Phasmid Posted June 10, 2010 Report Posted June 10, 2010 (edited) Volume 31, Issue 2, Pages 119-121 (August 2004) Muneaki Matsuo, MD*, Katsunori Tsuchiya, MD*, Yuhei Hamasaki, MD*, Harvey S. Singer, MD† Received 9 September 2003; accepted 17 December 2003. Abstract Group A β-hemolytic streptococcal infections have been reported to cause neuropsychiatric symptoms, such as chorea, tics, and obsessive-compulsive disorder, presumably through autoimmune damage to basal ganglia. Mycoplasma pneumoniae infections have also been reported to cause damage to the basal ganglia. Restless legs syndrome is a movement disorder with focal restlessness, an irresistible desire to move, and exacerbation by long periods of sitting or lying. We present three children with transient restless legs syndrome–like symptoms possibly associated with group A β-hemolytic streptococcal infection or Mycoplasma pneumoniae infection. One of three patients had persistently elevated enzyme-linked immunosorbent optical density values against human caudate and putamen. Edited June 10, 2010 by Phasmid
Fixit Posted June 10, 2010 Report Posted June 10, 2010 Volume 31, Issue 2, Pages 119-121 (August 2004) 11 of 22 ABSTRACT FULL TEXT FULL-TEXT PDF (43 KB) GET FULL TEXT ELSEWHERE CITATION ALERT CITED BY RELATED ARTICLES EXPORT CITATION EMAIL TO A COLLEAGUE RIGHTS/PERMISSIONS NEED REPRINTS? BOOKMARK ARTICLE <H1 class=ja50-ce-title>Restless legs syndrome: Association with streptococcal or mycoplasma infection</H1> Muneaki Matsuo, MD*, Katsunori Tsuchiya, MD*, Yuhei Hamasaki, MD*, Harvey S. Singer, MD† Received 9 September 2003; accepted 17 December 2003. Abstract Group A β-hemolytic streptococcal infections have been reported to cause neuropsychiatric symptoms, such as chorea, tics, and obsessive-compulsive disorder, presumably through autoimmune damage to basal ganglia. Mycoplasma pneumoniae infections have also been reported to cause damage to the basal ganglia. Restless legs syndrome is a movement disorder with focal restlessness, an irresistible desire to move, and exacerbation by long periods of sitting or lying. We present three children with transient restless legs syndrome–like symptoms possibly associated with group A β-hemolytic streptococcal infection or Mycoplasma pneumoniae infection. One of three patients had persistently elevated enzyme-linked immunosorbent optical density values against human caudate and putamen. THis episode from over a year ago started in his legs!!!!!! we have constant movements all over the body now!!!!!! THANK YOU!!!!! Again neg igm pos igg 637...now numbers look better but he doesnt'.... did i hear the myco p can hide in seperate organs or just the spine!!!!!
Phasmid Posted June 10, 2010 Author Report Posted June 10, 2010 Journal of Child Neurology... First published on March 19, 2010 Journal of Child Neurology 2010, doi:10.1177/0883073809355823 Transient Basal Ganglia and Thalamic Involvement Following Mycoplasma pneumoniae Infection Associated With Antiganglioside Antibodies Carlo Fusco, MD1*, Elena Bonini, PNP1, Giuliana Soncini, PNP1, Daniele Frattini, MD1, Simona Giovannini, MD2, and Elvio Della Giustina, MD1 1 Pediatric Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy 2 Pediatric Neurology Unit, Ospedale Maggiore, Bologna, Italy * To whom correspondence should be addressed. E-mail: Fusco.Carlo@asmn.re.it . Abstract A case of acute and reversible bilateral basal ganglia withthalami involvement associated with serological evidence ofMycoplasma pneumoniae infection is reported. Increased titersof immunoglobulin M antibodies against GM1 ganglioside componentswere found during an acute phase of neurological illness. Brainmagnetic resonance imaging (MRI) showed bilateral involvementof the basal ganglia and thalamus, which disappeared 1 monthlater. The child recovered fully after corticosteroid and immunoglobulintherapy, and antiganglioside antibodies returned to within thenormal range. The authors speculate on the diagnostic hypothesisregarding selective basal ganglia and thalamic involvement andthe relationship with anti-GM1 ganglioside immunoglobulin Mantibodies. Volume 31, Issue 2, Pages 119-121 (August 2004) 11 of 22 ABSTRACT FULL TEXT FULL-TEXT PDF (43 KB) GET FULL TEXT ELSEWHERE CITATION ALERT CITED BY RELATED ARTICLES EXPORT CITATION EMAIL TO A COLLEAGUE RIGHTS/PERMISSIONS NEED REPRINTS? BOOKMARK ARTICLE <H1 class=ja50-ce-title>Restless legs syndrome: Association with streptococcal or mycoplasma infection</H1> Muneaki Matsuo, MD*, Katsunori Tsuchiya, MD*, Yuhei Hamasaki, MD*, Harvey S. Singer, MD† Received 9 September 2003; accepted 17 December 2003. Abstract Group A β-hemolytic streptococcal infections have been reported to cause neuropsychiatric symptoms, such as chorea, tics, and obsessive-compulsive disorder, presumably through autoimmune damage to basal ganglia. Mycoplasma pneumoniae infections have also been reported to cause damage to the basal ganglia. Restless legs syndrome is a movement disorder with focal restlessness, an irresistible desire to move, and exacerbation by long periods of sitting or lying. We present three children with transient restless legs syndrome–like symptoms possibly associated with group A β-hemolytic streptococcal infection or Mycoplasma pneumoniae infection. One of three patients had persistently elevated enzyme-linked immunosorbent optical density values against human caudate and putamen.
Fixit Posted June 10, 2010 Report Posted June 10, 2010 Brainmagnetic resonance imaging (MRI) showed bilateral involvementof the basal ganglia and thalamus, which disappeared 1 monthlater. The child recovered fully after corticosteroid and immunoglobulintherapy, and antiganglioside antibodies returned to within thenormal range. not that it matters..are they saying the brain resolved on its own...but the child still had movements so they did cort and immun.... or as result of cort and immun..the chilld recovered in a month??
Phasmid Posted June 10, 2010 Author Report Posted June 10, 2010 (edited) I think it is saying that some resolution at one month, followed by full recovery after ivig and steroid so glad i decided to send CaM kinase test in... Edited June 10, 2010 by Phasmid
Fixit Posted June 10, 2010 Report Posted June 10, 2010 thanks for the info..and your understanding of it
bgbarnes Posted June 10, 2010 Report Posted June 10, 2010 Volume 31, Issue 2, Pages 119-121 (August 2004) Muneaki Matsuo, MD*, Katsunori Tsuchiya, MD*, Yuhei Hamasaki, MD*, Harvey S. Singer, MD† Received 9 September 2003; accepted 17 December 2003. Abstract Group A β-hemolytic streptococcal infections have been reported to cause neuropsychiatric symptoms, such as chorea, tics, and obsessive-compulsive disorder, presumably through autoimmune damage to basal ganglia. Mycoplasma pneumoniae infections have also been reported to cause damage to the basal ganglia. Restless legs syndrome is a movement disorder with focal restlessness, an irresistible desire to move, and exacerbation by long periods of sitting or lying. We present three children with transient restless legs syndrome–like symptoms possibly associated with group A β-hemolytic streptococcal infection or Mycoplasma pneumoniae infection. One of three patients had persistently elevated enzyme-linked immunosorbent optical density values against human caudate and putamen. Thank you guys for posting this- we have positive IGG myco in addition to high titers...I KNOW it is a big part of this!! Brandy
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