latest on IgG

[ibcdbwc]

I've read some discussion from 2009 on the signif of failed immunity after Prevnar. Buster's position in 2009 was that you can't really know if its signif. unless you vaccinate again and re=test the response. I am wondering what is the latest position on this? We just now got our lab tests back and "failed" 6/7 Pneumococcal antibody titers. After reading Buster's position I'm not sure this finding really matters at all.

 

We also have "moderate IG 2 subclass deficiency" and "significant IG 3 subclass def." I've read that IG subclass 2 is most common in children and IG subclass 3 is most common in adults. I think I remember reading that a high percentage of people are "deficient," but I can't track down that figure again. So again, I question the actual signif. here. Other than to say it correlates with a history of frequent infections. Also, low normal Ig E. And I believe an allergy component.

 

What is the latest in terms of the statistical signif. with these tests? I've been to the links suggested by PANDAS NETWORK and can't find anything past 2009.

[philamom]

You may be able to receive insurance coverage for IVIG if you have a deficiency (if that's the direction you're headed).

[ShaesMom]

I'm probably involved in a lot of those discussions from 2009 as my dd was one of the first to be dx'd with low Pneumo titers and receive a dx of a PIDD based on those results. The exact name is Selective Antibody Deficiency.

 

The significance really depends on your Immunologist. There is a difference of opinions among this group of Doctors as to whether or not this is a true Immune Deficiency that should be treated with Ivig. Our Immunologist believes strongly that it is a PIDD and has been treating my dd with Ivig every 4 weeks for the last two years.

 

Buster is correct-the standard protocol is to revacinate with Pneumovax and retest the titers a few weeks later. The problem with this test is some people will hold the titers for a few weeks but six to twelve months down the road they may be close to zero again.

 

A good immunologist will look at all the test results and the patients health history to determine whether or not Ivig is warranted.

 

You can learn more about it at www.primaryimmune.org Click on the link to the Publications & then Patient & Parent Handbook. chapters 1,2 & I believe 10. 10 may not be correct-look for the chapter title Subclass deficiency (this will address subclass 2 & 3 deficiency)