kim Posted September 21, 2007 Report Share Posted September 21, 2007 Has anyone seen this? It's all perfectly clear now! http://www.jimmunol.org/cgi/content/abstract/178/11/7412 Link to comment Share on other sites More sharing options...
Mustang Carole Posted September 21, 2007 Report Share Posted September 21, 2007 Hi Kim, Here is the interpretation regarding your article...this is a cross posted answer from an immuno person... They isolated three antibodies from patients with Syndeham's chorea and looked for the corresponding human protein target. The results suggested beta tubulin was a likely target though another protein, lysoganglioside, blocked the antibody form binding to tubulin which suggests and alternate target or crossreactive sequence in both proteins. Since the three antibodies were chosen for their ability to recognize strep proteins, it may also offer a mechanism whereby strep infection can trigger the production of autoantibodies toward brain proteins. M.C. Link to comment Share on other sites More sharing options...
kim Posted September 22, 2007 Author Report Share Posted September 22, 2007 Carole, Thanks for the response. This is obviously way over my head, but this sentence, I think, may have to do with what Dr. Pessah was talking about when he spoke of the peptide clip being disrupted (?) allowing empty space on the cells surface, where self proteins may be picked up Nucleotide sequence analysis of the chorea mAb VH genes revealed that mAb 24.3.1 VH gene was encoded by the VH1 germline gene family which encodes other anti-ganglioside VH genes associated with motor neuropathies. mAb recognition of tubulin and the neuronal cell surface with initiation of cell signaling and dopamine release supports an emerging theme in autoimmunity whereby cross-reactive or polyreactive autoantibodies against intracellular Ags recognize cell surface epitopes potentially leading to disease. Can you by any chance point me to a forum where this has been discussed? Dr. Pessah started that lecture with discussion of the rise in allergies. I found the whole thing to be so interesting. Just wish I could understand more of it. Link to comment Share on other sites More sharing options...
Mustang Carole Posted September 23, 2007 Report Share Posted September 23, 2007 Hi Kim, No discussion , just a question on the autism immune forum by me and one response. http://health.groups.yahoo.com/group/Autism-Immune/ Lots of interesting stuff over there that is way over our heads, LOL! M.C. Link to comment Share on other sites More sharing options...
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