Can anyone explain what Anti-neuronal Antibody Titers

[tapiash]

Anti-Lysoganglioside 2 hours

patient 640

positive control >1280

negative control 80

normal range 80-320

normal mean 147

 

Anti-Tubulin 2 hours

patient 2000

positive control 16000

negative control 250

normal range 250-1000

normal mean 609

 

Anti-Dopamine 1 2 hours

patien 4000

positive control 8000

negative control 1000

normal range 500-2000

normal mean 1056

 

Anti-Dopamine 2 2 hours

patient 4000

positive control 16000

negative control 2000

normal range 2000-16000

normal mean 6000

[justinekno]

Is this the second part of your Cunningham results?

 

Anti-Lysoganglioside 2 hours

patient 640

positive control >1280

negative control 80

normal range 80-320

normal mean 147

 

Anti-Tubulin 2 hours

patient 2000

positive control 16000

negative control 250

normal range 250-1000

normal mean 609

 

Anti-Dopamine 1 2 hours

patien 4000

positive control 8000

negative control 1000

normal range 500-2000

normal mean 1056

 

Anti-Dopamine 2 2 hours

patient 4000

positive control 16000

negative control 2000

normal range 2000-16000

normal mean 6000

[tapiash]

Is this the second part of your Cunningham results?

 

Anti-Lysoganglioside 2 hours

patient 640

positive control >1280

negative control 80

normal range 80-320

normal mean 147

 

Anti-Tubulin 2 hours

patient 2000

positive control 16000

negative control 250

normal range 250-1000

normal mean 609

 

Anti-Dopamine 1 2 hours

patien 4000

positive control 8000

negative control 1000

normal range 500-2000

normal mean 1056

 

Anti-Dopamine 2 2 hours

patient 4000

positive control 16000

negative control 2000

normal range 2000-16000

normal mean 6000

 

 

 

Yes. My DS CAm K was 161

[bronxmom2]

Wow, my son's number's were exactly the same, including the CamK.

[fuelforall]

Don't know if this discussion is helpful to you. Hope it is.

 

http://www.latitudes.org/forums/index.php?...art=#entry44391

[Buster]

Hi Tapiash,

 

I can try to explain the titers, but what they mean isn't quite known yet.

 

Dr. Cunningham is running what is known as Competitive Inhibition ELISAs -- this is a fancy term for seeing who gets there first.

 

 

While not perfectly the same, this is sort of similar to what happened when you did titration experiments in high-school chemistry.

 

 

What they do is take a substrate of a chemical like a "lysoganglioside". And then have a known quantity of a chemical that changes colors when it binds to the lysoganglioside. They choose the concentration of this chemical to create a pronounced change in the tube. If there was none of your serum added, and only the chemical added, the tube would change colors.

 

Now they take your serum and start diluting it by powers of 2 into each tube. In this way they have very weak concentrations and very strong concentrations. They first add this "diluted serum" and then try to add the "color change chemical". Since the diluted serum is already bonded to the lysogangliosides there's no room for the color changing chemical to attach and so the color doesn't change. They keep diluting the concentration of serum until there's a color change. So the number being reported is the amount of dilution needed before the serum didn't "interfere" with the color change.

 

 

So 640 and 1280 are just one dilution away. So too are 8000 and 16000. Generally they don't look closer.

 

In terms of your numbers, the serum interfered a bit with lysogangliosides (slightly elevated), was within norm for tubulin, was slightly elevated for anti-D1, and normal for D2. Beyond that, we don't know a lot more.

 

 

Probably more than you ever wanted to know and not what you actually wanted to know...

 

Buster

 

 

Anti-Lysoganglioside 2 hours

patient 640

positive control >1280

negative control 80

normal range 80-320

normal mean 147

 

Anti-Tubulin 2 hours

patient 2000

positive control 16000

negative control 250

normal range 250-1000

normal mean 609

 

Anti-Dopamine 1 2 hours

patien 4000

positive control 8000

negative control 1000

normal range 500-2000

normal mean 1056

 

Anti-Dopamine 2 2 hours

patient 4000

positive control 16000

negative control 2000

normal range 2000-16000

normal mean 6000

[kimballot]

I just re-found this post for someone and thought I'd bump it up. It was a great chunk of info. from Buster a few months back and some may not have seen it!