CD57

[mdmom]

I know some docs use it, some don't.

 

My son started with a CD57 of 13 last April 2011. His level just came back at 9. Anyone seen such a low CD57?

[NancyD]

Not that low but my DD started out with 24 and 18 mos later after agressive treatment she scored a 20. Don't get it...

[rowingmom]

My DD10's CD57 started out at 18 in June 2011. It went up to 27 in Jan 2012, but is now back down to 18. I think Michael Tampa had something to say about the use of CD57 values in children earlier this year.

 

http://www.ncbi.nlm.nih.gov/pubmed/20733159

 

"Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 is a marker of terminal differentiation on human CD8(+) T cells. Very few newborn or fetal NK cells express CD57; however, the frequency of CD57-bearing NK cells increases with age."

[MichaelTampa]

My DD10's CD57 started out at 18 in June 2011. It went up to 27 in Jan 2012, but is now back down to 18. I think Michael Tampa had something to say about the use of CD57 values in children earlier this year.

 

http://www.ncbi.nlm.nih.gov/pubmed/20733159

 

"Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 is a marker of terminal differentiation on human CD8(+) T cells. Very few newborn or fetal NK cells express CD57; however, the frequency of CD57-bearing NK cells increases with age."

 

 

Some docs say this test is inapplicable for those younger than perhaps 13 or 15, as they say people younger than these ages just naturally do not have much CD57, even when completely healthy. I believe I did see one other poster mention a single-digit CD57, also for a child. It's very low, for sure! Perhaps it is inapplicable due to age, I don't really know about that, other than some docs don't use it at those ages, and then others due.

[mdmom]

Thanks for replies everyone.

 

My son is 15, so I'm not sure where that puts him - child or adult.

 

We will see LLMD in 2 weeks, so I'll be curious of doc's opinion.