Now Salmon Oil

[Spartan32]

Hey, I wanted to try and start taking omega 3's and saw controversy over taking flaxseed/evening primose or fish oils. I found this one for cheap at a local store and was wondering if this would bew a good source of omega 3's or be negative and make my tics worse.

 

http://www.nowfoods.com/?action=itemdetail&item_id=3558

 

Thanks

[Chemar]

hi Spartan

 

salmon oil is an excellent source of omega 3 and if you tolerate it well...it will be very beneficial.

 

Unfortunately, you really wont know if you areone of those people who tic more with fishoil until you try it

 

If after about 3 days being on it you notice a significant increase in tics, then it is likely you are reacting, and would therefore be better off with flaxseed oil(preferably in combo with borage)

 

My son can eat all the fish he cares to (and he loves it) but if he goes near supplemental fishoil of any form, he tics a LOT more almost immediately!

[kim]

I had posted a while back that Daniel had sent me some information which could explain why fish oil caused some people to tic more, while apprearing to be helpful for others. I went back and found most of what he had sent.

 

 

 

From Bonnie's site

 

http://www.bonniegr.com/Interview%20with%20Bonnie.htm

 

 

NMDA receptor activation leads to increased release of dopamine in the striatum and modulates dopaminergic transmission in the striatum involving the D2 dopamine receptors implicated in TS. In a study by McGrath, a mouse model of comorbid TS and OCD was produced by increasing brain glutamatergic activity.

 

The next year I added EPA and DHA (essential fatty acids found in fish oil) to his regimen because of the studies showing that magnesium deficiency causes essential fatty acid deficiencies and another study showing that dopamine was inhibited from binding to D2 receptors by fish oil. Grape seed extract was needed as an additional antioxidant to help heal oxidative damage from a possible magnesium deficiency, combat allergy, and to prevent auto-oxidization of DHA and EPA in the gut. An interesting thing occurred, he immediately started completing and handing in his homework on time. His grades improved greatly and he no longer needed his allergy shots.

 

 

From this article: ADVANCES IN UNDERSTANDING BRAIN CIRCUITS RESPONSIBLE FOR TICS IN TOURETTE'S SHED LIGHT ON DISORDER

 

http://apu.sfn.org/index.cfm?pagename=news_102504b

 

Knowing that dopamine antagonist drugs reduce the tics associated with Tourette's and that selective serotonin reuptake inhibitors reduce the symptoms of obsession and compulsions, Roger Albin, MD, and colleagues at the University of Michigan department of neurology investigated the idea that the ventral striatum¡a brain region where both dopamine and serotonin have important functions¡could be involved in Tourette's syndrome.

 

 

 

THEN

 

http://scholar.google.com/scholar?hl=en&lr...+to+d2+receptor

 

Chalon and coworkers increased the ratio of omega-3 to omega-6 PUFA by using fish oil plus palm oil in the diet (50). This resulted in increased dopamine receptors as well as

increased dopamine levels in the cerebral cortex. By contrast, however, this dietary strategy also decreased both ambulatory activity and dopamine binding in the striatum.

 

 

 

In humans the striatum is activated by stimuli associated with reward, but also by aversive, novel, unexpected or intense stimuli, and cues associated with such events. Recent fMRI evidence[citation needed] suggests that the common property linking these stimuli, to which the striatum is reacting, is saliency under the conditions of presentation. A number of other brain areas and circuits are also related to reward, including the nucleus accumbens and other frontal areas.

The main efferent target of the striatum is the pallidonigral system, which is primarily inhibited by GABAergic synapses from the striatum. The main afferent region to the striatum, through the thalamus, is the cortex by two separate channels: one through the medial pallidum to VO and from there to the SMA and another through the nigra reticulata to VA and from there to the frontal and the oculomotor cortex . Cortical pyramidal neurons (glutamatergic) project to the striatum, exciting striatal neurons. The substantia nigra projects dopaminergic axons to the striatum via the nigrostriatal pathway (a part of the medial forebrain bundle in rat no such entity exists anymore in primates). While cortical axons synapse mainly on spine heads of spiny neurons, nigral axons synapse mainly on spine shafts. Metabotropic dopamine receptors are present both on spiny neurons and on cortical axon terminals. Second messenger cascades triggered by activation of these dopamine receptors can modulate pre- and postsynaptic function, both in the short term and in the long term.

Parkinson's disease results from loss of dopaminergic innervation to the striatum (and other basal ganglia) and to the cascade of consequences . It is also thought that addiction involves plasticity at striatal synapses.

[Spartan32]

Hey, well I think I am going to go with a flaxseed oil to get my Omega 3's.. How does this look? I wasn't sure if this would be good (only offering Omega 3's) or to get a one that offers Omega 3-6-9's.

 

This is the one only offering the omega 3's.

 

http://www.bodybuilding.com/store/now/flax.html

 

Here is the one offering 3-6-9

 

http://www.bodybuilding.com/store/now/omega.html

 

 

Also serving size.. Should I follow what it says or take more than the serving size? Thanks

[Chemar]

Hi Spartan

 

it is good to take EFAs in balance and so the one with 3,6&9 would be my choice UNLESS you have any inflammatory issues, in which case you should stick with just the Omega 3

 

 

Start with the recommended daily dose and only go up after a week or 2 if needed