Cheri

[kim]

Cheri,

 

I have had a bottle of SamE sitting on my cupboard for a couple of months. I have no doubt about it's ability to help. The possible problem I see, is where eleveated levels of homocysteine come in. You could get the benefits because you are supplementing something that is lacking at the top, but have an underlying problem worsening that wouldn't be apparent. I think a simple blood test to check homosysteine levels would be all that might be necessary.

 

 

 

Cheri,

 

I forgot to include the links, Sorry! I'm posting in the middle of "multitasking" too

 

http://www.molvis.org/molvis/v14/a79/

 

C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma

 

The MTHFR C677T polymorphism was found to be associated with PCAG but not POAG in patients of Pakistani origin.

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1248649...Pubmed_RVDocSum

 

Bleich S, Jünemann A, von Ahsen N, Lausen B, Ritter K, Beck G, Naumann GO, Kornhuber J.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University, Schwabachanlage 6-10, D-91054 Erlangen-Nuremberg, Federal Republic of Germany. stefan.bleich@psych.imed.uni-erlangen.de

 

Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.

[Chemar]

hubby's mom had glaucoma and never ever took methionine

hubby is suspected glaucoma but cant complete the testing as it seriously wonked him out for days and totally diorientated him

 

I dont know about hubby or son's homocystine Kim, and at this point my son will NOT have any blood tests done as he is in OCD re needles/metals

 

I am still not fully understanding what you suggest the solution would be?

[CSP]

Kim,

 

Just wanted to send you out a huge thank you for all you do for us. And please give your family a big cyber hug and thank you for all the time they give you up for us.

 

That is so little a thank you for as much as I really wanted to say.

 

God Bless,

C.P.

[kim]

Oh CP you totally made me cry. Thank you too! I know how I must frustrate people, but honestly I'm doing the best I can. I need a signature line that says something like "How can I explain to others concepts that I don't fully understand"

 

Hugs to you too. If there is anything that I can help anyone here with, even at the risk of making a complete fool of myself, well, I guess i'll risk it.

 

Cheri,

 

I understand about your son not wanting blood work. I wonder if a urine test would work? Your son appears to be doing so well, it seems obvious that whatever you're doing is working well.

 

Supplementing methionine, wouldn't have anything to do with the interplay of the genetics that may be involved here. Let's say that the MTHFR mutation is one of the important mutations involved in this syndrome. Folic acid and B12 are important in getting this pathway to function right, if you have it. I'll try to find you a good link. IF you carry this mutation, you don't have what's needed to get to methionine and utimately to glutathione (major antioxidant). You can supplement methionine and get glutathione production increase, but you may also have homocysteine levels that are rising, if the form of B12 isn't being utilized correctly or not at all, and your folate, folanic acid (may be necessary instead of folate...i never got that straight) isn't where it should be. I'm going to go back and check this info. These mutations, CBS and MTHFR (there are others...COMP is one, which is a defect in sythesizing neurotransmittlers but having that mutation would just be too easy wouldn't it!) are part of the Yasko genetic testing. Other DAN's are testing these too. Sunshine's son who has the same type of bony tumor that my son has, showed a CBS hetro mutation (one copy that's not working) I believe these two mutations have quite a bit in common, with problems that result from different origins.

 

If your husbands mom had glaucoma it may just be an indication of part of the genetics involved, again, supplementing methionine might be beneficial in one way, but harmful in another. That's what you would want to watch out for. Does that help? If not, ask anything.

 

I might edit, if I find where I explained something wrong here. As always, this is only for discussion purposes! I'm not capable of getting all of this right, only giving others a place to look for there own answers.

 

I'm really starting to wonder how much mom AND dad contribute to all of this. It may appear to be so clear cut, but the more I learn, the more I wonder, in our case at least.

[Chemar]

(((((((((Kim)))))))) thanks so much for the summary in language I could understand LOL one of the reasons I quit my pre-kids career was I am chemically/mathematically challenged and I can research endlessly on some things but totally blank out on others....so you have no idea how I respect your ability to dig into the biochemistry and the genetics

 

I hope I didnt sound unthankful for your looking into this so deeply, and drawing it to my attention. I had to rush out to a meeting and was doing my quick morning fly-by here

 

I will dig out old blood tests on hubby and son and see if any homocysteine or glutathion stuff shows.

The 500mg methionine per day was rx for my son by the integrative doc back in 2002 when he had waxing of anxiety -OCD quite seriously. He was already on the 50 mg 5HTP each evening and taking the inositol & st John's wort mornings. The methionine had an instant calming effect on him. The form he takes now is incorporated in his protein shake mix and says seleno-methionine. son has not used samE

 

hubby only started using the samE about a month ago on advisement of an ortho to help with the back pain and found it really helped his mood/OCD

 

both already take methyl-cobalamin form of B12, and I know there is folic acid in the shake son uses

 

will post back if I learn anything more

blessings

[kim]

Cheri,

 

You didn't sound one bit unthankful. THANK YOU for hanging in here with me on this!

 

I want you to scan this study. It just seems I'm seeing a reoccuring theme here. Something to do with clotting abilities and how the Gags are sulfated. Remember when we were talking about connective tissue and conditions your son was born with?

 

http://www.ncbi.nlm.nih.gov/pubmed/8095623

 

We have studied the distribution and nature of sulphated glycosaminoglycans (GAGs) within normal and inflamed intestine. There is increasing evidence that these negatively charged polysaccharides, which both regulate the ability of albumin to leave the vasculature and inhibit thrombosis, may be affected by inflammatory cells and their products. We obtained samples of freshly resected intestinal tissue from eight controls, eleven patients with Crohn's disease, and six with ulcerative colitis. Sulphated GAGs were detected by means of a gold-conjugated poly-L-lysine probe, and the tissue density of anionic sites was assessed semiquantitatively by means of a Lennox graticule. In normal intestine there was staining in the vascular endothelium and the subepithelial basal lamina and throughout the extracellular matrix of the lamina propria and submucosa. Tissue from the patients with inflammatory bowel disease showed inflammation macroscopically and on histology. There were profound abnormalities of extracellular matrix GAGs, limited to the mucosa in ulcerative colitis and greatest in the submucosa in Crohn's disease. There was also substantial loss of GAGs from the subepithelial basal lamina in both disorders and from the vascular endothelium in submucosa in Crohn's disease. The extent of local GAG disruption was associated with the distribution of macrophages immunoreactive for tumour necrosis factor alpha and the activation marker RM 3/1. We suggest that inflammatory disruption of vascular and connective tissue GAGs may be an important pathogenetic mechanism, contributing to the leakage of protein and fluid, thrombosis, and tissue remodelling seen in inflammatory bowel disease.

 

 

These were the two things that really grab my attention but I'm wondering if it's the other way around, the GAGs have a problem FIRST only in a different area...bolding mine

 

 

We have studied the distribution and nature of sulphated glycosaminoglycans (GAGs) within normal and inflamed intestine. There is increasing evidence that these negatively charged polysaccharides, which both regulate the ability of albumin to leave the vasculature and inhibit thrombosis, may be affected by inflammatory cells and their products.

 

and

 

 

We suggest that inflammatory disruption of vascular and connective tissue GAGs may be an important pathogenetic mechanism, contributing to the leakage of protein and fluid, thrombosis, and tissue remodelling seen in inflammatory bowel disease

[kim]

Cheri,

 

Since I had posted this article a few times already I was going to see if I could find anything new, but I can't find anything that explains MTHFR or CBS mutations any better than this. I know you haven't had time to read every post here, so here it is again. I sure hope things are looking up for your husband.

 

http://www.med.uiuc.edu/hematology/PtHomocysteinemia.htm