Very interesting paper on Acute Rheumatic Fever

[Buster]

There's a really interesting paper on Acute Rheumatic Fever called

Some of the People, Some of the Time

Susceptibility to Acute Rheumatic Fever

in the Feb 2009 issue of Circulation (see http://circ.ahajournals.org/cgi/reprint/119/5/742.pdf.

 

They found that even with ourbreaks of the GABHS strain that is known to cause ARF, the incidence of ARF is limited to 3-6%. This is a constant regardless of geography and ethnicity indicating a very strong genetic component to susceptibility.

 

There's a good discussion of genetic predisposition and a good figure that tries to explain the incorrect activation of T-cells from molecular mimicry. Nothing earth shattering in the write up, but good solid research and paper that is helpful as a baseline paper when talking with doctors about PANDAS having similar pathogenesis. Combining this paper with the T-cell crossing the BBB helps strengthen the PANDAS argument.

 

Buster

Edited April 7, 2010 by Buster

[kimballot]

Thanks for sharing, Buster!

[Johnsmom]

Hi there-

 

I cant seem to find this paper. I tried to copy and paste and that didnt work either. Can you re-post?

Thanks

 

 

There's a really interesting paper on Acute Rheumatic Fever called

Some of the People, Some of the Time

Susceptibility to Acute Rheumatic Fever

in the Feb 2009 issue of Circulation (see http://circ.ahajournals.org/cgi/reprint/119/5/742.pdf).

 

They found that even with ourbreaks of the GABHS strain that is known to cause ARF, the incidence of ARF is limited to 3-6%. This is a constant regardless of geography and ethnicity indicating a very strong genetic component to susceptibility.

 

There's a good discussion of genetic predisposition and a good figure that tries to explain the incorrect activation of T-cells from molecular mimicry. Nothing earth shattering in the write up, but good solid research and paper that is helpful as a baseline paper when talking with doctors about PANDAS having similar pathogenesis. Combining this paper with the T-cell crossing the BBB helps strengthen the PANDAS argument.

 

Buster

[kim]

Johnsmom,

 

Try this link

 

http://circ.ahajournals.org/cgi/content/fu.../742#R41-191906

[LNN]

Hi there-

 

I cant seem to find this paper. I tried to copy and paste and that didnt work either. Can you re-post?

Thanks

try this

http://circ.ahajournals.org/cgi/reprint/119/5/742.pdf

 

Buster's link had a parenthesis at the end that made you get a "page not found" error.

[mom md]

I will have to pull the paper tomorrow but very interesting. My nephew started ticcing in the fall and recently was diagnosed with PANDAS. My son has PANDAS. My great aunt had Sydenham's chorea. My grandmother, mother and myself had scarlet fever. My sister (one who's son was recently diagnosed) had post-streptoccocal glomerulonephritis as a child. There is definitely a genetic component here. I am watching my other children very closely.

We pulled out our family tree tonight for a school project and this side of the family has always lived very long (into 90's-100's) even going way back. Makes you wonder if this "hyper" response to strep has some protective capacity but has just gotten out of hand...