Leckman reduced IgA

[kim]

Was this one posted already?

 

http://www.journals.elsevierhealth.com/per...tent/0900729abs

 

Children with Tourette's Syndrome May Suffer IgA Dysgammaglobulinemia: Preliminary Report

[Suzan]

Was this one posted already?

 

http://www.journals.elsevierhealth.com/per...tent/0900729abs

 

Children with Tourette's Syndrome May Suffer IgA Dysgammaglobulinemia: Preliminary Report

 

I am interested in this because my kids both have very low normal IgA. I tried to search on IgA dysgammaglobulinemia but the stuff I saw was not getting me what I was wanting to find out which is how low is low? Does IgA dysgammaglobulinemia mean an official deficency?

 

Susan

[kim]

Susan,

 

Do you just need the range?

 

These are two that I found. Just search "normal values IgA" you'll get lots of stuff.

 

IgA: 80-350 mg/dl

78-367

 

This is one

 

http://www.lymphomation.org/tests-immunoglobulins.htm#IgA

[EAMom]

Thanks for posting Kim...very interesting.

[Suzan]

Susan,

 

Do you just need the range?

 

These are two that I found. Just search "normal values IgA" you'll get lots of stuff.

 

IgA: 80-350 mg/dl

78-367

 

This is one

 

http://www.lymphomation.org/tests-immunoglobulins.htm#IgA

 

I guess I was hoping to find out if they mean low IgA like way below range or if they were implying anything else.... (for my dd's age the low range is 34 and her IgA was 37) Our immunologist is not concerned about her low normal result. Thanks!

[kim]

Susan,

 

I'm sorry. I should have known that you were perfectly capable of finding those ranges.

 

I ran across an interesting article last night and thought of you. I don't know if theres any of the specific info that your looking for here, but thought others might want to look at this too. The two clickable links at the bottom titled "Specific Diseases In Which Immunodeficiency Is Common and Importance of Zinc To The Immune System," have some good tid bits too. We have never used anything but vitamins and supplements here, and that remains my focus. If something like IVIG were ever to become an necessity, well all of that is something that I like to get some education on too, but much of my interest is in specific targeted supplementation with out doing a bunch of testing except when it's really necessary. Anyway.....

 

I'm leaving an excerpt of who Dr. Shaw is, for those not familiar with Great Plains labs. When reading net info. I like background on who wrote what I'm reading.

 

excerpt

http://www.greatplainslaboratory.com/home/eng/founder.asp

 

William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., Dr. Shaw worked for the Centers for Disease Control and Prevention (CDC), Children’s Mercy Hospital, University of Missouri at Kansas City School of Medicine, and Smith Kline Laboratories. He is the author of Biological Treatments for Autism and PDD, originally published in 1998 and Autism: Beyond the Basics, published in 2009. He is also a frequent speaker at conferences worldwide.

 

 

http://www.parentsofallergicchildren.org/immune_system.htm

 

The Immune System

 

by Dr. Shaw

 

excerpt

http://www.parentsofallergicchildren.org/i...cy_diseases.htm

 

In Gupta's study, 20% of the children with autism had a deficiency of IgA and 8% lacked it completely. Reed Warren and his colleagues also found that 20% of individuals with autism had low serum IgA compared with none of the normal individuals used as controls.

[peglem]

Susan,

 

Do you just need the range?

 

These are two that I found. Just search "normal values IgA" you'll get lots of stuff.

 

IgA: 80-350 mg/dl

78-367

 

This is one

 

http://www.lymphomation.org/tests-immunoglobulins.htm#IgA

 

I guess I was hoping to find out if they mean low IgA like way below range or if they were implying anything else.... (for my dd's age the low range is 34 and her IgA was 37) Our immunologist is not concerned about her low normal result. Thanks!

My daughter's IgA is significantly below normal range and her immunologist is not concerned. She also is below range in IgG4 subclass, which he also doesn't see as constituting a deficiency. When I look up info on those 2, I only see that they think deficiency makes one more prone to autoimmune diseases-particularly with IgA. Over and over I read that at this time, they are uncertain of the implications of IgG4 deficiency. Her other IgG subclasses are in the low normal range, and total IgG is below normal range....

[kim]

Peglem,

 

This "galactose deficiency" has got me curious. You see this refered to with rheumatoid arthritis and glomerulonephritis too. I'm wondering if this is more a factor than the levels found? Apparently, galactose deficiency is known to precipitate autoimmunity?

 

 

http://jdr.sagepub.com/cgi/reprint/84/10/897.pdf

 

Galactose-deficient IgG4 may, in

tissues, activate complement, with all the resultant

inflammatory consequences. Thus, the anti-inflammatory

properties of IgA and IgG4, manifested by their ability to

interfere with IgG1-, IgG2-, and IgG3-mediated complement

activation, are lost due to their altered glycans (Russell et al.,

1989, 1997).

In autoimmune diseases, such as rheumatoid arthritis, tissue

components and cartilage collagen Type II, in particular, are

the autoantigens recognized by galactose-deficient IgG

molecules (Rademacher et al., 1994). We have demonstrated,

in our earlier studies, that in periodontal disease, collagens

Type I and III are recognized by locally produced IgG

antibodies (Hirsch et al., 1988). Therefore, in addition to

antigens derived from bacteria associated with periodontal

disease, tissue autoantigens may also be targets of IgG

antibodies that, in turn, activate, in the form of immune

complexes, complement cascade with all its inflammatory

sequelae and subsequent tissue damage.

Glycosylation of immunoglobulins is mediated by a large

[Suzan]

My daughter's IgA is significantly below normal range and her immunologist is not concerned. She also is below range in IgG4 subclass, which he also doesn't see as constituting a deficiency. When I look up info on those 2, I only see that they think deficiency makes one more prone to autoimmune diseases-particularly with IgA. Over and over I read that at this time, they are uncertain of the implications of IgG4 deficiency. Her other IgG subclasses are in the low normal range, and total IgG is below normal range....

 

peglem, I imagine you have looked at this already, but I thought I would pass it along...

 

"Some people with low serum IgA have a clinical course very similar to people with Common Variable Immunodeficiency."

 

http://www.immunedisease.com/patients-and-...deficiency.html

[peglem]

Okay, Kim, I tried to read that in its entirety...and understand it. Here's what I got that I hope is right: IgG needs N acetylglucosamine in order to attach to Fc receptors. (I have no idea what those are)

 

Also, IgA and IgG4 are anti-inflammatories.

 

That's about all. I'll have to go back and read again when my brain is less mush.

[melanie]

My daughter's IgA is significantly below normal range and her immunologist is not concerned. She also is below range in IgG4 subclass, which he also doesn't see as constituting a deficiency. When I look up info on those 2, I only see that they think deficiency makes one more prone to autoimmune diseases-particularly with IgA. Over and over I read that at this time, they are uncertain of the implications of IgG4 deficiency. Her other IgG subclasses are in the low normal range, and total IgG is below normal range....

 

peglem, I imagine you have looked at this already, but I thought I would pass it along...

 

"Some people with low serum IgA have a clinical course very similar to people with Common Variable Immunodeficiency."

 

http://www.immunedisease.com/patients-and-...deficiency.html

 

 

Oh I think this is what triffiletti tested danny for He said his ig?was low and if its low maybe he could get ivig treatments but wait if he is low and now hes sick wouldnt that make the igm gigh making low levels not sow low get it? Does that make sense?

Melanie

[faith]

Oh I think this is what triffiletti tested danny for He said his ig?was low and if its low maybe he could get ivig treatments but wait if he is low and now hes sick wouldnt that make the igm gigh making low levels not sow low get it? Does that make sense?

Melanie

 

no, could you say that again please? What Ig... did Dr. Trifilletti test for ? he took blood at your visit? He knows immuno testing? I'd like to know as we have an appt. with him too.

 

Thanks

Faith

[kim]

Here's what I got that I hope is right: IgG needs N acetylglucosamine in order to attach to Fc receptors. (I have no idea what those are)

 

Also, IgA and IgG4 are anti-inflammatories.

 

Peglem,

 

Believe me, if you are wrong I won't know it. I don't understand it either. I was surprized to see you mention NAC. I forgot that was even in the article, but that's probably what lead me to this particular study in the first place. Back when we were discussing Guillain-Barré, I read an abstract that said that normally ganglioside was resistant to the antibody that they suspected caused the cross reaction. Then, it said that they bypassed immunolgical tolerance by creating a knock out mouse. What they blocked was 1,4-N-acetylgalactosaminyl transferase. When they did that, high antibody was then formed to the bacteria that they were looking at. When I ran into "galactose deficient" again, I went snooping around and found it mentioned again with RA and glomerulonephritis.

 

Ok, in my notes I see where I saved

 

PVL detects galactose-deficient N-linked glycans through their binding

to terminal N-acetylglucosamine (Tsuchiya et al., 1993). IgG (or

serum diluted 1:1000)

 

So if galactose binds NAC, and galactose is deficient (what makes it deficient in the first place?) then NAC is exposed?

 

Here is another oldere study that refers to RA.

 

http://www.springerlink.com/content/g7757312747704n1/

 

Received: 6 May 1994 Accepted: 24 May 1994

 

Abstract It is now well established that rheumatoid arthritis patients have reduced levels of galactose on their immunoglobulin G (IgG) molecules compared with normal individuals.

[kim]

This is from Buster's recent "update" thread on PANDAS....the plot thickens

 

http://www.sciencemag.org/cgi/content/abstract/320/5874/373 2008

 

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

Robert M. Anthony,1 Falk Nimmerjahn,1,4 David J. Ashline,2 Vernon N. Reinhold,2 James C. Paulson,3 Jeffrey V. Ravetch1*

[kim]

expanded info from abstract above

 

excerpt

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409116/

 

The complex, bi-antennary N-linked glycan found at Asn 297 of the IgG Fc consists of a heptasaccharide which can be variably modified by the addition of fucose or GlcNAc to the Man3GlcNAc2 core, and galactose and sialic acid to the outer arms (Figure 1A)(1). The fully processed N-linked glycan is present on 2–4% of the total IgG in IVIG(2). The anti-inflammatory activity of IVIG has been demonstrated in a variety of animal models of autoimmunity, including autoantibody induced thrombocytopenia(3), serum transfer arthritis(4) and nephrotoxic nephritis(5) and is a property of the Fc fragment and its associated glycan(2, 3, 6). Removal of the terminal sialic acid of IVIG or its papain-derived Fc fragment abrogates the anti-inflammatory activity in these animal models. Conversely, enrichment of the sialylated fraction of IVIG enhances this activity(2).

 

 

Fc=Fragment crystallizable

 

http://en.wikipedia.org/wiki/Fc_fragment

 

The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. In IgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2-4) in each polypeptide chain.[1]