kryptopyrrole testing

[ellen hanson]

Hi may name is ellen hanson. I am the president and laboratory supervisor for Direct Healthcare access II Lab Inc. 350 W. Kensington Road Suite 107 Mount Prospect IL 60056 847-222-9546 Fax 847-222-9457 e mail dha1825@aol.com

 

We specialize in Urinary Kryptopyrrole Testing and Direct Absolute Basophil Testing.

 

Elevated urinary Kryptopyrrole is an important biochemical marker "frequently identified" in autism, asperger's syndrome and other mental and emotional conditions.

 

Kryptopyrrole depletes the body of Zinc and Vitamin B-6.

 

Utilize Kryptopyrrole testing for best care.

 

We have established a specialized laboratory serving the Health Research Institute d.b.a. Carl Pfeiffer Treatment Center.

 

Our laboratory director and supervisor are pioneers in the performance of kryptopyrrole testing going back to the mid-1970's.

 

Price Schedule Kryptopyrrole Urinary Quantitative $40.00

 

Direct Absolute Basophil $35.00

 

Pricing includes testing, customized specimen collection kits, and personalized service.

 

If you are interested in sending specimens to our laboratory or if you have a test that you would like to have performed that is not readily available, we are able to develope customized laboratory procedures. Please call or e mail us.

 

Thank you for considering us for your testing needs

 

Ellen Hanson

[Sheila]

Thank you for giving us this information on your lab testing, Ellen.

[Claire]

Ellen,

 

What reading does your lab consider abnormal? I have heard >20, then someone said that 10-20 is a borderline.

 

How long must the person be off supplements for a valid reading? I have heard 3 days, and I have heard 3 weeks? Must they be off all supplements or just those containing zinc and B6?

 

Also, what do the zinc, B6, Vit C and E supplements actually do for Pyrollia? Do they 'cure it' by killing or correcting something, and if so, how long does it take? Or is Pyrollia a chronic condition for which the supplements are required on an ongoing basis.

 

Do you have any links to related studies, e.g. the autism one that you mentioned?

 

Claire

[Chemar]

Hi

I need clarification

 

I see Claire has referred to "pyrollia"

 

I have not heard of this before.

 

I know of "pyroluria"

 

are these the same thing??

 

and Ellen

 

the tests you are referring to....

 

is this for what I know as PYROLURIA??

or something else.

 

thanks for the clarification

I just want to be sure I have it correct before I refer folks here.

[Claire]

Chemar,

 

I just misspelled it (e.g. missed the syllable)--I have never gotten that name down in my head and keep spelling it that way. I had never heard of the "Urinary Kryptopyrrole" in Ellen's post but was assuming it was the same thing, based on Sheila's earlier post.

 

On my form Biocenter calls it 'testing for Urinary Pyrolles', and that is what I was asking about anyway.

 

Claire

[Heather]

Yes, Ellen Hanson is the woman I was speaking with earlier on the phone today. I asked her about the condition "pyroluria" and this is the test that she is referring to. It is a measure of kryptopyrrole in the urine.

 

Heather

[Chemar]

thanks for the clarification Claire!

 

I got my Omega 3s & 6s mixed up the other day and so I wanted to be real sure I understood before I pointed folks to this as a pyroluria test info thread!

[ellen hanson]

June 17, 2004

 

I will try to answer each question. Please understand I am not a physician, I do not treat patients. I am an independent clinical laboratory that has been doing kryptoyrrole testing since the mid-1970's. I am a Medical Technologist, I personally run the procedure and treat each specimen as if it was my own.

 

I will answer your questions with information I have read.

 

Literature indicates most persons have less than 10 mcg of Kryptopyrrole per deciliter. Persons with 10-20 are considered "borderline" pyroluric and may benefit from treatment depending on their clinical symptoms. Persons with levels above 20 mcg/dl are considered to have pyroluria, especially if symptoms are present.

 

To make an initial diagnosis, no vitamins or minerals should be taken two days before the urine is collected.

 

According to Natural Healing for Schizophrenia and other common mental disorders by Eva Edelman Forwarded by Abram Hoffer, M.D., PhD.

 

Pyroluria is characterized by excess urinary Kryptopyrrole. *Kryptopyrrole binds irreversibly with B6. The resulting compound combines with any available zinc, and is excreted in the urine, thus severely depleting the body of both B6 and zinc.

 

Zinc is required in the development of nerves, nucleus formation, and collagen and protein synthesis. It promotes resistance to stress and disease, supports thyroid and insulin activity,as well as intellectual functioning, helps moderate moods, and benefits some types of headaches. With manganes, zinc chelates copper and supports histamine storage. Zinc also maintains the senses of taste and smell. Deficiency has been associated with paranoia, memory problems, irritability, behavior disorder, joint pain, immune dysfunction and carbohydrate intolerance.

 

Manganese is necessary for blood sugar regulation, sugar and protein metabolism, joint and cartilage development, prevention of autoimmune disorders and allergies, bone growth, thyroid function, and the moderation of depression. It makes choline available to form the neurotransmitter acetylcholine, needed to conduct impulses between nerves and muscles and important in memory function. Manganese deficiency has been associated with fatigue, dizziness, glucose intolerance, joint malformation, seizures and incoordination.

 

Vitamin B-6 is used in cerebral detoxification; the metabolism of carbohydrates, fats and all amino acids; and in RNA and DNA synthesis. B6 supports formation of a number of important neurotransmitters, including serotonin, dopamine, norepinephrine, acetycholine and GABA. B6 also supports the thyroid, helps maintain immune functioning, and is essential to hemoglobin and steroid synthesis. Deficiency can induce nausea, tingling shock-like sensations in the limbs., and childhood convulsions. B6 has been used in treating hyeractivity, epilepsy, depression, agitation, autism, cerebral allergies, childhood schizophreniz, pyroluria and histamine imbalances.

 

Treatment, focuses on vitaminn B6, zinc and manganese. According to Pfeiffer, pyroluria is easily treatable and patient improvement is directly related to the reduction in urinary kryptopyrrole. Pyrolurics often respond to nutritional treatment within one to seven days, and may totally recover within three to four months, barring confounding conditions, e.g. heavy metal toxicity or a histamine imbalance.

 

Nutrient treatment should be maintained, and increased when undergoing stress, to avoid relapse. If zinc and B6 supplementation is discontinued, a rapid return of serious symptoms usually occurs within two days to two weeks.

 

IMPORTANT

SUPPLEMENTATION NEEDS TO BE DIRECTED BY A DOCTOR AS TOO MUCH CAN BE TOXIC, USE OF THE WRONG FORM WILL BE INEFFECTIVE AND AVOIDING COMPETING MINERALS AND SUPPLEMENTS MAY BE NECESSARY.

 

Links to related studies

www.hriptc.org or 630-505-0300

 

 

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Clarification

 

Urinary Kryptopyrrole measurments are used to diagnose pyroluria, along with physical examination to observe the patient for physical signs of pyroluria, and a medical history to evalute symptoms of pyroluria.

 

Maybe Claire referred to it as pyrollia in error

 

Yes we do the test Kryptopyrrole for pyroluria. Pyroluria is characterized by an increase in urinary Kryptopyrrole.

 

Honestly I don't know what procedure BioCenter lab is running so I can't comment on their form as you indicate they call it urinary pyrolles

 

I don't understand the Omega 3s & 6s mix up. If you could clarify I could try to get you an answer.

 

Kryptopyrrole Specimen Collection Requirements

 

The specimen container has a preservative of ascorbic acid.

 

The specimen is sensitive to light. My directions require the specimen be immediately frozen upon collection. Therefore, by placing the specimen in the freezer it is not exposed to light. When it is removed from the freezer and put in the styrofoam kit again there is little to no light exposure. So I don't find the light a issue, because the directions, if followed, do not expose the specimen to light.

 

Freezing is critical and keeping that specimen frozen is critical. I don't care what any other lab is doing. I know that studies performed in our laboratory determined that specimens received not frozen "average" 27% lower than frozen specimens. I do know I was very curious about BioCenter lab so I split two specimens one I ran here and one I sent to BioCenter Lab following there directions, my result was 12.0 there results was 2. So I really don't want to comment on any other laboratory expect mine.

 

I hope I have answered your questions.

 

Wishing all of you a great day.

 

Respectfully,

 

 

Ellen Hanson

[Claire]

Hi Ellen,

 

That was a GREAT explanation, thanks! I finally 'get' the zinc/B6 correlation. For myself and others here: Do you require a doctor's signature to order a kit?

 

I agree that the doctor should supervise supplements. Question though: Does the lab make supplement recommendations with the test results? My alternative doctor is great and has heard of pyroluria, but has never ordered tests for it, so I am not sure he would know the supplements to give--or how much.

 

By the way, what is "Direct Absolute Basophil Testing" all about? (Not sure if it applies here or not).

 

Thanks,

Claire

 

ps, Yes I meant pyroluria, not pyrollia. Also, re the Omega 3/6's, Chemar was referring to a conversation on an unrelated thread that has nothing to do with this--her comment was to me, not you.