S. Pneumonaie Titers Pre-IVIG

[KeithandElizabeth]

Hello:

 

I noticed that several of our children are failing many of the S. Pneumonaie titiers when their blood is drawn previous to their first IVIG. I am wondering if anyone has a child with PANDAS who passed the majority of their 14 S. Pneumonaie titers before they did IVIG or PEX?

 

Elizabeth

[peglem]

We have not done IVIG or PEX and my daughter is too old to have had the prevnar vaccine. @ 2 years ago she saw an immunologist who ran a baseline pneumococcal titer, which she failed, but as I said she hadn't been immunized yet. Then he gave her a pneumovax (not prevnar) and retested after 4 weeks. She failed that and was vaxed 1 more time. She responded to the second one and subsequently showed titer coverage. The immunologist claimed that he had "jump started" her immune system and she would not be getting so many strep infections....he was wrong. The chronic strep persisted...so she must just be a carrier.

[pixiesmommy]

Hi Elizabeth,

 

Hope you are doing well. I think, unfortunately, this is not one that we have had done yet, so I can't comment for us in particular. We're hoping to get all sorts of bloodwork done in January as our immunologist felt that at that point the IVig would have "worn off" but I doubt that we would have identical blood results for things pre and post IVig, so I'm no help at all for these tests!

Curious to see what others report and how it changes pre and post IVig though!

 

Manda

[ShaesMom]

We have not done IVIG or PEX and my daughter is too old to have had the prevnar vaccine. @ 2 years ago she saw an immunologist who ran a baseline pneumococcal titer, which she failed, but as I said she hadn't been immunized yet. Then he gave her a pneumovax (not prevnar) and retested after 4 weeks. She failed that and was vaxed 1 more time. She responded to the second one and subsequently showed titer coverage. The immunologist claimed that he had "jump started" her immune system and she would not be getting so many strep infections....he was wrong. The chronic strep persisted...so she must just be a carrier.

 

Either that or she just wasn't able to hold the titers results for an extended period of time. It would be interesting to see what her response would be to the Pneumo titers blood work two years later.

[peglem]

We have not done IVIG or PEX and my daughter is too old to have had the prevnar vaccine. @ 2 years ago she saw an immunologist who ran a baseline pneumococcal titer, which she failed, but as I said she hadn't been immunized yet. Then he gave her a pneumovax (not prevnar) and retested after 4 weeks. She failed that and was vaxed 1 more time. She responded to the second one and subsequently showed titer coverage. The immunologist claimed that he had "jump started" her immune system and she would not be getting so many strep infections....he was wrong. The chronic strep persisted...so she must just be a carrier.

 

Either that or she just wasn't able to hold the titers results for an extended period of time. It would be interesting to see what her response would be to the Pneumo titers blood work two years later.

I agree. We're awaiting the results of her IgG subclasses right now. Total IgG is a bit low, IgA is VERY low, but IgA was only slightly low 2 years ago. Her pediatrician is running the immune panel himself, to see what, if anything he can offer the immunologist as proof of immune deficiency. The pediatric immunologist in Phoenix played the autism card to explain her behavior 2 years ago.

[bronxmom2]

I'm waiting for pre-IVIG numbers right now... I'll post when I get them. At this point I'll be surprised if my son doesn't fail the S. Pneumonaie titers... increasingly, this seems to be the smoking gun.

[sf_mom]

My son failed 10 of the 14 serotypes and we'll be getting our IgG subclass results tomorrow all taken pre-IVIG. I hope to retest everything in 6 month post IVIG to see if there are any changes.