eljomom Posted January 30, 2011 Report Posted January 30, 2011 Just got another post from Tourette Disorder, Pandas and Mental Health, with a link to this article. Madeline Cunningham is in it. I really wonder what the drug is they are talking about for treating Syd. Chorea? Also, it mentions that it works on D2 receptors, but that D1 and D2 are effected by the strep antibodies. We only have high D1---still would love to know just what that means, and how do you get the anti D1 brain antibodies lower??
GraceUnderPressure Posted January 31, 2011 Report Posted January 31, 2011 Do you have a link to the article or the title so we can search for it?
MomWithOCDSon Posted January 31, 2011 Report Posted January 31, 2011 (edited) Just got another post from Tourette Disorder, Pandas and Mental Health, with a link to this article. Madeline Cunningham is in it. I really wonder what the drug is they are talking about for treating Syd. Chorea? Also, it mentions that it works on D2 receptors, but that D1 and D2 are effected by the strep antibodies. We only have high D1---still would love to know just what that means, and how do you get the anti D1 brain antibodies lower?? I'd sure like to know, too! On the WeMove site, in addition to the lead-off paragraph about the importance of antibiotics, I found the following: As Sydenham's chorea may spontaneously resolve or not cause significant functional impairment, many experts indicate that treatment with certain medications, such as dopamine blockers (antagonists), should be avoided unless associated chorea is functionally disabling or associated with potentially violent flailing motions of the limbs that may result in self-injury. Dopamine antagonists, such as the antipsychotic agents haloperidol (Haldol®) or pimozide (Orap®), may have potentially severe adverse effects, including the development of tardive dyskinesia. First-line therapy with the anticonvulsant medication valproate sodium (Depakene®) may be beneficial for some patients with Sydenham's chorea. Pimozide is usually reserved for those patients who fail to respond to valproate or who present with severe forms (i.e., chorea paralytica). If these two options fail, the next steps may include immunomodulatory treatment, steroids, IV IgG, or plasmapheresis. Then, when querying "dopamine agonist," I get the following indications: Examples of dopamine agonists include: Parlodel (bromocriptine) Dostinex (cabergoline) Permax (pergolide) - Removed from market in America March 29, 2007 Mirapex and Sifrol (pramipexole) Requip (ropinirole) Apokyn (apomorphine) Neupro (rotigotine) Norprolac (Quinagolide) Some, such as fenoldopam, are selective for dopamine receptor D1. By the way, though, fenoldopam is in the benzo class of drugs, so these appear to be "psych" drugs as opposed to something working specifically on immune or physical/health function. Edited January 31, 2011 by MomWithOCDSon
dut Posted January 31, 2011 Report Posted January 31, 2011 Hi 0 when our dd got her diagnosis 2-3 years ago, I spoke to Dr Leckman and he mentioned a drug, available in Canada and UK but not US, that acted as a dopamine agonist.. can't remember the name, don't think it was one of those on the list.. He said that it could possibly be used for PANDAS patients. I'll have to go check my notes.. will post it if I find it.. wonder if that was the one?
eljomom Posted January 31, 2011 Author Report Posted January 31, 2011 Dut--would love to know! MOM-thanks for the detail:) Wonder what anti-tic drugs are then---agonists or antagonists? Like Tenex?
lfran Posted January 31, 2011 Report Posted January 31, 2011 I would love to know a med that worked on D2 receptors specifically. DS9 had the highest D2 antibodies on the Cunningham test that I have seen posted yet -- they were 32000. All else were at the high end of normal range. Any more info would be great! Thanks! Dut--would love to know! MOM-thanks for the detail:) Wonder what anti-tic drugs are then---agonists or antagonists? Like Tenex?
rockytop Posted January 31, 2011 Report Posted January 31, 2011 (edited) Thanks so much for posting this eljomom!! this maybe explains why Risperdal (also a D2 antagonist) was so extremely helpful to my child with high D2. Maybe the wemove. post also lends creedence to the explain of why after over 2 1/2 years of major psychiatric diagnoses and puzzles and almost a year of chorea-like movement and body wriggles at rest and strong truncal "tics" - my child seems to be having some "spontaneous" improvement. Spontaneous in that she is not on any medication, no has been for over 6 weeks! On Christmas eve her movements were so bad it was difficult for her to be still even while reading-- now she is hardly wriggling or ticcing at all and her OCD is iproving by leaps and bounds. Maybe it is just "going away"? Maybe 9 months of D2 antagonizing brought her to this place? Is there anyone anywhere who knows the answer to this? lfran-- Have tried risperdal? it was the last in a long line of drugs for us and it put out the "fire" that was in her brain- Edited May 26, 2011 by rockytop
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