Tregs

[kim]

http://www.physorg.com/news108987915.html

 

Immune police recognize good and bad guys in the body

 

Although, the majority of T cells that may harm healthy body tissue are eliminated in the thymus, some errant autoreactive cells can escape and cause autoimmune disease. Tregs previously believed to primarily recognize self-tissue with the idea of protecting it are considered the antithesis of these autoreactive cells.

 

“It was believed that regulatory cells are baptized autoreactive cells,” says Dr. Ignatowicz. “They are like bad boys that went good,” since they also recognize self tissue but seek to protect it.

 

Yet scientists kept running into the reality that some regulatory cells also were recognizing – and potentially protecting – invaders such as bacteria and viruses.

 

 

Another interesting article

 

http://www.physorg.com/news164281904.html

 

GARP makes the difference

 

June 15, 2009 Scientists from the Helmholtz Center for Infection Research in Braunschweig, Germany and the Medical School Hannover, Germany have succeeded in treating immune cells in a way that enables them to inhibit unwanted immune reactions such as organ rejection. Their results have now been published in the current issue of the scientific journal Journal of Cellular and Molecular Medicine.

[Buster]

Yup, it sure seems their part of the problem/solution. They missed locking up the bad antibody. There's a nice paper by Kessel on his thoughts here:

http://www.jimmunol.org/cgi/content/full/179/8/5571

 

Regards,

 

Buster

 

 

http://www.physorg.com/news108987915.html

 

Immune police recognize good and bad guys in the body