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There are a few possibilities and others have mentioned some of them. Has he had a vaccine in the last few weeks or months? That triggers new or returning symptoms in some. Have you moved or changed schools? That could indicate something in the new environment, such as mold. Any recent dental work? That can be a trigger for some. I agree with HopeinHIM - if he hasn't been evaluated by an LLMD for Lyme, Bart, etc, this would be a good time. These infections deplete the immune system and can cause allergies, immune deficiency and autoimmunity.

My son has been on Zithromax for over a year (500mg 3x a week) and his Dr. wants him to be on it until he has and adult immune system. We have discovered that when he goes off the antibiotics, he starts to relapse.

Yes, we had severe OCD, then a couple of years of normalcy, and then an awful flare after some sickness.