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Hitman -- Remind me where you're located...in the States? Somewhere abroad? I suspect that the dose of and composition of the amoxicillin you've been given is going to fall short in terms of desired mental impacts. Not only is the dosage low, but straight amoxicillin lacks the clavulanic acid adjunct that Augmentin includes (amoxicillin plus clav acid), and there has been research regarding the mental benefits of clav acid. Some PANDAS kids here (mine included) benefitted greatly from Augmentin 875 mg. or, even more so in our case, Augmentin XR which is an extended release formulation which comes in 1,000 mg. tablets. The advantage of the XR may be that it stays active in the system longer given that cellulose component which allows it to distribute more slowly, but if I recall correctly, the straight Augmentin 875 mg. contains a higher clav acid component, which might be why your consult suggested this. I know there's a thread or two here on the forum regarding this, so you might run a search for "clav acid" or something along those lines and see what you find. As for the gastro-intestinal impacts, yes, I think those will fade over time as your body adjusts to the addition of the abx. I would add a probiotic or two, if you haven't already, to help repopulate your gut flora and keep things from getting off-kilter there. This might be another vote for the XR formulation, too, since the entire dose won't hit your system at once. In terms of feeling the effects/impacts, it really does vary. My son was entirely non-functional at the point that we finally got access to abx for him, and he was markedly improved within 48 hours of his first dose; however, again, he started at such an incredibly low point, almost anything would have been an improvement at the time. In his case, return to full, up-to-speed cognitive function was a longer, slower process (sorry); the lift of the brain fog, improvement in executive functioning, return of clear "normal" speech patterns, etc. were a slow, gradual result. In his case, I attribute that to the duration of time for which he suffered before we got meaningful help and the need for the inflammation to be halted and reduced, healing of the blood brain barrier (BBB), etc. Why I think it likely that, given the right abx at the right dose, you are likely to "feel" better within a relatively short period of time (mood lifting), I suspect it will take a little longer for the brain fog to clear and your cognition to return in full. Sorry you're dealing with this but I wish you a speedy recovery!