cd8 count

[norcalmom]

I'm just getting ready for our conference call with Dr K on wednesday. Immuno work up just came back. DS has low CD8 % positive - 16 (range 17-35%) so not that low. Also high CD4/cd8 ratio 3.08 (1.0-2.8).

 

These percentages are off do to low, but in range Absolute CD8 count of 307 (300-900)

 

also low total IGG 699 (821-1835) and subclass IGG 1 low 386 (423-1080)

 

These amounts don't look too far out of range to me. I'd like 'em to be just enough out of range to qualify for insurance coverage of IVIG , but doens't look like it, although I have no idea if a small delta is significant or not. Also not much information out there on CD8.

He's pretty heathly if you take pandas out of the picture. No allergies, no more upper resperatory infections that the average kids (4? year), minor cough/colds that resolve on own.

 

But what is CD8?

[sptcmom]

Here is an info link.

 

http://www.labtestsonline.org/understandin...cd4/sample.html

 

Ofcourse the HIV part doesnot apply to us at all. The basic info and the coinfection with myco part applies to us .

 

 

- Jodie

Edited July 13, 2010 by sptcmom

[norcalmom]

Thanks Jodi- that was a good site. The ones I found really talked exclusively about HIV.

[Buster]

I'm just getting ready for our conference call with Dr K on wednesday. Immuno work up just came back. DS has low CD8 % positive - 16 (range 17-35%) so not that low. Also high CD4/cd8 ratio 3.08 (1.0-2.8).

...

But what is CD8?

 

Well, CD stands for Cluster of Differentiation which refers to proteins exposed on the surface of T-cells. When you get flow cytometry, they are checking the amount or count of these proteins.

 

CD-4 is on T-helper cells. T-helper cells tend to progress to Th2 cells that become antigen presenting cells to trigger B-cell production of antibodies. CD-8 cells tend to be direct suppressors and morph into cytotoxic T-cell (i.e., things that kill cells). So you can think of CD-4 as going to extracellular/indirect suppression and CD-8 as going after intracellular/direct suppression.

 

CD4 and CD8 ratios are affected by things like azithromycin, progesterone, and a number of other things.

 

Buster

[norcalmom]

Thank you Buster! I couldn't find any info on why ds's CD8 might be low (maybe the azith?). All the stuff I found talks about low CD4, and a low cd4 to cd8 ratios (ours is opposite, CD4 normal, CD8 low)..but nothing I found even mentions low CD8.

 

-Kerry

[Buster]

Was it the % or ratio that was off or the actual count.

 

Keith

Thank you Buster! I couldn't find any info on why ds's CD8 might be low (maybe the azith?). All the stuff I found talks about low CD4, and a low cd4 to cd8 ratios (ours is opposite, CD4 normal, CD8 low)..but nothing I found even mentions low CD8.

 

-Kerry