Titer results from Dr. Cunningham

[Debbie1]

I just received titer results from Dr. Cunningham's lab. Can anyone help me understand what they mean?

 

Thanks,

Debbie

 

Results:

 

Anti-Lysoganglioside 2 hours

patient 320

positive control >1280

negative control 160

normal range 80-320

normal mean 147

 

Anti-Tubulin 2 hours

patient 1000

positive control 16000

negative control 250

normal range 250-1000

normal mean 609

 

Anti-Dopamine 1 2 hours

patient 4000

positive control 8000

negative control 1000

normal range 500-2000

normal mean 1056

 

Anti-Dopamine 2 2 hours

patient 8000

positive control 16000

negative control 2000

normal range 2000-16000

normal mean 6000

[dee45]

what was your cam kinase level?

 

Deanna

[Debbie1]

what was your cam kinase level?

 

Deanna

 

Cam kinase was 137 (I received that result several weeks ago)

[Buster]

The short answer is they don't really mean anything at this time. The CaM Kinase II values have some comparatives for PANDAS and non-PANDAS kids and SC and non-SC kids, but the others are antibodies they are checking and at this point it's not known what these values actually mean or whether they are correlated with any symptoms. Sorry, that's the frustration with this stage of research trials. Usually, they wouldn't release the measures to us until the end of the study, but I'm glad for any info :-)

 

With respect to the results, the numbers are saying that when they checked your child's draw, they had slightly elevated anti-tubulin (but only one dilution away) and slightly elevated anti-d1 (i.e., antibodies that would bond with dopamine receptor 1 if given the chance). Again both are only slightly elevated versus the other samples she's seen. They don't yet know whether certain medications affect these values or not which is why they've been asking for more history from parents.

 

I'd recommend not worrying too much about these values. The CaM Kinase II seems to be correlated (especially when > 170) but again, it's still early to know how to read the results.

 

Buster

 

I just received titer results from Dr. Cunningham's lab. Can anyone help me understand what they mean?

[ajcire]

I just received these results a couple of minutes ago too. It's so hard to have numbers and want them to tell something but to know they don't tell a story yet especially when some of those results that have no meaning yet are way higher than the range given.

 

 

 

 

 

The short answer is they don't really mean anything at this time. The CaM Kinase II values have some comparatives for PANDAS and non-PANDAS kids and SC and non-SC kids, but the others are antibodies they are checking and at this point it's not known what these values actually mean or whether they are correlated with any symptoms. Sorry, that's the frustration with this stage of research trials. Usually, they wouldn't release the measures to us until the end of the study, but I'm glad for any info :-)

 

With respect to the results, the numbers are saying that when they checked your child's draw, they had slightly elevated anti-tubulin (but only one dilution away) and slightly elevated anti-d1 (i.e., antibodies that would bond with dopamine receptor 1 if given the chance). Again both are only slightly elevated versus the other samples she's seen. They don't yet know whether certain medications affect these values or not which is why they've been asking for more history from parents.

 

I'd recommend not worrying too much about these values. The CaM Kinase II seems to be correlated (especially when > 170) but again, it's still early to know how to read the results.

 

Buster

 

I just received titer results from Dr. Cunningham's lab. Can anyone help me understand what they mean?

[Debbie1]

Thanks Buster.

 

The short answer is they don't really mean anything at this time. The CaM Kinase II values have some comparatives for PANDAS and non-PANDAS kids and SC and non-SC kids, but the others are antibodies they are checking and at this point it's not known what these values actually mean or whether they are correlated with any symptoms. Sorry, that's the frustration with this stage of research trials. Usually, they wouldn't release the measures to us until the end of the study, but I'm glad for any info :-)

 

With respect to the results, the numbers are saying that when they checked your child's draw, they had slightly elevated anti-tubulin (but only one dilution away) and slightly elevated anti-d1 (i.e., antibodies that would bond with dopamine receptor 1 if given the chance). Again both are only slightly elevated versus the other samples she's seen. They don't yet know whether certain medications affect these values or not which is why they've been asking for more history from parents.

 

I'd recommend not worrying too much about these values. The CaM Kinase II seems to be correlated (especially when > 170) but again, it's still early to know how to read the results.