Glutathione

[Claire]

I just signed up for the ASD_solutions board that Kim pointed me to...

 

They auto-sent me something on glutathione. So I pulled in an excerpt below. You know that I think many of our kids have low glutathione...this is definitely the case in the autism community, and it was a standard part of the DAN protocol for mercury chelation the last time that I looked. We did (do) this instead of chelation.

 

The test for this is usually the Great Plains OAT test...

 

Transdermal is better absorbed than oral... (kirkman labs has it)

 

Claire

 

 

There is evidence that

glutathione depletion can lead to neurological

damage; low levels of glutathione have been found

in Parkinson’s disease and cerebral ischemiareperfusion

injury.29

Glutathione, as both a carrier of mercury

and an antioxidant, has three specific roles in protecting

the body from mercury toxicity. First, glutathione,

specifically binding with methylmercury,

forms a complex that prevents mercury from binding

to cellular proteins and causing damage to both

enzymes and tissue.30 Glutathione-mercury complexes

also reduce intracellular damage by preventing

mercury from entering tissue cells and

becoming an intracellular toxin.

Second, glutathione-mercury complexes

have been found in the liver, kidney, and brain,

and appear to be the primary form in which mercury

is transported and eliminated from the body.24

The transport mechanism is unclear, but complexes

of glutathione and mercury are the predominant

form of mercury in both the bile and the

urine.31 Glutathione and cysteine, acting as carriers

of mercury, actually appear to control the rate

of mercury efflux into bile; the rate of mercury

secretion in bile appears to be independent of actual

bile flow. When bile flow rate is increased or

decreased, the content of mercury in the bile

changes inversely so net mercury efflux from the

liver remains unchanged.32 However, increasing

bile levels of both glutathione and cysteine increases

the biliary secretion of methylmercury in

rats.13 Other studies have confirmed this data in

animal models.33-35 Conversely, glutathione depletion

inhibits biliary secretion of methylmercury

in animal models and blocking glutathione production

appears to shut down biliary release of

mercury.35

Cells of the blood-brain barrier (brain capillary

endothelial cells) release mercury in a glutathione

complex. Inhibiting glutathione production

in these cells inhibits their ability to release mercury.

23 Mercury accumulates in the central nervous

system primarily in astrocytes, the cells that provide

the first line of defense for the central nervous

system against toxic compounds.36 Astrocytes

are the first cells in brain tissue to encounter metals

crossing the blood-brain barrier. They also

contain high levels of metallothionein and glutathione,

both carriers for heavy metals. It is hypothesized

that astrocytes are the main depot of

mercury in the brain.37 In studies with astrocytes,

the addition of glutathione, glutathione stimulators,

or glutathione precursors significantly enhances

the release of mercury from these cells in

a complex with glutathione. Fujiyama et al38 also

suggest that conjugation with glutathione is the

major pathway for mercury efflux from astrocytes.

Glutathione also increases mercury elimination

from renal tissue. Studies in mammalian renal cells

reveal glutathione is 50 percent as effective as the

chelating agent DMSA (2,3-dimercaptosuccinic

acid) in preventing inorganic mercury accumulation

in renal cells.39

Third, glutathione increases the antioxidant

capacity of the cell, providing a defense

against hydrogen peroxide, singlet oxygen, hydroxyl

radicals, and lipid peroxides produced by

mercury.30 The addition of glutathione to cell cultures

exposed to methylmercury also prevented

the reduction of cellular levels of glutathione peroxidase,

a crucial antioxidant enzyme necessary

for protection against the damaging effects of lipid

peroxidation.30

As an antioxidant, glutathione appears to

protect against renal damage resulting from inorganic

mercury toxicity. The co-incubation of rat

renal cells with glutathione and inorganic mercury

was significantly more protective of renal cell injury

when compared to inorganic mercury exposure

alone.40 Antioxidant levels – specifically glutathione,

vitamin E, and ascorbic acid – are depleted

in renal tissue exposed to mercuric chloride

(inorganic mercury), and the addition of glutathione

increased levels of both vitamin E and

ascorbic acid in renal cells exposed to mercuric

chloride.24

Mammalian cell lines resistant to mercury

toxicity have been cloned.41 They do not readily

accumulate mercury and are resistant to the toxic

effects of methylmercury or inorganic mercury.

An outstanding characteristic of this cell line is

that glutathione levels are five times greater in

these cells than the parent cells from which they

originated. The authors of this study conclude that

the mechanisms of resistance were primarily due

to glutathione’s ability to facilitate mercury efflux

from cells and the protective binding of mercury

by glutathione to prevent cellular damage.

[kim]

When researching DHEA I noticed an article that said that glutithione was needed to convert DHEA to DHEA-S.

 

Will delete this part of post, since it's OT

 

If you're still here Claire,

 

Wanted to say that the fact that your son no longer tics, by improving his glut. status along with other things that the MT promotion probably corrected, might we expect to see good ratio's of corisol to DHEA at this point? I wonder what Carolyn's tic status was/is when her test was done, which was a saliva test showing normal levels also.

 

I have suspected destruction of my youngest sons protein digesting enzymes for quite some time, and have suspected sulfer pathway problems for both. The sulfer form of DHEA is just kind of hard to ignore. He does improve with Peptizyde (in regards to protein).

 

With all of the talk of mercury/glutathione and renal function, I can't help but to think of the commercials advertising "good nites" for all of the kids that wet the bed. I wonder if there has been an increase in the incidence of that too?

 

Editing to save you from posting that you're son's tics were eliminated with the removal of screens, right?

And that was prior to MT promotion, I believe. Were you doing anything at the point where the tics were eliminated to increase gluathione? I'm thinking a little more clearly, than the last time we chatted!

 

Kim

[Claire]

Hi Kim,

 

Pfeiffer has deleted most of what was on their website, but I found some excerpts (below), including ..."The primary finding was that 499 of the 503 subjects exhibitedevidence of a metallothionein (MT) disorder. "

 

Also, Pfeiffer doing formal clinical trials on MT promotion now, which to me is a good indicator that they think it is working. I haven't been to a clinic in 1.5 years, so I wanted to see if things had changed. We just got approval to start MT promotion in January 2006, because it took that long to raise my son's zinc to acceptable levels.

 

Anyway, yes, screens was 100% of my son's trigger, and 3 years ago November 2003 (age 10) was his last episode. However, after 2 years of no screens (from ages 8 to 10) showed that he was still reacting to them when we tested it ever 6 months or so. So really it has been 5 years since we solved the tic problem from a trigger standpoint, but we didn't start treating his photosensitivity/underlying immune issues until January 2004. Then in June 2004 (~6 months) he 'passed' a movie screen trigger test...though he was a little fidgety afterwards, but no tic. Now he isn't even fidgety afterward. At school he occasionally gets CRT screen exposure with no issues, but we still do just LCD screens though, but he moved from being able to go 15-30 minutes back then to way more than he should (some days all day) with no issues.

 

Anyway, to answer your question: We ID'd his low glutathione in early 2004 and supplemented orally for many months and it didn't his improve his glutathione levels to normal. They went up a small amount, and maybe that amount helped, but we were supplementing other antioxidants that he was also deficient in, plus supplementing melatonin for a few months, which brought his sleep cycle back to normal, which is a very powerful antioxidant. He was trigger-free/symptom free BEFORE we moved to the dermal glutathione, and his mercury levels appeared to be improved too (from hair and blood tests). Plus vitamin supplementation of deficient vitamins, and removal of certain foods.

 

So we did too much to know for sure what brought his immune system to a satisfactory level, but I am personally convinced that the antioxidants were key. Of course, this coming urine test is scary to see what is left.

 

It is tough to know what (if anything) MT promotion is doing for either of us! We both still have yeast issues, but Pfeiffer does say that these still need to be treated. I guess I am hoping that if the France porphyrin test still shows mercury/lead, that the combo of glutathione and MT promotion will help. Glutathione isn't supposed to really help lead removal from what I read, just mercury, arsenic and cadmium.

 

Sorry if I wasn't clear, but his DHEA/Cortisol ratio always showed normal on these tests. What isn't/wasn't normal was his hyperinsulinism/pancreatic enzymes/blood sugar levels. I am assuming that chronic yeast is a contributor there. But I am going to start researching this area for new information since I last looked. We did and still do vitamin C, pantothenic acid and chromium for it...maybe I cut back too much on those vitamins.

 

Ok, gotta run...I have a HUGE project that is starting...so I may be checking in less often for a while...though I will post what I learn from the mercury urine test. Thanks again!

 

Claire

 

 

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EXCERPTTS FROM THE PFEIFFER SITE--some of this is data that was posted long ago...Claire

We’ve now seen about 16,000 pa-tients and have conducted several out-come studies.

 

They indicate successrates for young, compliant patients to be about

90% for behavior,

85% for depres-sion,

80% for many types of learningdisabilities, and

75% for ADHD.

 

chemistry data on 3,000 adults with clini-cal depression. Some depressed patients have a genetic pyrrole disorder that renders themgrossly depleted in vitamin B6. These in-dividuals cannot efficiently create sero-tonin since B6 is an important cofactor inthe last step of its synthesis. Many ofthese people report benefits from Prozac,Paxil, Zoloft or other serotonin-enhanc-ing medications. However, similar ben-efits may also be achieved by simply giv-ing these patients sufficient amounts ofB6along with augmenting nutrients.We have separated them into five ma-jor chemical categories:Hypercupremia (elevated copper) Thiscondition is especially prevalent inwomen who experience postpartum andother forms of hormonal depression. Wehave very high success here. Treatmentfocuses on promoting the metallo-thionein protein system to achieve agood balance of trace metals.

 

Under-methylated (high histamine)These patients often have addictive orobsessive-compulsive perfectionism.They tend to have allergy and seasonalonset of depression.

 

 

 

Over-methylation These patients usu-ally exhibit a nasty combination of anxi-ety and depression, and are prone topanic attacks. Treatment centers on nu-trient therapy aimed at reducing dopam-ine and norepinephrine levels.Toxicity A small percentage of depressivepatients exhibit heavy-metal or organic tox-icity as their primary chemical imbalance.

 

Pyrrole disorders This chemical imbal-ance is associated with depression, high-anxiety and poor stress control. It in-volves a severe deficiency of B6, whichis a cofactor for serotonin. These patientsMetallothionein (MT)ProteinMT is a family of short, linear,cysteine-rich proteins composed of61 to 68 amino acids. Very versatile,MT proteins are involved in manyimportant functions in humans,including detoxification of heavymetals, immune function, develop-ment of brain cells and synapticconnections, and regulation ofcopper and zinc levels. In studyingmore than 1,200 published articleson MT proteins, we learned thatvirtually all of the classic features ofautism could have resulted fromdisabled or defective MT.The MT protein family is composedof four primary types:MT I and II exist throughout thebody, with high concentrations foundin brain, liver, and intestinal mucosa.MT III is found mainly in the brain,where it has a primary role inneuronal growth inhibition andapoptosis. Recent studies haveshown low levels of MT III in thebrains of Alzheimer’s patients.MT IVMT IV is found primarily in theepithelia of skin and upper G.I. tract.Some of our studies yielded badnews. For example, most Down syn-drome kids have crazy chemistry levels.We expected balancing their chemistrywould help them. It was a complete zero.If they were depressed we could makethem happier.If they were hyperactive wecould make them calmer. But we couldn’timprove the retardation. That was a tre-mendous disappointment.Another disappointment was an out-come study for Obsessive-CompulsiveDisorder (OCD).We’d had some successwith patients who claimed to be com-pletely free of OCD with our therapy. Mosthad high blood histamine, a marker forunder-methylation (see side-bar page 13)and low levels of catecholamines. Butwhen we did the statistics we found thatonly one out of six OCD patients im-proved significantly.Interestingly, we’ve had good suc-cess, about 65%, with people who haveobsessive-compulsive tendencies, not afull expression of the condition.How do you measure success?Our outcome data are obtained in in-terviews with parents and teachers. Ourmost recent study involved 207 consecu-tive behavior cases over a select timeframe. That’s called a “census sample.”We tracked down families and used stan-dardized measurements of behaviors toobtain the data. The results show that11% of our patients did not initiate treat-ment, and a total of 23% became totallynon-compliant within eight months.However, 91% of the compliant pa-tients exhibited fewer assaults and de-structive behaviors, with half reporting acomplete remission of these behaviors.These findings were reported at theAmerican Psychiatric Association. A for-mal paper is being prepared for the jour-nal Physiology and Behavior.In 1992 we began accepting casesof depression and measured an improve-ment rate of 85% of the patients after thefirst year.We can help most victims of de-pression, but not all. We have extensiveWe believe Tourette syndrome isnot a single condition. The indi-vidual phenotypes may requirecompletely different treatmentapproaches.www.Latitudes.org

 

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Page 5

 

said they weren’t aware of such a corre-lation but they would look into it. A fewyears later I received a letter stating theyalso found a high incidence of Ritalin dur-ing TS onset, but didn’t know if it was realor coincidence.They suggested these pa-tients might have developed TS anywayand the Ritalin just triggered it. We’veseen hundreds of kids who took Ritalinand had to stop because they developedfacial or shoulder tics. Nowadays, I thinkmost physicians monitor the possible de-velopment of tics when prescribing stimu-lant medication.I know you have exciting results basedon a recent study on autism at theHealth Research Institute.We believe we may have discoveredthe primary cause of autism. In June2000, we created a database of lab chem-istries for 503 autism-spectrum patientswho had been evaluated at the PfeifferTreatment Center. Between 95 and 160separate analyses of blood, urine, andscalp hair were evaluated for each pa-tient. The primary finding was that 499 ofthe 503 subjects exhibited evidence of ametallothionein (MT) disorder. Copper/zinc ratios were extremely high — rang-ing from 1.5 to 2.5 in most cases — com-pared to a normal value of about 1.0.In May 2000, we reported this work atthe annual meeting of the American Psy-chiatric Association. We proposed thatautism is caused by the intersection oftwo factors: (1) a genetic defect that re-sults in impaired MT functioning, and (2)an environmental insult during early de-velopment that disables MT.Wasn’t a copper to zinc ratio imbal-ance in autistics previously reportedin the literature?High copper levels have been men-tioned since the 1970s, but the connec-tion with MT and brain development wasnever understood.An MT-function abnor-mality can cause impaired brain devel-opment and extreme sensitivity to toxicmetals or vaccines. It appears we canexplain every aspect of autism from thissingle disorder. Pick one and I’ll tell youhow impaired MT functioning explains it.How about the fact that autism beginswithin a set time period — usually byage three?MT proteins are directly involved inbrain development. By age three, thebrain has usually matured to the extentthat an environmental insult can nolonger provoke autism in at-risk children.How does this relate to growing con-cerns that some vaccines are caus-ing autism?Until recently, most childhood vac-cines contained a mercury-compoundadditive used as a preservative. Manyexpectant mothers are also given flushots that contain mercury. Children witha genetic MT protein dysfunction wouldbe expected to be hypersensitive tomercury.Also, MT is involved in the develop-ment of the immune system. A dysfunc-tion in MT might well result in hyper-also have symptoms of severe zincdeficiency.I’ve had families dealing with Tourette’ssyndrome (TS) report that they went toyour clinic with varying degrees of suc-cess. What can you tell us about TS?We discourage Tourette syndromepatients from visiting the clinic since out-come studies indicate a treatment suc-cess rate of only 15 percent. While we’vehad a few dramatic successes, most TSpatients do not improve with this treat-ment alone.Having said that, I do have some in-sight into the underlying profiles of TS.Lab results suggest nearly all of them areunder-methylated. They often respond tocesium, a nutrient metal in the same fam-ily as lithium and sodium. In addition,some TS patients are helped by supple-mentation with free-form amino acids.We did a TS study in the late ’70s incooperation with the Chicago TouretteSyndrome Association. We enrolled 24pairs of brothers in the study—one brotherwith TS and the other without it. We foundthree completely different chemical types.One group primarily had coprolalia—thesocially-unacceptable inability to controlspeech. Another group had a high inci-dence of learning disabilities, ADD/ADHD, and dyslexia. Their chemical im-balances were similar to those found inpatients with learning disabilities. Thethird group had peculiar trace-metal pat-terns that were unfamiliar to us.We believe TS is not a single condi-tion. The individual phenotypes may re-quire completely different treatment ap-proaches.

 

 

 

Our data indicates that TS isassociated with under-methylation andresultant low levels of norepinephrine,dopamine and serotonin. The obsessivecompulsive disorder aspect of TS is con-sistent with under-methylation.The most striking result of our studywas discovering that more than half theTS subjects had developed the conditionwhile taking Ritalin.

 

 

 

We may have discovered the primary cause of autism.

 

 

 

In June2000, we created a database of lab chemistries for 503 autism-spectrum patients

 

 

 

. . . Between 95 and 160 separate analyses of blood, urine, and scalp hair were evaluated for each patient.

The primary finding was that 499 of the 503 subjects exhibitedevidence of a metallothionein (MT) disorder. Copper/zinc ratioswere extremely high–ranging from 1.5 to 2.5 in most cases–compared to a normal value of about

 

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herself had a metal-metabolism disor-der. About one out of three autism fami-lies report that the symptoms were evi-dent at birth.What about the fact that autism mostlyaffects boys? And why has the rate ofautism increased so dramatically thatit’s being called an epidemic?

 

About 80 percent of autistic-spectrumpatients are males. Estrogen and proges-terone help promote the body’s produc-tion of metallothionein. As a result, males have less protection against mercury andother environmental insults that may pro-voke autism.Over the past 20 years there’s beena dramatic increase in the incidence ofautism, which is known to be a geneticdisorder. An epidemic of a genetic disor-der is possible only if environmental fac-tors are involved. Many observers be-lieve that the genetic defect results in hy-persensitivity to vaccines, and that theincreased incidence of autism parallelsthe increased number of vaccinationsgiven to children.Some families report success with se-cretin therapy. Does this fit into yourtheory?MT IV (see page 11) is in high con-centration in parietal cells of the stom-ach.

 

An MT dysfunction might be ex-pected to impair the production of stom-ach acid. The acidity of food entering thesmall intestine signals the pancreas tosend secretin, which stimulates the re-lease of carbonate, digestive enzymes,etc., to enable proper digestion. An in-sufficient amount of stomach acid couldresult in a weakened or absent secretinresponse. The metallothionein theory isconsistent with reports of efficacy of se-cretin in some autistics.Assuming that a metal metabolismdisorder is the underlying cause of au-tism, how can this information helpfamilies?

 

Prevention of autism through early sensitivity to the viruses in a vaccine,especially if several vaccines arebundled together like the MMR(measles, mumps, rubella).How does MT functioning relate to the need for some autistics to avoid casein from milk products, and gluten? If MT is not functioning properly, you would predict intolerance and hypersen-sitivity to casein and gluten. The enzymesthat break down these proteins in the small intestine are zinc-dependent. The zinc for these enzymes is delivered by zinc metallothionein. A serious MT dys-function would diminish enzyme activity and the ability to completely break downcasein and gluten.It’s interesting to note that one of thefunctions of MT is to kill candida albicans. An MT dysfunction could explain whyso many autistic kids have a tendencyfor yeast overgrowth.

 

What about the wide range of symp-toms among autistic children?The specific symptoms depend onthe intensity of the insult and the age atwhich it occurred. Insults in-utero andearly infancy generally have a more pro-found impact on brain development thanthose later in childhood when brain or-ganization and development is morecomplete. It’s also possible that the in-sults temporarily shut down MT, and thesymptoms may depend on the stage ofbrain development at that time. For ex-ample, a heavy-metal insult during de-velopment of the speech center couldresult in speech delay. A severe insult atthat time may result in mutism.These environmental insults could beprenatal?

 

 

Using mercury in vac-cines is a bad idea, but allowing preg-nant women to have flu shots with mer-cury stabilizers can be worse. There is clear evidence in the literature that mer-cury goes to the fetus preferentially. Th

 

Over-Methylation

Many people who suffer from anxietyand depression are over-methylated,which results in excessive levels ofdopamine, norepinephrine andserotonin. Typical symptoms mayinclude chemical and food sensitivi-ties, underachievement, upper bodypain, and an adverse reaction toserotonin-enhancing substances suchas Prozac, Paxil, Zoloft, St. John’s wortand SAMe. They have a genetictendency to have depressed levels offolates, niacin and vitamin B12.Biochemical treatment focuses onsupplementing these nutrients. Thesepeople are also overloaded in copperand methionine. Supplements ofthese nutrients must be strictlyavoided.Under-MethylationMany patients with obsessive-compulsive tendencies, oppositional-defiant disorder or seasonal depressionare under-methylated, which isassociated with low serotonin levels.They generally exhibit seasonalallergies, perfectionism, competitive-ness, and other distinctive symptomsand traits. They have a genetictendency to be very depressed inlevels of calcium, magnesium,methionine and vitamin B6, withexcessive levels of folic acid.These under-methylated individu-als may benefit nicely from Paxil,Zoloft and other serotonin-enhancingmedications, although nasty sideeffects are common. A more naturalapproach is to directly correct theunderlying problem using methion-ine, calcium, magnesium and B6.SAMe, St. John’s wort, Kava andinositol are also useful in treatingthese individuals. Many persons withTourette syndrome fall into thisbiochemical category.D

 

ironmental controls, and other steps toenhance G.I. function.Four to six weeks later, we prescribeindividualized nutrient therapy to ad-dress specific biochemical imbalancesand promote MT function. We ask par-ents to send progress reports during thefirst four months of treatment, and rec-ommend a follow-up evaluation and labtesting after four to six months. Compre-hensive follow-up is important so we canadjust dosages for growth and incorpo-rate advanced treatment protocols.Do you use chelation in your clinicwhen treating children? If so, why?

 

We believe that therapy based on promotion of metallothionein is more ef-fective and longer-lasting than chelation.

 

Whereas DMSA (DimercaptosuccinicAcid) can effectively remove mercury,lead, and other toxic metals from the body,it is relatively ineffective at reducing cop-per levels, and does little to protect thepatient from future toxic exposures.MT promotion therapy does it all. Iteliminates toxic metals, removes excesscopper, restores toxic-metal barriers inintestinal mucosa and blood-brain bar-rier, and promotes development of newneuronal connections. We do occasion-ally use clatheration or chelation for pa-tients with especially severe toxic levels.Why is there so much professionaldisagreement over megadoses ofnutrients?Many professionals seem obliviousto genetic differences in metabolism andbiochemistry. Everyone is not the samenutritionally and biochemically.If we carryout a complete biochemical analysis onanyone, we will typically find this personto be unusually low in four to six importantnutrients because of genetics. He or shewould profit from many times the RDA levelfor those nutrients if they only knew whichfew out of the hundreds they were.This same person would also havea genetic tendency to be overloaded incertain nutrients. Overloading nutritionalsupplements can be very harmful. Afterstudying the biochemistry of 10,000 in-dividuals,

 

 

 

I’ve learned that the greatestmischief is usually caused by nutrientsstored in excessive amounts rather thanat depleted levels. The most commonnutrients in overload include copper,iron, folic acid, calcium, methionine, man-ganese, choline and omega-6 fatty ac-ids. Of course, these same nutrients maybe deficient in others.

 

That’s why multiplevitamin/mineral supplements are usually limited in benefits, and may do moreAlthough only 10 percent of our database case histories involve seriousmalabsorption, more than 90 percentof autistics exhibit this problem.

 

There are three primary classes of ab-sorption problems:

 

(1) stomach prob-lems, including excessive or insuffi-cient HCl levels,

 

(2) incomplete di-gestion in the small intestine, and

 

(3)problems at the brush-border of theintestine where most nutrients are ab-sorbed into the portal blood stream.

 

direct analysis for MT in blood, and (3)chemical analysis for copper, zinc, andceruloplasmin in blood.Babies found to be predisposed to autism could be sheltered from exposureto toxic metals, vaccines and other envi-ronmental hazards until three years ofage. In addition, parents would need tolimit the child’s intake of copper and takesteps to avoid zinc depletion. For the more than 500,000 autism-spectrum patients in the U.S., nutrienttherapy to promote metallothionein maybe a very effective therapy.

 

Restoring MTto proper function has the potential of

 

(1)eliminating food allergies,

 

(2) eliminat-ing malabsorption,

 

(3) detoxifying heavymetals,

 

(4) overcoming taste/texture sen-sitivities,

 

(5) achieving homeostatic con-trol of copper and zinc, and

 

(6) reducingthe tendency for yeast overgrowth.

 

Best of all, improving MT function maydramatically improve the child’s ability todevelop new brain cells and synapticconnections. The brain is constantly form-ing new cells, which requires proper metallothionein function that we can ad-dress nutritionally.

 

Ourdatabase indicates that those peoplewith a metallothionein (MT) disorderare especially sensitive to toxic metals,and that over-methylation is associatedwith severe chemical sensitivities. Effec-tive treatment requires a three-stepapproach.

 

I think the combination of MT-promo-tion therapy and behavioral therapieswould make a great marriage. Behavioraltreatments are an effective way to showerthe brain with impulses, which can stimu-late the development of brain cells andnew neuronal connections. However, ef-ficient development of neuronal connec-tions requires good MT functioning. Ifwe can improve that function, then thebehavioral treatments may work dramati-cally faster and more successfully.ACN believes that while TS and OCDare conditions with genetic predispo-sitions, environmental factors deter-mine the onset and severity of thesymptoms to a very great extent—justas you’ve proposed for autism. If weraised the necessary funds, would yoube willing to analyze the data you haveon all the Tourette syndrome patientsin your database?Certainly. That would be most inter-esting and could help identify subtypesof Tourette syndrome. Hopefully, thiswould lead to more effective treatmentsthan currently exist for this disorder.

[Guest]

Kim-my tics are pretty mild, but I would say my tics were probably a bit worse at the time of testing than they are now. Right now there not noticiable to other who don't know what ts is. I had a lot of stress going on at the time for example, the teachers exam. I also was eating the tubs of earth balance soy butter (I'm not now as I'm off of soy and don't crave the butter any longer).

 

 

 

I'm curious about the glutathione. Does anyone know if DAN changed their thoughts about oral & transdermal glutathione? In the DAN paper I have, I believe it only mentions oral glutathione. I will try oral first because when I asked my doctor which one, he said oral for me. I didn't ask his reasoning about that, but will when I see him next cause I am curious as to why he choose that for me versus the transdermal. The transdermal dmps I'm having has glutathione in it, but I was still low.

 

Carolyn

[kim]

Carolyn/Claire,

 

From Amy Yaskow's site.

http://www.autismanswer.com/articles/yasko..._reversing.html

 

Individuals should get more sulfur/glutathione into the system in as many healthy ways as possible. While glutathione cannot be taken orally, it can be taken transdermally and sublingually.

 

A bit on insulin from same page

 

However, glutamate release leads to the release of insulin, which results in decreased glucose levels.

 

Just popped up this morning (ASD Sol.), a parent says they are about to start lipo gluthathione

http://www.brainchildnutritionals.com/Lipo_GSHx.html but she is concerned about yeast. Another parent responds, that while they saw improvements on lipo, they could not control yeast. They got a nebulizer and get glutathione in vails from Wellness now.

 

.

[kim]

I just wanted to add, that I only posted the above link to the lipo glut. site, because I didn't know what it was, and figured a lot of others might not either. The parents discussing this, on the other bd. have Dr.s guiding these treatments, as do Claire, and Carolyn.

[quan_daniel]

Carolyn/Claire,

 

From Amy Yaskow's site.

http://www.autismanswer.com/articles/yasko..._reversing.html

 

Individuals should get more sulfur/glutathione into the system in as many healthy ways as possible. While glutathione cannot be taken orally, it can be taken transdermally and sublingually.

 

A bit on insulin from same page

 

However, glutamate release leads to the release of insulin, which results in decreased glucose levels.

 

Just popped up this morning (ASD Sol.), a parent says they are about to start lipo gluthathione

http://www.brainchildnutritionals.com/Lipo_GSHx.html but she is concerned about yeast. Another parent responds, that while they saw improvements on lipo, they could not control yeast. They got a nebulizer and get glutathione in vails from Wellness now.

 

.

 

 

Kim,

Does TS-PLUS helps with glutathione?

Is your younge child taking it?

 

I remember there is something in TS-PLUS helps with glutathione.

 

Thanks

Daniel

[kim]

Daniel,

 

Yes, TS Plus has L glutathione 12.5 mg. per 10 capsules.

 

My boys are taking such low amounts of the vitamins, that I'm not too concerned as far as yeast control. As Bonnie added vit. D to TS plus recently, maybe she will make other changes in the future, or maybe like Carolyn's Dr. she still feels there is some benefit to it?

But, to answer your question, no, I would not count on the vitamins to raise glut. levels, based on what I have read. However, some of the other elements may help the body to produce it?

 

Kim