Increased Zith Yesterday

[faith]

I believe that if whatever is triggering the inflammation (antibodies and breach in the BBB) is not removed then the inflammation will continue (just be reduced while the advil is in their system).

Monarchcat,

 

I agree. We noticed quite accidentally an improvement on Advil but strangely not on Aleve (we were trying to see about extended release). I later learned that Aleve didn't contain ibuprofen. So it looks like something specific to ibuprofen.

 

Back when I was researching this I found several nice papers on Cox-2 inhibitors in Alzheimer's Disease. I'll track them down.

 

Our immulonogist did think what we were seeing then and from IVIG may be mostly due to the anti-inflammatory properties. He even thought that perhaps the effect we were seeing from azithromycin might be the anti-inflammatory property. It's an interesting thought.

 

Regards,

 

Buster

 

Buster,

so azithromycin is beleived to have anti-inflammatory properties, is that wha the doc meant? and IVIG as well? am I understanding your post correctly?

 

I'm trying with the advil, but my son's hard to gauge, because of the vocal he has, it never fully goes away. but day before yesterday I did think he was doing it more and I gave him one at nite, and I think the next day he seemed less when he came home from school. he was also pretty cheerful last night. so I don't really know, this is something I kind of have to play with and really pay attention on to see if it really is helping.

 

Faith

[Buster]

so azithromycin is beleived to have anti-inflammatory properties, is that wha the doc meant? and IVIG as well?

 

I never know whether people want source material or just answers so I'll do a bit of both.

 

Azithromycin is anti-inflammatory : see http://jac.oxfordjournals.org/cgi/reprint/55/1/10

 

IVIG is highly anti-inflammatory : see http://www.sciencemag.org/cgi/content/abstract/320/5874/373

 

Advil is anti-inflammatory : see http://www.jneuroinflammation.com/content/...2-2094-1-21.pdf

 

The best research at this point indicates that PANDAS is a subgroup of children with OCD/tics where there is :

1. an immune response to GABHS by B-cells creating an anti-neuronal antibody (see http://www.pandasnetwork.org/Cunningham.NMpaper%5b1%5d.pdf )
   
2. a failure of the immune system (T-reg/B-reg) to stop the anti-neuronal antibody (see http://www.journals.elsevierhealth.com/per...0804-3/abstract )
   
3. a breach of the blood-brain barrier that allows the antibody to interact with neuronal tissue (see http://www.jimmunol.org/cgi/reprint/178/11/7412 )
   
4. GABHS can alter the permeability of the Blood-Brain Barrier (see http://iai.asm.org/cgi/reprint/21/3/753.pdf and http://www.neurology.org/cgi/content/abstract/54/7/1433 )
   

So, antibiotics can help to prevent an infection that might lead to #1 and reduce the inflammation in #4

PEX, IVIG can help to address #2 and interestingly #4 (see http://iai.asm.org/cgi/content/abstract/64/12/5395 )

Azithromycin, IVIG, prednisone, advil all seem to reduce inflammation and help close BBB in #3 and in #4

 

There is pretty good evidence that if it isn't PANDAS then the treatments above don't work (because there aren't any antibodies to go after) (see http://www.ncbi.nlm.nih.gov/pubmed/11026187 )

 

 

 

Buster

[peglem]

Buster,

I never know whether people want source material or just answers so I'll do a bit of both.

 

I like when you do both! Sometimes I don't understand the material and you do a wonderful job of explaining it.

 

But also, the source materials often list references that also have good info.

 

BTW- I couldn't get that last link to open.

[faith]

thank you Buster....