Nervous system dysfunction

[jewels]

Opinion statement There is an “emerging concept” that central nervous system dysfunction can be caused by an aberrant immune response triggered by exogenous antigens such as the food allergen gluten or streptococcal infection. The hypothesis of a gluten sensitive ataxia remains unproven, but is worthy of consideration. The data in support of this hypothesis require critical review before any treatment recommendations can be formulated. The idea that anti-gliadin antibody seropositivity per se justifies the term “gluten sensitivity” is important because it offers potential therapeutic possibilities, including simple exclusion diets, for patients with antigliadin antibody-associated ataxia. Post-streptococcal basal ganglia dysfunction has various manifestations, all of which fall into a relatively well-defined symptom complex or syndrome. Anti-basal ganglia antibodies that are associated with serologic evidence of recent streptococcal infection are a potential diagnostic marker for this group of disorders, which includes Sydenham’s chorea (SC) as the prototype. More recently subjects with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, Tourette’s syndrome, obsessive-compulsive disorder and other movement disorders have been described in association with anti-basal ganglia antibodies. The apparent overlap between the clinical phenotype of SC, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, Tourette’s syndrome, and obsessive-compulsive disorder suggests that they may represent one disease entity. The current working hypothesis is that antibodies induced in response to streptococcal infection cross-react with antigenic determinants in the basal ganglia resulting in basal ganglia dysfunction. Although the experimental evidence is incomplete, there is sufficient evidence to support immune-mediated basal ganglia dysfunction as an emerging clinical entity. This has important implications for the diagnosis and treatment of subjects with these disorders. The latter includes the judicious use of anti-biotic prophylaxis and immunomodulatory therapies. Apart from the diagnosis and management of SC, no consensus exists regarding the diagnosis and management of the other clinical entities within this group of disorders

 

This is an abstract from Drs who have carried out trials on PANDAS. It was published in 2007, but I can see a connection in our case to the gluten sensitive ataxia. before we removed gluten from dds diet we had lost most of her eye contact, she spinned around all the time (even when walking) and showed other ASD symptoms - this was with our first PANDAS onset.

 

It was a long slow process of allergy testing and lifestyle cleanups, but we can say in our case this helped enormously. It took over two months of being GF before we gained back all her eye contact etc. I would recommend allergy testing for all PANDAS children. Even if a test comes back negative but you see a connection then a rotation diet is a good idea, as we also noticed neg. on test results but reactions when reintroduced. The reactions were mainly gut issues, red ears and hyperness.

 

The antigenic determinants cross-reacting with strep antibodies is interesting but I need the brains on this site to help me understand that one!

 

Jules

[ShannonOtown]

Interesting connection. I know a lot of parents on the TS/Tic forum do food IGE allergy test... I'm just did one for my son last week (out of pocket home kit) and I'm waiting for the results today. I will definitely look for a Gluten sensitivity number and reply back if it's positive/high results.

[Fixit]

Opinion statement There is an “emerging concept” that central nervous system dysfunction can be caused by an aberrant immune response triggered by exogenous antigens such as the food allergen gluten or streptococcal infection. The hypothesis of a gluten sensitive ataxia remains unproven, but is worthy of consideration. The data in support of this hypothesis require critical review before any treatment recommendations can be formulated. The idea that anti-gliadin antibody seropositivity per se justifies the term “gluten sensitivity” is important because it offers potential therapeutic possibilities, including simple exclusion diets, for patients with antigliadin antibody-associated ataxia. Post-streptococcal basal ganglia dysfunction has various manifestations, all of which fall into a relatively well-defined symptom complex or syndrome. Anti-basal ganglia antibodies that are associated with serologic evidence of recent streptococcal infection are a potential diagnostic marker for this group of disorders, which includes Sydenham’s chorea (SC) as the prototype. More recently subjects with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, Tourette’s syndrome, obsessive-compulsive disorder and other movement disorders have been described in association with anti-basal ganglia antibodies. The apparent overlap between the clinical phenotype of SC, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, Tourette’s syndrome, and obsessive-compulsive disorder suggests that they may represent one disease entity. The current working hypothesis is that antibodies induced in response to streptococcal infection cross-react with antigenic determinants in the basal ganglia resulting in basal ganglia dysfunction. Although the experimental evidence is incomplete, there is sufficient evidence to support immune-mediated basal ganglia dysfunction as an emerging clinical entity. This has important implications for the diagnosis and treatment of subjects with these disorders. The latter includes the judicious use of anti-biotic prophylaxis and immunomodulatory therapies. Apart from the diagnosis and management of SC, no consensus exists regarding the diagnosis and management of the other clinical entities within this group of disorders

 

This is an abstract from Drs who have carried out trials on PANDAS. It was published in 2007, but I can see a connection in our case to the gluten sensitive ataxia. before we removed gluten from dds diet we had lost most of her eye contact, she spinned around all the time (even when walking) and showed other ASD symptoms - this was with our first PANDAS onset.

 

It was a long slow process of allergy testing and lifestyle cleanups, but we can say in our case this helped enormously. It took over two months of being GF before we gained back all her eye contact etc. I would recommend allergy testing for all PANDAS children. Even if a test comes back negative but you see a connection then a rotation diet is a good idea, as we also noticed neg. on test results but reactions when reintroduced. The reactions were mainly gut issues, red ears and hyperness.

 

The antigenic determinants cross-reacting with strep antibodies is interesting but I need the brains on this site to help me understand that one!

 

Jules

 

do you have a link to the above...i would love to take this to my pediatrician......(it wasn't just your opinion right?)

[smartyjones]

... I'm just did one for my son last week (out of pocket home kit)

 

 

can you tell me what that home kit is?

thanks.

[ShannonOtown]

... I'm just did one for my son last week (out of pocket home kit)

 

 

can you tell me what that home kit is?

thanks.

 

 

I ordered the Basic Act/Elisa Food Panel IGE test for $350 (ouch) from directlabs.com

 

There are other test recommended on the forum from Great Plains Laboratory, they seemed more expensive. Look for a test that includes dyes, chemicals, molds, etc so your results give a broad view of sensitivities.

[jewels]

Hi Fixit,

 

I have enclosed the link It was written by our MAIN PANDAS drs, They have published lots of interesting papers.

 

 

http://www.springerlink.com/content/a7t376g55h173975

 

 

Jules

[jewels]

Hi Fixit,

 

I have enclosed the link It was written by our MAIN PANDAS drs, They have published lots of interesting papers.

 

 

http://www.springerlink.com/content/a7t376g55h173975

 

 

Jules

I've just re-read my post! Main ones - means one of the very few in the UK,

 

Jules

[Suzan]

Based on our experiences, I do believe there is a gluten connection as well. I would be intereseted in learning more.

 

Susan