OAT test

[philamom]

Great Plains Lab "OAT" test

 

Flagged Markers:

 

Yeast & Fungal:

Arabinose- 146 H (ref <56)

 

Oxalate Metabolites:

Glycolic- 252 H (ref 20-202)

 

Neurotransmitter Metabolites:

Quinolinic/5-HIAA Ratio- 6.2 H (ref .04-2.2)

 

Ketone-Fatty Acid Oxidation:

3-Hydroxybutyric- 5.7 H (ref <4.1)

Sebacic- .40 H (ref <.37)

 

Nutritional Markers:

Vit C- 3.0 L (ref 10- 200)

 

Detox:

2-Hydroxyhippuric- 27 H (ref <1.2)

 

Amino Acid Metabolites:

Phenylactic- 0.53 H (ref <0.27)

4-Hydroxyphenylactic- 3.0 H (ref .04-1.1)

3-Methylglutaric- 1.6 H (ref .07-.95)

[SSS]

Hi- I'm sure you've been to Great Plains Labratory website and seen this, but in case not:

http://www.greatplainslaboratory.com/home/eng/full_oat.asp

 

When I had a few done on my dd, GPL also used to offer a free phone consult with an RN to briefly go over results.

 

One time they told me Vitamin C always registers low, since it is a water soluable vitamin, and leaves the body so rapidly.

 

So, you've got an obvious yeast problem. Antifungals need to be on board, and a diet change, probiotics, you know this stuff.

Oxalate are high-not crazy high, but here is some information-

http://www.stopthethyroidmadness.com/oxalates/

 

In the bio-med/autism recovery world, some people think oxalates are a big deal. Maybe a few easy food adjustments can help.

 

Also, don't know if your dd is gluten free, but some of your Amino acid metabalites suggest it may be a good idea

http://www.greatplainslaboratory.com/home/eng/Clinical%20Significance%20of%20the%20OAT.pdf

 

The B vitamin thiamine may be helpful as well.

Just what I'm seeing from the interpretive guide.

[philamom]

Thanks S&S - I will call and inquire about a free consult. The ordering dr. just suggested diflucan. I was a little concerned about the very high Quinolinic/ 5HIAA ratio. The interpretation suggests neural excitotoxicity of NMDA-type receptors. Overstimulated nerve cells may die. It says an elevated ratio is not specific for a particular medical condition and is commonly associated with excessive inflammation due to recurrent infections. It does offer some suggestions (deprenyl, melatonin, carnitine,turmeric/curcumin, garlic).

 

Had this test done 2.5 years ago when she was on a combo of abx for lyme/bart and the only thing flagged at that time was the Arabinose (70) and Phenylactic . She was doing good physically at the time. We've been dealing with GI issues & heaaches since 2009. The only time we didn't have headaches & GI issues was the year she was on the combo.

 

I haven't used Custom Probiotcs in a while. I think I'll add that to our mix.

 

Thanks for the links!

Edited May 11, 2013 by philamom

[SSS]

Philamom, you are not going to like me, but

you also did a metamatrix stool test on your dd

that came back gliadin HIGH - red flag-

also on this OAT I looked at this morning,

it indicated inflammation/and said possible celiac disease.

I really, really think she needs to go 100% gluten free.

If there is an intolerance, or god forbid celiac,

it can wreak havoc and completely inflame.

I know it sux- because I had to do it with my dd years ago,

and I also had to go gluten free- I tried adding gluten back after Lyme treatment, and couldn't do it- still GF.

Give it a trial for 3 months.

It must be done 100%, no slips or cheats.

There are a lot of GF foods to choose from now in the grocery store.

You may also want to test for Cealic disease.

[philamom]

I still like you :-)

We did run tests after the Metametrix stool test which all came back negative for celiac. It was done through Quest/Lapcorp, so doubt it would show a sensitivity or intolerance -just if you have the disease.

My daughter is a VERY finicky eater though. On the thin side and rarely hungry. blah blah blah - I know - I should just do it.

I wonder why her GI symptoms went away on the combo of abx. Do you think inflammation from the lyme/bart causes sensitivity to gluten/casein, etc?

[SSS]

I don't know if infections increases the odds of having a gluten intolerance, but wheat itself has changed dramatically, through

hybridization, and adding gliadin to it-

the increase to folks intolerant to wheat and/or celiac disease is staggering.

It sounds like your dd might have a 'leaky gut'

which can happen from overgrowth of yeast/ fungus, poking holes in the intestines,

and then certain food proteins (like gluten, casein) leak into the blood stream, and

can cause autoimmune reactions/ inflammation.

 

When my dd was 4, before any type of medical or immune system issues hit our radar, before any antibiotics, etc.

She was in preschool with selective mutism. She had a horrific temper at home- and ate NO meat or protein whatsoever-

she ate only carbs and fruit. Truckloads of it. That's IT. No milk.

I decided to do 100% GF and CF. Cold turkey.

Red hot rage, would not eat for 1 1/2 days. I held my ground, had shopped GF with plenty to offer.

Then, she started to eat the GF/CF things I put in front of her- protein! I couldn't believe it.

I never told the preschool (brought her own snacks in)

Within weeks, I realized her eyes were NOT dialated- I never knew they were dialated before!

But the preschool- they came to me 6 weeks into it (we were 100% GF/CF)

and said: What have you done?! She is talking! She is engaging! She is involved!

What I had done was reduce inflammation.

I then figured out she had real gut dysbiosis, with major yeast overgrowth (again, before any antibiotics)

I did have her tested for celiac, it was negative.

 

Here is my opinion, FWIW:

You have spent a lot of money on a metamatrix test and an OAT test, looking for something.

I think what it is telling you is she has a gluten intolerance, causing inflammation.

The HIGH gliadin on the metamatrix is not saying HIGH because she is consuming it.

It is saying HIGH because she is reacting to it.

 

You can always just give it a 100% try for 3 months, and see what happens. You can always go back.

[philamom]

Thank you - I really appreciate your opinion S&S.

 

Happy Mothers Day! (and to all you great Moms here)