Info on so called double starred and non specific Lyme bands

[sptcmom]

There is an LLMD called Dr Crist. I don't know where just found this dialogue while browsing. Here is the Bands info I found.

 

30 kDa is outer surface protein A, like the 31. It is in the medical literature that they are the same and I (Dr. Crist) have talked to one of the world experts on ospA and she said the 30 and 31 are the same. It is just like the 23,24,25 being the same outer surface protein but of different weights. This lab (Igenex) does not put two "**" in front of the 30 but it is a classic hallmark Lyme antibody with 97% correlation with antibiotics helping. (I will say this is the reason Dr. Crist said I should have a positive because of my #30 positive because it is the same as #31)

 

39 kDa is from the inner part of the borrelia burgdorferi bacteria called the endocytoplasmic reticulum. It is the reddest flag of all the sixteen antibodies on the blot. Other bacteria that are like the Lyme bacteria (borrelia recurrentis, etc.) do not even have the genetics to code for this, much less produce it. The 39 appear to be unique to Lyme bacteria. It has even been suggested that a 39 by itself is enough to be a positive test.

 

41 kDa is the flagella or tail or the Borrelia burgdorfri and that is how it moves around, by moving the flagella. It is the most common Lyme antibody of all. Even though different bacteria (E coli, etc) may have flagella and possibly cause a false positive test result, there is a 90 to 97% correlation with a 41 and antibiotics helping.

 

58 kDa is a heat shock protein that helps the Lyme bacteria survive fever. It was shown at the international Borreliosis conference held in Germany in 1999 to be a significant Lyme antibody. This lab (Igenex) does not put ** after it but it should not be ignored.

 

66 kDa is the second most common antibody found and is also heat shock protein. It is not given significance because different bacteria may produce it, even though it is the second most commonly found Borrelia burgdorferi antibody.

 

93 kDa is the DNA, genes, or genetic material of Borrelia burgdorferi. This lab (Igenex) considers the IgG 93 to be significant, but not the IgM antibodies. I (Dr. Crist) disagree with this. A 93 IgM is tightly associated with antibiotic responsiveness.

 

I found answers to the bands I was looking for (58 and 66). The entire info is very informative.Dr Crist reads IND as = almost positive and treats as positive. So does my LLMD and DS's LLMDs and even without knowing who Dr Crist is, its good to see consensus.

Jodie

Edited January 14, 2011 by sptcmom

[sptcmom]

Found him! Dr Charles Crist of Missouri, LLMD

Here is his website- very informative

 

http://www.drcharlescrist.com/testing.htm

[aidansmom]

Found him! Dr Charles Crist of Missouri, LLMD

Here is his website- very informative

 

http://www.drcharlescrist.com/testing.htm

very interesting.

Does anyone know of this Dr. Crist? He is in my Dad's home town.

[Fixit]

There is an LLMD called Dr Crist. I don't know where just found this dialogue while browsing. Here is the Bands info I found.

 

30 kDa is outer surface protein A, like the 31. It is in the medical literature that they are the same and I (Dr. Crist) have talked to one of the world experts on ospA and she said the 30 and 31 are the same. It is just like the 23,24,25 being the same outer surface protein but of different weights. This lab (Igenex) does not put two "**" in front of the 30 but it is a classic hallmark Lyme antibody with 97% correlation with antibiotics helping. (I will say this is the reason Dr. Crist said I should have a positive because of my #30 positive because it is the same as #31)

 

39 kDa is from the inner part of the borrelia burgdorferi bacteria called the endocytoplasmic reticulum. It is the reddest flag of all the sixteen antibodies on the blot. Other bacteria that are like the Lyme bacteria (borrelia recurrentis, etc.) do not even have the genetics to code for this, much less produce it. The 39 appear to be unique to Lyme bacteria. It has even been suggested that a 39 by itself is enough to be a positive test.

 

41 kDa is the flagella or tail or the Borrelia burgdorfri and that is how it moves around, by moving the flagella. It is the most common Lyme antibody of all. Even though different bacteria (E coli, etc) may have flagella and possibly cause a false positive test result, there is a 90 to 97% correlation with a 41 and antibiotics helping.

 

58 kDa is a heat shock protein that helps the Lyme bacteria survive fever. It was shown at the international Borreliosis conference held in Germany in 1999 to be a significant Lyme antibody. This lab (Igenex) does not put ** after it but it should not be ignored.

 

66 kDa is the second most common antibody found and is also heat shock protein. It is not given significance because different bacteria may produce it, even though it is the second most commonly found Borrelia burgdorferi antibody.

 

93 kDa is the DNA, genes, or genetic material of Borrelia burgdorferi. This lab (Igenex) considers the IgG 93 to be significant, but not the IgM antibodies. I (Dr. Crist) disagree with this. A 93 IgM is tightly associated with antibiotic responsiveness.

 

I found answers to the bands I was looking for (58 and 66). The entire info is very informative.Dr Crist reads IND as = almost positive and treats as positive. So does my LLMD and DS's LLMDs and even without knowing who Dr Crist is, its good to see consensus.

Jodie

 

wow ..thanks so much.....i will try to report tomorrow, on my NC llmd visit..he runs caustious...have apt with doc b in md 2/2/11..will be ready with this new info...

[Fixit]

does anyone know??? or have idea...on band 39

 

when they say specific...does that mean there is no cross reactivity...it would only glow if it were lymes and no other illness??

[sptcmom]

does anyone know??? or have idea...on band 39

 

when they say specific...does that mean there is no cross reactivity...it would only glow if it were lymes and no other illness??

 

here is the part about 39. Is this what you wanted?

 

39 kDa is from the inner part of the borrelia burgdorferi bacteria called the endocytoplasmic reticulum. It is the reddest flag of all the sixteen antibodies on the blot. Other bacteria that are like the Lyme bacteria (borrelia recurrentis, etc.) do not even have the genetics to code for this, much less produce it. The 39 appear to be unique to Lyme bacteria. It has even been suggested that a 39 by itself is enough to be a positive test.

[Fixit]

edit

 

yes...thank you!

 

edit...i'm having have a senior moment.....i read that last night, i was a little tired....but just noticed the reddest flag part....

do we know any other bacteria...(as in the case of 41) can cause this to show up...

 

Oh..and what was the internal bug you get from lakes...gardia...can that look like band 41?? or other flagilyn type things

Edited January 15, 2011 by Fixit

[chodnett]

has anyone taken PANDAS child with band 41 to Dr.C?

What does he say about band 18?