Any experience with Luteolin?

[LNN]

I also posted this on the Pandas forum...

So I am at war with cytokines and have been searching for anti-inflammatory options other than ibuprofen or naproxen (Aleve). My theory is that when we attack lyme too aggressively, the release of toxins triggers a cytokine storm and autoimmune/Pitands response. The cure is as bad as the disease itself. So we're between a rock and a hard place. Tomorrow we head to the LLMD. The goal - kill the lyme without triggering Pitands. Considering pulsing abx, looking into metals/oral chelation, binding agents, and I need some way to squash inflammation. I came across these threads and was wondering if anyone had any experience with luteolin...

 

http://www.raysahelian.com/luteolin.html

Luteolin exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. It also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells.

 

Luteolin and brain inflammation

University of Illinois researchers report lutelin, found in celery and green peppers, can disrupt a component of the inflammatory response in the brain. Rodney Johnson of the University of Illinois at Urbana-Champaign and graduate student Saebyeol Jang found that luteolin inhibits a key pathway in the inflammatory response of microglia -- brain cells key to the body's immune defense. Microglial cells exposed to luteolin show a significantly diminished inflammatory response. Luteolin reduces production of interleukin-6 -- used in cellular communication -- in the inflammatory pathway by as much as 90 percent.

 

My link

Luteolin is a yellow crystalline compound. It is a flavonoid; more specifically, it is one of the more common flavones.[1] From preliminary research, it is thought to play a role in the human body possibly as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune system modulator[citation needed]. If applicable to the human condition, these characteristics may inhibit cancer mechanisms. Basic research results indicate luteolin as an anti-inflammatory agent[2] with other potential effects on septic shock.[citation needed] It has been suggested for multiple sclerosis on the basis of in vitro work.[3]

 

and several pubmed studies (always makes me feel better when I can find these)

http://www.ncbi.nlm.nih.gov/pubmed/21671964

Significance and Impact of the Study:  The findings indicate that luteolin may be used as a basis for development of antimicrobial agents aimed at bacterial virulence factors.

 

http://www.ncbi.nlm.nih.gov/pubmed/21631167

ABSTRACT Microglia activation is one of the causative factors for neuroinflammation, which results in brain damage during neurodegenerative disease. Accumulating evidence has shown that the flavonoid luteolin (Lut) possesses potent anti-inflammatory properties; however, its effect on microglia inhibition is currently unknown. Moreover, it is not clear whether Lut also has indirect neuroprotective effects by reducing inflammatory mediators and suppressing microglia activation. In this study, we examined the effects of Lut on lipopolysaccharide (LPS)-induced proinflammatory mediator production and signaling pathways in murine BV2 microglia. In addition, we cocultured microglia and neurons to observe the indirect neuroprotective effects of Lut. Lut inhibited the LPS-stimulated expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β) as well as the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)). Moreover, Lut blocked LPS-induced nuclear factor kappa B (NF-κ activation. Preincubation of microglia with Lut diminished the neurotoxic effects, owing to the direct anti-inflammatory effects of the compound. Taken together, our findings suggest that Lut may have a potential therapeutic application in the treatment of neuroinflammatory disorders.

 

There's a site that sells the stuff as a lozenge or a powder - but I'm always hesitant to make my kids guinea pigs.

http://www.luteolin.com/

 

Anyone have any thoughts, pro or con? Will also post on the lyme forum...Any input appreciated.

Laura

[911RN]

I also posted this on the Pandas forum...

So I am at war with cytokines and have been searching for anti-inflammatory options other than ibuprofen or naproxen (Aleve). My theory is that when we attack lyme too aggressively, the release of toxins triggers a cytokine storm and autoimmune/Pitands response. The cure is as bad as the disease itself. So we're between a rock and a hard place. Tomorrow we head to the LLMD. The goal - kill the lyme without triggering Pitands. Considering pulsing abx, looking into metals/oral chelation, binding agents, and I need some way to squash inflammation. I came across these threads and was wondering if anyone had any experience with luteolin...

 

http://www.raysahelian.com/luteolin.html

Luteolin exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. It also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells.

 

Luteolin and brain inflammation

University of Illinois researchers report lutelin, found in celery and green peppers, can disrupt a component of the inflammatory response in the brain. Rodney Johnson of the University of Illinois at Urbana-Champaign and graduate student Saebyeol Jang found that luteolin inhibits a key pathway in the inflammatory response of microglia -- brain cells key to the body's immune defense. Microglial cells exposed to luteolin show a significantly diminished inflammatory response. Luteolin reduces production of interleukin-6 -- used in cellular communication -- in the inflammatory pathway by as much as 90 percent.

 

My link

Luteolin is a yellow crystalline compound. It is a flavonoid; more specifically, it is one of the more common flavones.[1] From preliminary research, it is thought to play a role in the human body possibly as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune system modulator[citation needed]. If applicable to the human condition, these characteristics may inhibit cancer mechanisms. Basic research results indicate luteolin as an anti-inflammatory agent[2] with other potential effects on septic shock.[citation needed] It has been suggested for multiple sclerosis on the basis of in vitro work.[3]

 

and several pubmed studies (always makes me feel better when I can find these)

http://www.ncbi.nlm.nih.gov/pubmed/21671964

Significance and Impact of the Study:  The findings indicate that luteolin may be used as a basis for development of antimicrobial agents aimed at bacterial virulence factors.

 

http://www.ncbi.nlm.nih.gov/pubmed/21631167

ABSTRACT Microglia activation is one of the causative factors for neuroinflammation, which results in brain damage during neurodegenerative disease. Accumulating evidence has shown that the flavonoid luteolin (Lut) possesses potent anti-inflammatory properties; however, its effect on microglia inhibition is currently unknown. Moreover, it is not clear whether Lut also has indirect neuroprotective effects by reducing inflammatory mediators and suppressing microglia activation. In this study, we examined the effects of Lut on lipopolysaccharide (LPS)-induced proinflammatory mediator production and signaling pathways in murine BV2 microglia. In addition, we cocultured microglia and neurons to observe the indirect neuroprotective effects of Lut. Lut inhibited the LPS-stimulated expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β) as well as the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)). Moreover, Lut blocked LPS-induced nuclear factor kappa B (NF-κ activation. Preincubation of microglia with Lut diminished the neurotoxic effects, owing to the direct anti-inflammatory effects of the compound. Taken together, our findings suggest that Lut may have a potential therapeutic application in the treatment of neuroinflammatory disorders.

 

There's a site that sells the stuff as a lozenge or a powder - but I'm always hesitant to make my kids guinea pigs.

http://www.luteolin.com/

 

Anyone have any thoughts, pro or con? Will also post on the lyme forum...Any input appreciated.

Laura

 

 

 

I just did alot of research on this last night- the Lutimax site has lots of links to research articles as does just googling Lutimax, Luteolin. My drawback is it states that kids do better on this is if on a low carb diet- lots of proteins needed?? If my son gave up carbs....he would not eat much at all. Very OCD on food choices. One Mom on NIDS forum...I think?? said her child completely stopped visual stimming once on Lutimax. That is not a particular problems for us but I thought it was interesting. She said her child did it badly and continuously and poof- gone- with Lutimax??

 

Have never tried it but it does look promising... we just can't do the low carb part of it.

[Fixit]

Laura, did you eventually try this?

what where your results?

have you come in contact with other parents that had benefitted from this?

 

my DAN has mentioned it a couple times...thinking of adding it.

it also says it can be found in peppermint.

i was researching and ordered some peppermint recently as ds says he feels calmer and has less of a feeling to tic for a period after comsuming peppermint.

peppermint is frequently used for digestion.

i hope this can be a major key to ds' recovery...though i hope others might benefit too, i would like it to be our turn

 

thanks

[hugs2day]

I don't know about Luteolin but I have read many times that celery reduces brain inflammation. I juice celery and kale into my sons pasta sauce. It's probably not big enough of a dose to bring on substantial healing but my husband and I make every effort in hopes it will all add up.

 

LLM you mentioned celery extract. I would be very interested in that, please share if your doctor can shed some more light on that supplement. Thank you.

[LNN]

Fixit - I never tried Luteolin. S&S posted about a negative response for her DD and two weeks after this thread, we tested and found pyroluria. Treating the pyroluria was really the key for my son, so I never had the need to go back and consider luteolin again. Not to say it isn't worth trying, but we just didn't need to go there.

 

Hugs - never pursued the celery seed either. We were in a phase where we were sort of treading water - making progress, hitting walls, taking steps backward, then a little forward. So I did a shotgun type of research, hunting around for ideas. Once we found the pyroluria, everything else was put on a shelf.