Peripheral NS

[peglem]

So with all this talk about the BBB and closing it, and how to get the auto-antibodies to go away- and do the receptors themselves act like antigen to trigger antibody production....

 

My understanding is that the same receptors found in the basal ganglia are also found in the peripheral nervous system...so, I'm wondering (this probably isn't great for my sanity) if you have motor/autonomic dysfunction caused by PANDAS that is not related to the basal ganglia malfunctioning?

 

What got me thinking about this is that my daughter was on bethanechol to treat problems with her sympathetic/parasympathetic nervous system. It worked great! But, in November, she started having episodes of profuse, shirt soaking sweats. I looked up SEs to her various meds and found that it was a possible side effect of bethanechol. She's been on it for a couple of years, at least and we never had this problem before, but it resolved when we removed the bethanechol. My thinking is that as we continue PANDAS treatment, the issue that was causing the original symptoms that the bethanechol was treating is being resolved and now the med is causing SEs, instead of treating the symptoms which are no longer there. To my knowledge bethanechol does not cross the BBB and so it was not treating anything in the basal ganglia. Although, I suppose the sympathetic problems could have been the result of basal ganglia dysfunction-downstream in the chain.

[Fixit]

So with all this talk about the BBB and closing it, and how to get the auto-antibodies to go away- and do the receptors themselves act like antigen to trigger antibody production....

 

My understanding is that the same receptors found in the basal ganglia are also found in the peripheral nervous system...so, I'm wondering (this probably isn't great for my sanity) if you have motor/autonomic dysfunction caused by PANDAS that is not related to the basal ganglia malfunctioning?

 

What got me thinking about this is that my daughter was on bethanechol to treat problems with her sympathetic/parasympathetic nervous system. It worked great! But, in November, she started having episodes of profuse, shirt soaking sweats. I looked up SEs to her various meds and found that it was a possible side effect of bethanechol. She's been on it for a couple of years, at least and we never had this problem before, but it resolved when we removed the bethanechol. My thinking is that as we continue PANDAS treatment, the issue that was causing the original symptoms that the bethanechol was treating is being resolved and now the med is causing SEs, instead of treating the symptoms which are no longer there. To my knowledge bethanechol does not cross the BBB and so it was not treating anything in the basal ganglia. Although, I suppose the sympathetic problems could have been the result of basal ganglia dysfunction-downstream in the chain.

 

i'm not as advanced as you....

but isn't that why some get relief for tics with mag or b vits...it works on the peripheral nervous system..somewhere down the chain...

those supplements would not be doing anything in the basal ganglia or over the bb...

or am i still not connecting the dots???

[peglem]

So with all this talk about the BBB and closing it, and how to get the auto-antibodies to go away- and do the receptors themselves act like antigen to trigger antibody production....

 

My understanding is that the same receptors found in the basal ganglia are also found in the peripheral nervous system...so, I'm wondering (this probably isn't great for my sanity) if you have motor/autonomic dysfunction caused by PANDAS that is not related to the basal ganglia malfunctioning?

 

What got me thinking about this is that my daughter was on bethanechol to treat problems with her sympathetic/parasympathetic nervous system. It worked great! But, in November, she started having episodes of profuse, shirt soaking sweats. I looked up SEs to her various meds and found that it was a possible side effect of bethanechol. She's been on it for a couple of years, at least and we never had this problem before, but it resolved when we removed the bethanechol. My thinking is that as we continue PANDAS treatment, the issue that was causing the original symptoms that the bethanechol was treating is being resolved and now the med is causing SEs, instead of treating the symptoms which are no longer there. To my knowledge bethanechol does not cross the BBB and so it was not treating anything in the basal ganglia. Although, I suppose the sympathetic problems could have been the result of basal ganglia dysfunction-downstream in the chain.

 

i'm not as advanced as you....

but isn't that why some get relief for tics with mag or b vits...it works on the peripheral nervous system..somewhere down the chain...

those supplements would not be doing anything in the basal ganglia or over the bb...

or am i still not connecting the dots???

I don't know...I can't even find all the dang dots!