracted for 120 million doses of adjuvant, a compound to stretch the number of doses of vaccine needed, the department's Dr. Robin Robinson told a meeting of Food and Drug Administration advisers." Such an excellent resource!!!!!!!! http://www.vaccinationnews.com/ From recent headlines on this page * ►July 26, 2009 - Drug firms dodge swine flu liability - The Scotsman - "The UK government has been forced to accept legal liability for the swine flu vaccine amid concerns it could trigger life-threatening side-effects among the population at large. Ministers have taken on all the risk for the 60 million doses they have ordered from GlaxoSmithKline and the Baxter group, after both firms said they would refuse to produce it unless legally protected."