peglem Posted August 17, 2013 Report Share Posted August 17, 2013 http://www.ijhg.com/article.asp?issn=0971-6866%3Byear%3D2013%3Bvolume%3D19%3Bissue%3D2%3Bspage%3D196%3Bepage%3D201%3Baulast%3DLuleyap Link to comment Share on other sites More sharing options...
qannie47 Posted August 17, 2013 Report Share Posted August 17, 2013 WOW!!!!!!!!!!!! Link to comment Share on other sites More sharing options...
pr40 Posted August 17, 2013 Report Share Posted August 17, 2013 can you understand this study? what is "AA polymorphism of −308 G/A polymorphism"? a gene mutation? Link to comment Share on other sites More sharing options...
peglem Posted August 17, 2013 Author Report Share Posted August 17, 2013 can you understand this study? what is "AA polymorphism of −308 G/A polymorphism"? a gene mutation? That was my understanding, but wanted Buster's take on it. Link to comment Share on other sites More sharing options...
LNN Posted August 17, 2013 Report Share Posted August 17, 2013 (edited) For those of you wanting to check your 23andMe raw data, these are the snp IDs TNF - 308 is rs1800629 with the wild type/ancestoral allele of G and the risk allele of A (so if you have GG this snp is normal, if you have AA you're homozygous +/+) Per snpedia, The (A) allele is associated with higher levels of TNF expression. This SNP has been linked to a wide variety of conditions: asthma, COPD, Crohn's, Grave's, heart disease, leprosy and lymphoma. http://snpedia.com/index.php/Rs1800629 TNF -850 is rs1799724 with the wild type allele of C and the risk allele of T. It is linked to an increased risk of alzheimer's, glaucoma, and other illnesses. http://snpedia.com/index.php/Rs1799724 but the research paper didn't find a link between Pandas and this snp. Edited August 18, 2013 by LLM Link to comment Share on other sites More sharing options...
qannie47 Posted August 18, 2013 Report Share Posted August 18, 2013 Yeah, read the whole thing....it was a bit like giving birth....for a laywoman, such as myself, I was excited to take away the understanding that they have found a gene mutation that can be linked to Pandas....86.5% in Pandas group and none in the control group.....just think what that could mean!!! A blood test down the road that proves that we are not crazy!!! Insurance coverage!!!! Link to comment Share on other sites More sharing options...
peglem Posted August 18, 2013 Author Report Share Posted August 18, 2013 Thanks, LLM! I wondered if this was something 23&me tested for. Link to comment Share on other sites More sharing options...
cobbiemommy Posted August 18, 2013 Report Share Posted August 18, 2013 DS, just had testing done for tumor necrosis factor, not genetic, but for the presence of the antibodies. So is the treatment the same, IVIg?? We do not have any test results yet. This is great news for everyone. Link to comment Share on other sites More sharing options...
T_Mom Posted August 18, 2013 Report Share Posted August 18, 2013 This article is amazing!!!! How can we thank these people, what an amazing group of researchers!!! THANK YOU!!!! Must admit, I understand little of this or the implications--We need a Buster interpretation, as to the ramifications of this research for our children and treatment!!!!! Link to comment Share on other sites More sharing options...
norcalmom Posted August 18, 2013 Report Share Posted August 18, 2013 Great find Peglam! Thanks for posting. It's a very small study, and very specific to strep, and Turkey, but exciting to see they are looking at this in our kids. I guess Turkey has a lot of untreated strep, (according to the article) and maybe a genetic variation in their population (my interpretation if the data- since only done on Turks). Go to the SNPepedia page LLM references above (thanks LLM!)- having the AA allele is associated with a number of risk factors, as well as even some benefits(lowered risk if MS) And- if you read the psoriasis summary- if you have the AA allele and you're polish you have increases risk, but if you have the allele and you're Irish, decreased risk. My pandas son does not have the AA allele. Our whole family is GG. Having the gene may put you at higher risk for getting pandas ( especially if you are Turkish, and have strep as trigger) - but it's just a risk factor. This looks like somewhat common. It isn't one of those gene mutations that mean you definitely have or will get a disease, for those of you reading that haven't done any genetic testing/research. Great find. We're getting there! EAMom 1 Link to comment Share on other sites More sharing options...
EAMom Posted August 18, 2013 Report Share Posted August 18, 2013 It would be great if those who have done the 23andme would post if their PANDAS kid is AA, AG, or GG. Norcalmom is correct that these results may apply those of Turkish decent, not necessarily everyone. So, it would be super interesting to see what folks here are getting. Link to comment Share on other sites More sharing options...
peglem Posted August 18, 2013 Author Report Share Posted August 18, 2013 (edited) Great find Peglam! Thanks for posting. It's a very small study, and very specific to strep, and Turkey, but exciting to see they are looking at this in our kids. I guess Turkey has a lot of untreated strep, (according to the article) and maybe a genetic variation in their population (my interpretation if the data- since only done on Turks). Go to the SNPepedia page LLM references above (thanks LLM!)- having the AA allele is associated with a number of risk factors, as well as even some benefits(lowered risk if MS) And- if you read the psoriasis summary- if you have the AA allele and you're polish you have increases risk, but if you have the allele and you're Irish, decreased risk. My pandas son does not have the AA allele. Our whole family is GG. Having the gene may put you at higher risk for getting pandas ( especially if you are Turkish, and have strep as trigger) - but it's just a risk factor. This looks like somewhat common. It isn't one of those gene mutations that mean you definitely have or will get a disease, for those of you reading that haven't done any genetic testing/research. Great find. We're getting there! Not my find- A Canadian parent posted it to our local group. Are these the same researchers that did the young adult PANDAS IVIG case studies? Edited August 18, 2013 by peglem Link to comment Share on other sites More sharing options...
EAMom Posted August 18, 2013 Report Share Posted August 18, 2013 Norcalmom...I have heard from a couple of PANDAS moms in another group and both their kids are GG as well. So, you are right that this may only apply to Turks. Hopefully more will chime in. Link to comment Share on other sites More sharing options...
TinyTreasures Posted August 18, 2013 Report Share Posted August 18, 2013 Very interesting, thank you for posting! My son is 3.5 and is type GG for the SNP rs1800629, however I don't believe his trigger is strep. He has never come back positive for strep - throat swaps and bloodwork. Awaiting Cunningham Panel results. Link to comment Share on other sites More sharing options...
lfran Posted August 18, 2013 Report Share Posted August 18, 2013 Ds12 is gg Link to comment Share on other sites More sharing options...
Recommended Posts
Create an account or sign in to comment
You need to be a member in order to leave a comment
Create an account
Sign up for a new account in our community. It's easy!
Register a new accountSign in
Already have an account? Sign in here.
Sign In Now