Gangliosides/diet

[kim]

Pretty interesting! Just found this this morning. At a glance "Lorenzo's oil" story comes to mind.

 

http://journals.lww.com/shockjournal/Fullt...mmatory.18.aspx

 

Dietary Ganglioside Inhibits Acute Inflammatory Signals in Intestinal Mucosa and Blood Induced By Systemic Inflammation of Escherichia Coli Lipopolysaccharide

[bronxmom2]

I read the abstract... but do you know any examples of dietary gangliosides?

[kim]

bronksmom,

 

There is So much going on in this house today, I can't concentrate, but "Oh my goodness", it looks like they are looking at METHIONINE

 

Under materials and methods

 

The fat was a blend of triglycerides, which reflected the fat composition of an existing infant formula (20). The composition of the basal diets fed has been previously reported (20).

 

 

look at reference #20

 

http://www.ncbi.nlm.nih.gov/pubmed/7189777

 

Effects of methionine supplementation on the incidence of dietary fat induced myocardial lesions in the rat.

[bronxmom2]

Thanks. This is from wikipedia entry on methionine:

 

High levels of methionine can be found in sesame seeds, Brazil nuts, fish, meats and some other plant seeds. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine.

 

If it's like infant formula I wonder if there's a lot of it in breast milk. I breastfed my PANDAS son for 3.5 years, and now that I think of it, 3.5 is exactly when the PANDAS started.

[kim]

Remember the study recently about N acetyl cysteine reducing the incidence of OCD, in what 60%? If you go back and look at the relationship of cysteine/methionine, the CBS mutation, MTHFR and others, well some things are making a little more sense!

 

Very interesting about the length of time you nursed!

 

Also, the "heart thread" there is some info there about cardiac changes when methionine is oxidized by elevated CamKin and a study about BEETS, Cabbage, and Garlic (Msra) reversing the effect! So much for working on halloween costumes today!

[kim]

Furthermore, we demonstrate that one way to enhance the MSRA antioxidant system is dietary supplementation withS-methyl-L-cysteine (SMLC), found abundantly in garlic, cabbage, and turnips.

 

From this thread

 

http://www.latitudes.org/forums/index.php?...l=Cam+Kinase+II

[Buster]

High levels of methionine can be found in sesame seeds, Brazil nuts, fish, meats and some other plant seeds. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine.

 

If it's like infant formula I wonder if there's a lot of it in breast milk. I breastfed my PANDAS son for 3.5 years, and now that I think of it, 3.5 is exactly when the PANDAS started.

 

Now that's a direction I never thought to pursue... masked/suppressed by breast milk ... I wonder if there's anything to that... really interesting thought.

[kim]

buster are you referring to the "unmasking" by the antibody or the composition of the ganglioside being vulnerable to the antibody due to prior composition?

[Buster]

buster are you referring to the "unmasking" by the antibody or the composition of the ganglioside being vulnerable to the antibody due to prior composition?

 

I was more commenting that you were pursuing a direction I hadn't paid any attention to (i.e., the impact of breast milk on immune response).

 

I was following the chain: "A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation." http://www.ncbi.nlm.nih.gov/pmc/articles/P...69/?tool=pubmed

 

That then took me over to the article "The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload" http://www.pnas.org/content/106/7/2342.full

 

I'm now going back to the papers you referenced. No idea if this will lead to something, but it was an unusual direction.

 

Thanks,

 

Buster

[bronxmom2]

Remember the study recently about N acetyl cysteine reducing the incidence of OCD, in what 60%? If you go back and look at the relationship of cysteine/methionine, the CBS mutation, MTHFR and others, well some things are making a little more sense!

 

Very interesting about the length of time you nursed!

 

Also, the "heart thread" there is some info there about cardiac changes when methionine is oxidized by elevated CamKin and a study about BEETS, Cabbage, and Garlic (Msra) reversing the effect! So much for working on halloween costumes today!

 

Believe me, I got a LOT of slack for nursing him as long as I did, maybe my body knew somehow that something was amiss.

 

I do remember the N-Acetyl Glucosamine discussion, and I am planning to buy some (I mentioned this in my post-PEX plan), because my understanding (per Buster's explanation) is that IVIG does something to regulate the T cells, but PEX does not.

 

Though I don't know if this is a good time to experiment...

 

I am still nursing my 18mo, now I am tempted to pump a little extra and sneak it in my PANDAS son's cereal bowl.