When does DNASE rise after strep infection?

[philamom]

My daughter's DNASE is 663. How long after a strep infection would this rise take place? Her last DNASE B in June was <50. It was not drawn in August by mistake.

 

Her ASO is normal at 61. In June it was 35. In August it was 48.

 

-thx

Edited October 5, 2011 by philamom

[eljomom]

I have heard 6-8 weeks, and continues to rise after that. In our case, however, there is no rise after strep. The problem is that you don't know what her "personal rise" will be. Maybe she just had it 6-8 weeks ago, and is just on the rise, or maybe she had it in May, and hadn't risen yet, but has risen and is now dropping. I think you will likely need another one in a few weeks to a month???? Not a doctor, just a mom....

[philamom]

My dd had a sudden increase of symptoms earlier this month, right before school started, that I felt was due to strep. Of course, everyone felt it was due to school, but my gut instinct was telling me otherwise. I took her for a throat swab Sept 11th which was negative but she was on a combo of antibiotics, so wasn't expecting a positve culture anyhow. I knew her increase wasn't due to herxing because we hadn't changed abx or added in any supplements.

 

I guess I'll never know for sure.

[JJMom39]

My ds had a similar situation but right after school started. He was doing really well, then he started showing his tell-tale symptoms. We were not aware of any exposure and his swab was negative. But we check titers every couple of months and his DNASE, which had normalized in June, was elevated again. We treated based on that and the flare up stopped in its tracks. Like you said no way to know what caused the increase--new infection, old infection, exposure....

[philamom]

Yeah...she was on treatment dose of antibiotics for PANDAS & Lyme at the time of the draw. Unfortunately, right now she is on no abx due to elevated LFT's. We will check titers again at the end of the month.

[aidansmom]

I don't really having any help but we are having a similar experience so I don't know if comparing notes would be helpful for either one of us. For Aidan we have these numbers:

in June ASO was 123 and dnase was 165

july ASO was 126 and dnase was 166

Aug ASO was 122 and Dnase was 487

Sept ASO was 138 and dnase was 598

ASO are all in normal range (<150)

 

I think we have had an increase of symptoms but Aidan's baseline behavior is not normal so sometimes it is hard to tell if there is increase in symptoms especiall when it probably started when it was summer and we are out of the routine of going to school it is harder for me to tell if there are any changes. And then there are all of the variables for us - going back to school, herxing, etc. There were a couple of outburts that he had especially in Aug and Sept - maybe even some in June/July and some sleeping issues that I have wondered might be attibuted to strep.

 

IN 2010 his dnase was elevated all year and finally went down beginnning of 2011. I keep wondering if augmentin kept that in check which he went on in Dec and off of in June. He is in lyme treatment and is on multiple antibiotics (ominicef, bactrim and flagyl) that are pulsed (not daily) and he started babesia treatment last week - mepron and artemisnin - also pulsed. I think prior to this they were tageting Bartonella (red spot under eye disapeared after being there for years!) I keep wondering if he needs to go back on augmentin for strep though.

 

We will keep tracking ours and I am sure the LLMD will help us figure out. So far LLMD says (via phone nurse)that dnase is high due to issues with immune system regarding Lyme/coinfections (if I am understanding correctly).

 

Philamom - So you can't do antibiotics at all? Are there more natural treatments that target strep? and would she be able to take them with the elevated LFTs?

Edited October 5, 2011 by aidan'smom

[philamom]

aidan'smom- she's only been off for 10 days. I had her LFT's drawn again on Monday, so waiting for results. I think if they return to her slightly elevated numbers (been like that for 2+ years), then we will slowly add back the antibiotics. If they are still elevated - then I guess I will begin asking for advice on natural ways to treat . I think I remember OLE being thrown out there...but can't recall if it's hard on the liver.

[Christianmom]

Here are my son's ASO/Dnase values. Notice his Dnase was still rising as his ASO was coming down. His Dnase is finally coming down now, but is still high, even though his ASO has been normal for several months.

 

10/2010 235/316

12/2010 171/340

02/2011 147/680

09/2011 132/340