Supplement substitute for IVIG

[Kathy4Him]

I was cleaning out my pantry today and found this powder: G I Protect, DS Dr. Stephanie Cave gave us a couple of years ago that he quit taking. It was supposed to help malabsorption - leaky gut.

 

My son has, so far, refused IVIG because he does not want donor antibodies.

 

I began reading the label and this is what it says...GI Protect features XYMOGEN 's exclusive IGg 2000 dfwith the added benefit of the amino acid L Glutamine. IGg 2000 represents a breakthrough in immunoglobin supplementation.It is a highly concentrated non dairy source of serum derived immunoglobin antibodies and immunoproteins.

 

I am in a hurry but will post a link to their site maybe some of you experienced parents can ck it and let me know what you think. ?I am dropping my container of at Drs today (rheumatologist, who is treating him for pandas) to see what he thinks.

 

Thanks!!!! Kathy

[Missmom]

Interesting, is that something that was prescribed for him a few years ago, or did you get it over the counter. Would be curious what other types of diseases/conditions this product is being used for. Just going by the name it would seem to be some type of probiotic supplement.

[Kathy4Him]

Interesting, is that something that was prescribed for him a few years ago, or did you get it over the counter. Would be curious what other types of diseases/conditions this product is being used for. Just going by the name it would seem to be some type of probiotic supplement.

 

 

It was prescribed by Dr. Stephanie Cave, MD for leaky gut/malasorption. We buy it at her office. She runs lots of the tests described on this forum, her love is helping autistic kids but helps very ill patients from all over the world.

She is big on supplements for healing. It is not considered a probiotic.

I think she gives it mainly for gut issues.

[JAG10]

My dd13 has been taking IgG2000 for about a month suggested by Dr. O'Hara as a step-down from IVIG. Her last IVIG was in Aug 2012, with one 16 weeks before that and 8 to 9 week intervals before that. So far, she is holding steady with her progress. She takes 2 capsules/day in the morning. We haven't had her IgG measured since she's been on it but will do so in 3 months.

[Kathy4Him]

GI Protect™

 

Featuring IgG 2000 DF™ & L-Glutamine

 

GI Protect™ features XYMOGEN’s IgG 2000 DF™, with the added benefit of the amino acid L-glutamine. IgG 2000 DF represents a breakthrough in immunoglobulin supplementation. It is a highly concentrated, non-dairy source of serum-derived immunoglobulin antibodies and immunoproteins. It possesses three times more immunoglobulin G (IgG) and total immunoglobulins than colostrum and has twice as much cysteine, an important amino acid for maintaining glutathione levels. Compared to colostrum alone, IgG 2000 DF delivers 15 times the level of transferrin and lactoferrin. These and other immunoproteins contained in IgG 2000 DF have demonstrated an ability to enhance immune function by directly boosting immunoglobulin levels in the gastrointestinal tract.*

 

One daily dose of GI Protect provides over 2000 mg of IgG as well as 1000 mg of L-glutamine, which is added to support intestinal mucosal barrier integrity. GI Protect™ is naturally flavored and tastes great, making it easy to consume.*

 

Supplement Facts below represent GI Protect™ Wild Cherry

 

 

Supplement Facts

 

Serving Size: 1 Scoop (10.5 g)

Servings Per Container: 31

 

Amount Per Serving

 

% Daily Value†

 

 

Calories 35

Total Carbohydrate 6

2%

 

Sugars 6 g

 

Protein 2 g

 

IgG 2000 DF™ (Serum-derived immunoglobulin concentrate providing IgG, IgA, IgM, IgE, IgD. Also provides transferrins, IGF-1, and TGFß-1)

 

2.5 g

 

Immunoglobulin G (IgG)(from IgG 2000 DF™)

 

1.125 g

 

L-Glutamine 1 g

 

 

†Percent Daily Values are based on a 2,000 calorie diet.

**Daily Value not established.

All XYMOGEN® Formulas Meet or Exceed cGMP Quality Standards.

[Kathy4Him]

My dd13 has been taking IgG2000 for about a month suggested by Dr. O'Hara as a step-down from IVIG. Her last IVIG was in Aug 2012, with one 16 weeks before that and 8 to 9 week intervals before that. So far, she is holding steady with her progress. She takes 2 capsules/day in the morning. We haven't had her IgG measured since she's been on it but will do so in 3 months.

 

 

What brand of capsules do you buy? I think that would be easier than drinking the powder. Thanks!

[JAG10]

It is also Xymogen EP

IgG 2000 DF vegetable capsules

 

I ordered online, not from her office.

[Kathy4Him]

It is also Xymogen EP

IgG 2000 DF vegetable capsules

 

I ordered online, not from her office.

 

 

Thanks....I think capsules would be easier for my son at this point. I am waiting to get the ok from his treating Dr.

[beeskneesmommy]

I contacted the company and asked some questions i felt were pertinent. Sounds like an interesting product. Here is the Q&A:

 

ME: Is the primary ingredient (immunoglobulins) collected from humans or bovine?

 

REP: Greetings and Good Day!

 

Thank you for your inquiry. The serum in which the immunoglobulins are derived from come from bovine.

 

Your interest in Xymogen products is much appreciated. Should you require any further assistance, please do not hesitate to contact us. Have a great day! J

 

Best regards,

Kyra

 

ME:I do have another question, thank you. How well filtered is the product for infection, particularly prions?

 

REP: Our product specialist stated this:

 

“It is extremely well filtered. In fact it is tested for contamination with prions. Equipment removes all somatic cells so it is safer than a bite of meat or sip of milk.

In the flip side products that are colostrum based have such high levels of somatic cells that if they were sold as a dairy product like milk they would be banned from EU and US for having too many.”

 

I hope this helps!

 

Best regards,

Kyra

Edited January 16, 2013 by Beeskneesmommy

[Fixit]

Anyone have anything to report on this product? Good Bad?

 

glutimine sounds great...but if leaky gut..wouldn't that possibly leave it in the form of glutimate if not absorbed properly and not glutithione?

[ThinkGutBacteria]

Anyone have anything to report on this product? Good Bad?

 

glutimine sounds great...but if leaky gut..wouldn't that possibly leave it in the form of glutimate if not absorbed properly and not glutithione?

 

Terms can get confusing but glutamine is food for cells of the intestine. Much of it gets metabolized into things like citrulline, proline, alanine, glycine, and arginine. It does seem to raise gut glutathione levels in rodent models (studies on mice and rats).

 

As for studies in humans, some show it can improve the outcome of gut infections, ostensibly by improving leaky gut caused by microbe toxins, although studies in people with Crohn's disease (a permanent gut infection, of sorts) have been disappointing. Glutamine's efficacy seems to depend on the disease you're treating.

Edited February 27, 2013 by ThinkGutBacteria

[sf_mom]

We have used both and currently giving Glutamine. I could not tell if the XYMOGEN helped at the time. However, DD has had huge improvements since starting Glutamine but we also started her on specific digestive enzymes (no Butyrate, low pancreatic function, etc), specific vitamins/minerals and hit yeast/fungus very hard when starting Glutamine. One of them, or all of them are working. She gain 3 pounds since Christmas... was 46 pounds and now almost 50 pounds. Her face is fuller, skin tone better, much happier, better attention, etc.

[ThinkGutBacteria]

SF Mom, I love the idea of butyrate. That's gotta help. What supp do you use?

[sf_mom]

Our DD is currently 5. Her symptoms are more ASD in presentation than PANs. Her twin brother and older brother have more typical PANs presentation. All have high viral load, numerous chronic infections (gestational lyme et al), food allergies, heavy metal issues, vitamin/mineral deficiencies, etc. I have Lyme et al as well.

 

We see an LLMD and a pediatrician who specializes in treating Autism biomedically. Our Autisum specialist focuses on gut issues, vutamin/mineral deficiencies, heavy metals while our LLMDs focuses on chronic viral/bacterial infections.

 

I wanted to give you a little background because we've had a lot of help addressing our children's gut issues along the way. DD's current protocol for gut issues is the following: bentonite clay, probiotics 'rotation', Ribose powder, Glutamine powder, digestive enzymes prior to each meal (TriEnza Chewable by Houston Enzymes), higher dose B-12. Older son is on a similar protocol plus a mast cell stabilizer cromolyn (very helpful). They are also dairy free (dairy/casien allergies) and mostly gluten free (do not have gluten allergies). We have treated for parasites (both herbals and anti- parasitics) and also supplemented with MSM 'sulphur' which is good for oxidative stress and treating parasites specifically nematodes.

 

We do not specifically supplement with butyrate. Both DD and I have very low butyrate and low pancreatic function while my sons do not. I thought the comments below might be helpful to you.

 

 

Raising butyrate levels and reducing the permeability of the intestinal barrier can have far reaching consequences for our health that extend beyond the gastrointestinal tract. Consequently, nutritional support is key.

 

Increasing fiber intake through consumption of a fiber supplement is one of the easiest ways to increase butyrate levels in the body. Fiber is well known for its ability to protect against colon cancer and its ability to raise butyrate levels is thought to be one of the main ways in which it protects the colon. The benefits of dietary fiber on inflammatory bowel disease may also be related to the production of butyrate that occurs when fiber is fermented in the colon. Butyrate appears to decrease the inflammatory response.8

 

Combining fiber and a good probiotic with specific botanicals, amino acids and fatty acids known to reduce intestinal permeability can provide additional support for the colon. Phosphatidylcholine, for example, can enhance butyrate’s ability to inhibit colon cancer cells, and therefore works well with fiber to strengthen the intestinal environment.9

 

The amino acid glutamine is one of the most powerful tools for reducing intestinal permeability, thereby protecting the body against the negative consequences of a leaky gut. In a recent review, researchers studied the medical literature to determine if glutamine was effective in reducing intestinal permeability in critically ill patients. In this group of patients, intestinal permeability can have particularly lethal consequences, causing bacteremia, sepsis, and multiple organ failure syndrome. After studying the medical literature, the scientists concluded that glutamine administration by the intravenous or oral route has a protective effect that prevents or reduces the intensity of the increase in intestinal permeability. Glutamine also reduces the frequency of systemic infections.10

 

- See more at: http://www.vrp.com/digestive-health/beyond-probiotics-hidden-causes-of-gi-dysfunction#sthash.A5IVBiXB.dpuf

[JenniferG]

On 1/14/2013 at 8:05 PM, JAG10 said:

My dd13 has been taking IgG2000 for about a month suggested by Dr. O'Hara as a step-down from IVIG. Her last IVIG was in Aug 2012, with one 16 weeks before that and 8 to 9 week intervals before that. So far, she is holding steady with her progress. She takes 2 capsules/day in the morning. We haven't had her IgG measured since she's been on it but will do so in 3 months.

Is she still taking this with success?  Thanks