Vitamin C

[Laurensmom]

Recently my daughter saw quite an increase in tics. I started to administer about 1000 mg of vitamin C about four days ago and I've seen a dramatic improvement. Each day tics have diminished. Now they're barely notable again.

 

Has anyone else used vitamin C with any degree of success? I decided to try it given I think PANDAS may be an issue for us and I wondered how the vitamin would impact my dd if there was an auto immune component to her issues.

 

It's probably a coincidence but there was a rapid improvement so I wanted to bounce it off the group.

 

Thanks in advance for your feedback.

[Stephanie2]

If I had to guess, the Vit. C did one of two things: enhanced the immune system's ability to fight off anything that may be lurking and causing pandas symptoms at the moment, OR improved her ability to deal with allergies (which also exacerbate pandas symptoms). That is great news, maybe I need to bump up my kid's Vit. C intake!

 

Stephanie

 

Recently my daughter saw quite an increase in tics. I started to administer about 1000 mg of vitamin C about four days ago and I've seen a dramatic improvement. Each day tics have diminished. Now they're barely notable again.

 

Has anyone else used vitamin C with any degree of success? I decided to try it given I think PANDAS may be an issue for us and I wondered how the vitamin would impact my dd if there was an auto immune component to her issues.

 

It's probably a coincidence but there was a rapid improvement so I wanted to bounce it off the group.

 

Thanks in advance for your feedback.

[Laurensmom]

Thanks for the feedback Stephanie. I'm planning to continue experimenting with vitamin C when we see an increase.

 

I'll keep you all posted.

[trggirl]

Thanks for posting this! It will be interesting to see what happens.

[kim]

Some of us have struggled with the question of overactivating the immune system as opposed to suppression when autoimmunity is suspected. I think it's important to look at the big picture (to the best of our ability) I thought this was one good example.

 

bold mine

http://www.kinaseresearch.com/showabstract.php?pmid=11120850

 

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activate

 

The transcription factor NF-kappaB is a central mediator of altered gene expression during inflammation, and is implicated in a number of pathologies, including cancer, atherosclerosis, and viral infection. We report in this study that vitamin C inhibits the activation of NF-kappaB by multiple stimuli, including IL-1 and TNF in the endothelial cell line ECV304 and in primary HUVECs.

 

http://www.biomol.de/wiki/index.php/NF-kap...bitory_Peptides

 

NF-kappaB has been shown to regulate the expression of a number of genes whose products are involved in inflammation, viral replication, carcinogenesis, anti-apoptosis, invasion, and metastasis.

Specific adhesion molecules, chemokines, inflammatory cytokines, and cell cycle regulatory genes are also affected. Thus, agents that can suppress NF-kappaB activation have the potential to be treatments for inflammatory diseases and cancer

 

 

Vit C given to bowel tolerence during illness like H1N1 was recommended by someone with an opinion that I trust a lot. Many of the complications that are seen with illness (pneumonia, Flu etc.) are the result of inflammation, not an overwhelming invasion by the pathogen (my understanding).

Edited May 4, 2010 by kim

[kim]

This one looks really interesting but I can't make much of it past the title as it was really making my head hurt

I won't mention any names, but I know we have at least on poster here that is familiar with tyrosine hydroxylase and this person is very smart, so maybe he'll tell us if this has any significance in a situation of upregulated tyrosine converting to too much dopamine? (EAmom....will flattery work?)

 

 

http://www.kinaseresearch.com/showabstract.php?pmid=2901463

 

Inactivation of tyrosine hydroxylase activity by ascorbate in vitro and in rat PC12 cells.

Edited May 5, 2010 by kim

[H Mom]

My daughter had IVIG with Dr. K 3 weeks ago and he recommended 250 mg of vitamin C (specifically Ester C) daily for 6 weeks post IVIG.

[Laurensmom]

Posting this for the record given the potential histamine connection.

 

http://selfdevelopmentedge.com/the-role-of...min-c-part-iii/

 

The contents of this dissertation have introduced a multidimensional model for the attenuation of histamine-related mental illness via vitamin C supplementation. Both histamine and vitamin C affect the human body on multiple levels. Histamine plays many different roles in the body, including neuromodulation, neurotransmission, allergic mediator, inflammatory mediator, and gastric acid secretion stimulator. When histamine levels are in the normal range, the above processes are usually in equilibrium and functioning optimally. It is when histamine levels become too low or high that trouble can arise. One of the roles of vitamin C in the body is to modulate histamine levels; if histamine levels are low, vitamin C administration will cause small amounts of histamine to be released. When histamine levels are abnormally high, vitamin C acts as an antihistamine, destroying excess histamine and thus bringing this chemical down to normal physiological levels.