mitochondrial dysfunction

[kim]

Copy of a post from PANDAS forum....

 

Reading thru the PANDAS/PITANDS thread, I thought some here might be interested in reading this

 

http://www.huffingtonpost.com/david-kirby/...omment_12213955

 

The Next Big Autism Bomb: Are 1 in 50 Kids Potentially At Risk?

 

Apparently, in only two of the 30 cases, or 6%, could the regression be traced directly and temporally to immunizations, and one of them was Hannah Poling. In the other cases, there was reportedly some type of documented, fever-inducing viral infection that occurred within seven days of the onset of brain injury symptoms.

and

 

STEP TWO: Child develops mild, usually asymptomatic mitochondrial dysfunction (though I wonder if the ear infections and eczema so common in these cases might also be symptoms of mito problems).

 

TRIGGER TWO: Child, now with an underlying mitochondrial dysfunction, suffers over-stimulation of the immune system beyond the capacity of his or her metabolic reserves. This stress is either via a viral febrile infection, or from multiple vaccinations, as in the Poling case. This trigger results in:

 

STEP THREE: Acute illness, seizures, encephalopathy, developmental regression, autism.

 

Such a scenario might help explain why autism has increased right along with the addition of more vaccines to the national schedule.

 

And it might help explain why autism rates are not plummeting now that thimerosal levels have been significantly reduced in most childhood vaccines.

 

It's possible that exposures from the flu shot, and residual mercury left over in other vaccines -- perhaps in synergistic effect with aluminum used as an "adjuvant" to boost the immune response - might "contribute to the toxic mix that causes childhood mitochondrial dysfunction in the first place," one of the doctors said.

 

But like many hypotheses, this one has competition. Some researchers believe that the modern American diet is largely to blame for an increase in the number of children whose underlying mitochondrial dysfunction is "triggered" into autism by febrile infections.

 

The answer, they hypothesize, is corn.

 

Another mito article

 

http://www.medscape.com/viewarticle/573004

 

Study subjects were children aged 2 to 16 years who had a confirmed diagnosis of ASD and were referred for investigation of possible mitochondrial dysfunction due to the presence of markers for mitochondrial dysfunction, including increased lactate, pyruvate, and/or alanine.

 

Significant Numbers of Affected Individuals?

 

According to Dr. Shoffner, previous recent research has reported that up to 20% of children with autism have hyperlactacidemia and increased ratios of lactate/pyruvate.

[Caryn]

Corn, huh?

Wow.

[Chemar]

thanks Kim

 

I found that article fascinating when I first read it.

http://www.latitudes.org/forums/index.php?showtopic=3254

 

and yup re the corn Caryn