Back to celebrex

[melanie]

Ok so we went off celebrex and I definitly noticed a bit of a increase of behavioral symptoms.Not bad but more frusterated .So I thought why is it because the the IV is wearing off ,maybe,so I decided to start the celebrex again and bamm right back to our happy place .Not so sure why it works so well or if its that or not.This is usually our bad week Iv #13 friday, But if celebrex helps celebrex it is!! Just trowing it out there

 

Melanie

[EAMom]

Thanks for posting this. I've always wondered if Celebrex would help. It makes sense if Advil/ibuprofen helps Pandas kids, that some other NSAIDS might.

 

 

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001050

Celecoxib is in a class of NSAIDs called COX-2 inhibitors. It works by stopping the body's production of a substance that causes pain and inflammation.

 

Have you tried advil on Danny b-4? Is celebrex better? What made your doc rx it?

[Phasmid]

There is a study published somewhere out there in cyberspace, on a trial of cox 2 inhibitor for TS and it was pretty effective.

 

 

[EAMom]

Here's one with OCD/ and ibuprofen.

 

Supporting this, a case report is presented of a subject with OCD who developed comorbid paresthesia, for whose latter condition a regimen of ibuprofen was instituted. Thirteen weeks thereafter subject's OCD symptomatology had declined by 40% (YBOC scale) from baseline. Inasmuch as ibuprofen and numerous other non-steroidal anti-inflammatory drugs (NSAIDS) block brain neuronal prostaglandin synthase (several also inhibiting phospholipases A(2)and C), thereby reducing catabolism of neuronal membrane arachidonic acid, the ibuprofen apparently increased the integrity of subject's neuronal membranes, as would likely also be the case with EFA dietary supplementation.

 

http://www.ncbi.nlm.nih.gov/pubmed/11339839

 

PS Can anyone find the full-text?

[ForyouCG]

Hi Melanie, may I ask you how many milligrams of celebrex you are giving? My son's doctor prescribed it also, he prescribed 100mg. Do you know if it can cause stomach discomfort? My son had to stop taking Ibuprofen because it caused this and he gets alot of headaches due to inflammation, motor tics and some ocd.

Presently I am using natural anti-inflammatories.

Will appreciate any information...Thank you

 

Wishing you and your child the best...

[melanie]

I didnt know there were actual studies.I think Dr J started it thinking he had inflamation from his asthma(mild asthma)

 

The last visit she told us to stop,so we did but I started seeing him behaving a little more than he was so said let me see and so well it seems better

 

Melanie

[melanie]

Im at work so I dont know the mill..I will look when I get home.He also takes a baby asprin with the celebrex.She did prescibe it 2x daily but I only give it to him in the AM

 

Melanie

[melanie]

200 mg 2x daily i only give it 1x a day hes 135lbs 16 years old

[formedbrds]

T

Edited October 30, 2010 by formedbrds

[Chemar]

just do also be aware of the 2005 FDA alert on Celebrex

http://www.fda.gov/D...s/ucm124655.htm

 

as with so many meds, one has to weight the pros and cons and then make an informed choice

[smartyjones]

Presently I am using natural anti-inflammatories.

 

what natural anti-infammatories are you using? thanks.

[melanie]

But whats my choice,really? If this is helping ALOT what can I do

[EAMom]

But whats my choice,really? If this is helping ALOT what can I do

 

IMO, I wouldn't panic if I were you. From Chemar's link, it looked like 1 study found an increased risk of stroke etc (when celebrex was given 200mg or 400mg 2x daily). Another study found virtually no increased risk (when 400mg was given 1x daily) with a hazard ratio of 1.1 (1.0 would be no increased risk).

 

The risk certainly appears to be dose dependent, and Danny is taking a low dose for his size, which is good. No treatment (antibiotics, psych. drugs, nsaids, or even alternative treatments, IVIG, PEX) is guarenteed to be risk free. It is our job to make informed decisions and decide when the risks (however small or large they may be) outweigh the benefits.

 

If it is helping a lot, and Danny was my child, I would have no hesitation with continuing Celebrex at the dose he is taking.

 

Just MHO.

[Chemar]

Of course you need to do what is helping Mel.

But armed with the knowledge that there was enough evidence to suggest a warning by the FDA, your doctor should therefore be paying extra attention to monitoring cardio-vascular effects while Danny is on the Celebrex. Same as when someone is on meds that may impact liver function, the docs should stay on top of it by extra careful monitoring while the patient is on the med.

[MomWithOCDSon]

Here's one with OCD/ and ibuprofen.

 

Supporting this, a case report is presented of a subject with OCD who developed comorbid paresthesia, for whose latter condition a regimen of ibuprofen was instituted. Thirteen weeks thereafter subject's OCD symptomatology had declined by 40% (YBOC scale) from baseline. Inasmuch as ibuprofen and numerous other non-steroidal anti-inflammatory drugs (NSAIDS) block brain neuronal prostaglandin synthase (several also inhibiting phospholipases A(2)and C), thereby reducing catabolism of neuronal membrane arachidonic acid, the ibuprofen apparently increased the integrity of subject's neuronal membranes, as would likely also be the case with EFA dietary supplementation.

 

http://www.ncbi.nlm.nih.gov/pubmed/11339839

 

PS Can anyone find the full-text?

 

I haven't found the full text, unfortunately, but I'm fascinated by this research. I mean, it dates back to 2001 and basically aligns OCD with inflammation and, potentially, auto-immune disorders, as well! Where, oh where, are all our docs when it comes to this stuff?!?! You know how Vickie subscribes to "Google alerts," so she's frequently the first to pop in a link to new press regarding PANDAS? Well, don't you think the docs could be similarly "informed," set their "preferences" to inform them about new research, studies, etc. in their chosen fields?!?! It's mind-boggling.

 

Incidentally, I didn't know what "parasthesia" was, so I Wiki-ed it. Here's a section of their info that many of us here might relate to:

 

"Another cause of paresthesia, however, may be direct damage to the nerves themselves, i.e. neuropathy, which itself can stem from injury or infection such as frostbite or Lyme disease, or which may be indicative of a current neurological disorder. Chronic paresthesia can sometimes be symptomatic of serious conditions, such as a transient ischemic attack, motor neuron disease, or autoimmune disorders like multiple sclerosis or lupus erythematosus. The herpes zoster virus can attack nerves causing numbness instead of pain commonly associated with shingles. A diagnostic evaluation by a doctor is necessary to rule these out. Demyelination diseases may also cause cross-talk between adjacent axons and lead to parasthesia. During impulse conduction some aberrant current that escaped a demyelinated axon can circulate in the exterior and depolarize an adjacent demyelinated, hyperexcitable axon. This can generate impulses conducted in both directions along this axon since no part of the axon is in a refractory state. This becomes very serious in conditions such as multiple sclerosis and Guillain-Barre Syndrome."

 

Thanks for posting, EAMom!