More on Th17

[dut]

http://www.ualberta.ca/~medlabsc/courses/475/Th17lymphocytesbbb.pdf

[Buster]

Yes, that's a great paper. Even more interesting is this paper by Cleary and Wang: http://www.pnas.org/content/107/13/5937.full.pdf+html

 

For those who don't love reading about TNF-Beta and T-Helper cell type 17 and Interleukin 17....

 

What Wang and Cleary found was that (in at least mice), if they sprayed GABHS into the noses of the mice (i.e., just nasal colonization -- not infection), the mice produced abnormal amounts of Th17. Th17 is highly implicated in auto-immune diseases.

 

Curiously, if they innoculated the mice with GABHS in the blood stream, the mice produced Th1 (i.e., non-auto-immune response).

 

The significance of this is not known and whether the result also happens in people is not known -- but awfully interesting.

 

Buster

 

http://www.ualberta.ca/~medlabsc/courses/475/Th17lymphocytesbbb.pdf

Edited October 30, 2010 by Buster

[Fixit]

http://www.ualberta.ca/~medlabsc/courses/475/Th17lymphocytesbbb.pdf

 

actually i do enjoy reading this...

but it takes an hour of uninteruppeted reading to digest 25% of it..make that 5%...

 

dut can you link the other articles to this one..would be handy...

Edited October 30, 2010 by Fixit

[T_Mom]

Good heavens, that is interesting...The fact that with her worst exacerbation our d had nasal "congestion" (no positive throat or blood strep) is right in line with this entire scenario. I can't really follow the article -- way beyond me, but Buster's comments hit home. Thanks for posting it.

Edited October 31, 2010 by T.Mom