N acetylglucosamine

[kim]

http://www.nature.com/nm/journal/v1/n3/abs/nm0395-237.html

Glycosylation changes of IgG associated with rheumatooid arthritis can activate complement via the mannose-binding protein

 

http://www3.interscience.wiley.com/journal...470730/abstract

Detection of immunoglobulin G glycosylation changes in patients with rheumatoid arthritis by means of isoelectric focusing and lectin-affinoblotting

 

http://www3.interscience.wiley.com/journal...=1&SRETRY=0

Distinct oligosaccharide content of rheumatoid arthritis-derived immune complexes

[P_Mom]

Kim....dr.K has suggested the use of NAG to some children.

[kim]

Does anyone who has been using NAG have an update?

 

Kelly, do you know why Dr.K is recommending it? Is it in families with a history of RA or anything else in particular?

 

 

 

I found this yesterday and wanted to leave it here. I have a way of crashing computers and losing my saved info. so I'm trying to keep more on the forum.

What I think is significant here, is that IVIG has been found to be beneficial because it provides immune molecules that express sialic acid. If there is a problem in with the expresson of UDP N-acetylglucosamine, might this be part of the problem?

 

 

http://www.weizmann.ac.il/molgen/members/l...netics-HIBM.pdf

 

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine

kinase has been shown to be the rate-limiting

enzyme in the sialic acid biosynthetic pathway1

[bronxmom2]

Hi Kim, we are still using it, but my son's away visiting his dad right now so I'm not sure if it's doing anything.

I can say for certain that it didn't hurt, so it's still part of our regiment.

 

I'll let you know when we get him back next week.

 

Another thing that was interesting from our discussion last fall was the idea of raw (unpasteurized) milk giving immune benefits similar to breast milk. I am trying to find a good co-op where I can get raw milk in NYC to give my PANDAS and my 22 mo who I am still nursing.

[sf_mom]

I just wanted to say....I think its fantastic that you are still BFing your 22 month. From everything I have read its the BEST protection. Way to go. Could you pump and mix it with yogurt or something so your old son would drink the breast milk?

 

Hi Kim, we are still using it, but my son's away visiting his dad right now so I'm not sure if it's doing anything.

I can say for certain that it didn't hurt, so it's still part of our regiment.

 

I'll let you know when we get him back next week.

 

Another thing that was interesting from our discussion last fall was the idea of raw (unpasteurized) milk giving immune benefits similar to breast milk. I am trying to find a good co-op where I can get raw milk in NYC to give my PANDAS and my 22 mo who I am still nursing.

[kim]

Thanks for the response bronxsmom. Would really appreciate any observations regarding the NAG.

 

In regards to BFing, couldn't agree with SF mom more.

 

Thought you might find this interesting. This is well known, it's just not well publicized. Why might that be...... Seems with all of the concern about the well being of children, right down to the BILLIONS and BILLIONS spent on vaccination, this would be in our face constantly, you know, like the importance of a properly installed car seat. WHY would young mothers not be made more aware of such things????? Infant formulas and cow and buffalo milk showed a lower inhibitory activity against pneumococci and enhanced the adhesion of H. influenzae.

 

http://www.jstor.org/pss/30105353

 

 

Abstract

Human milk inhibited the attachment of Streptococcus pneumoniae and Haemophilus influenzae to human pharyngeal or buccal epithelial cells. Infant formulas and cow and buffalo milk showed a lower inhibitory activity against pneumococci and enhanced the adhesion of H. influenzae. The antiadhesive effect against S. pneumoniae was found in both the high- and the low-molecular-weight fractions of milk. The inhibitory activity in the high-molecular-weight fraction was independent of specific antibody content; it was present after immunoadsorption and in the milk from IgA-deficient women. The inhibitory activity in the low-molecular-weight fraction was in part explained by the content of oligosaccharides corresponding to the carbohydrate moieties of the neolactoseries of glycolipids, which have previously been shown to act as receptors for attaching pneumococci. The antiadhesive activity against H. influenzae was restricted to the high-molecular-weight fraction of the milk and was unaffected by immunoadsorption. Milk may protect against otitis by reducing colonization

[kim]

http://www.ncbi.nlm.nih.gov/pubmed/19480828

 

Med Sci (Paris). 2009 May;25(5):473-81.

 

[Anti-glycan antibodies establish an unexpected link between C. albicans and Crohn disease]

[Article in French]

 

Sendid B, Jouault T, Vitse A, Fradin C, Colombel JF, Poulain D.

 

Inserm U, Université Lille, CHRU de Lille, France.

 

Abstract

Almost 80 % of the dry weight of the yeast cell wall is composed of glycans including mannans, glucans and chitin. Within this variable and complex edifice, glycans play a major role in their relation with the environment. Experimental antibodies allowed to define the localization, the variability of expression and the biological role of numerous natural oligosaccharidic sequences. These glycans and their synthetic analogues were used to study the human humoral response during invasive candidiasis (IC) determined by Candida albicans and Crohn's disease (CD) where antibodies against the dietary yeast Saccharomyces cerevisiae have been reported. On these bases, it was established experimentally and clinically that a large panel of CD biomarkers consisting in anti glycans antibodies were also generated during IC establishing a link never suspected between C. albicans and CD. We describe here the principle of this serological analysis and its perspectives related to the use of multianalyte profiling technology for a a better understanding of IC and CD pathophysiology. This may contribute to improve disease management in terms of diagnosis and therapy.

 

 

http://dartmed.dartmouth.edu/spring06/html/disc_cholera.php

 

Why should a defect in a gene that determines attachment to chitin also result in deficient binding to gut epithelium? Although chitin is not found in the gut, Taylor suspected the chitin binding protein was actually linking to a subunit of chitin known as GlcNAc, which is also common in the gut. Thus the same protein could participate in binding to both chitin and gut.

http://www.ncbi.nlm.nih.gov/pubmed/8697640

 

Clin Exp Immunol. 1996 Jul;105(1):79-83.

 

Abstract

We have previously reported the finding of circulating antibodies recognizing two proteins of 100 and 120 kD (PO100 and PO120) from Pityrosporum ovale in patients with psoriasis. These antibodies were specific, since they were not detected in normal sera nor in other diseases linked to P. ovale such as seborrhoeic dermatitis or pityriasis versicolor. The present study aimed at further characterizing the specificity of these antibodies. Enzyme-labelled lectins were used to determine the carbohydrate composition of PO120 and PO100. BSII, a lectin that recognizes terminal N-acetylglucosamine (GlcNAc), showed the same banding pattern as sera from patients.

 

http://www.ncbi.nlm.nih.gov/pubmed/11979041

 

Abstract

Atopic dermatitis is a chronic multifactorial inflammatory skin disease, which has had a marked increase in prevalence during the last decades. Recently, a new nomenclature was recommended where the term 'atopic eczema/dermatitis syndrome' (AEDS) should be used to reflect the heterogeneity in this group of patients and where those patients without measurable IgE reactivity should be classified as either 'nonallergic AEDS' or 'non-IgE-associated allergic AEDS'. For nearly 20 years it has been discussed whether the opportunistic yeast Malassezia, previously designated Pityrosporum, is a contributing factor to AEDS. Today there are several reports that demonstrate specific serum IgE or positive skin prick test and/or atopy patch test reactions to Malassezia in patients with AEDS. Several IgE-binding components have been identified in extracts of Malassezia ranging in molecular mass between 10 and 100 kD.

Can't find any good reference for this but...

 

http://en.wikipedia.org/wiki/Malassezia#ci...e-TTMArchive-14

 

It is hypothesized that individuals with Trichotillomania suffer from a sort of autoimmune-disordered reaction to Malassezia and/or Candida yeast. Since Malassezia is especially present in the hair follicles and scalp, "hair pulling is like sneezing: the body is attempting to rid itself of an allergy-causing irritant." [15]

 

 

further psoriasis/skin stuff connection?

 

http://www.springerlink.com/content/x6380hv01745h5j7/

 

Calmodulin antagonism inhibits human keratinocyte proliferation

 

calmodulin levels are grossly elevated in both lesional and nonlesional epidermis of psoriasis

Edited May 19, 2010 by kim

[Johnsmom]

I just had to share my story about this stuff. I have a bad gut. Its not severe but I have taken a good look at it since starting my kid on the DAN protocol. I also have ketaris pelaris (sp) otherwise known as chicken skin. My DS has it too. I was always told it was an omega 3 deficiency. Of course we have been taking fish oil and probioitcs for several years now. Last year I picked up a bottle of Renew Life's Flora More. I got to the bottom of the bottle and lo and behold I had the most perfect gut I have ever had (not going to get graphic here) On top of that my KP completely dissappeared. I mean it when I say COMPLETELY! My husband could not believe how smooth and soft my arms were. I wondered if it was the fish oil but checked the probiotics bottle to find out what strains were in it. At the bottom was N-ACETYL GLUCOSAMINE 25 mg.

I asked the DAN doctor about why my symptoms improved so greatly and she said that the NAG was too low. We didnt talk much further about it because the appointment wasnt about me of course.

I tried reading up on the stuff but couldnt find a lot of info and the health food store did not carry it at the time. I remember even being on vacation and eating the way you do on vacation and having a perfect gut. When I got home I came down with a cold and then the perfect gut and skin dissappeared and hasnt returned since.

I have been so frustrated since then because while I still take it, it doesnt work anymore. It could very well have been the strains of bacteria but I here the NAG has major gut healing properties.

 

UGH. anyway my kid comes first, then I will figure out myself out

[Johnsmom]

Buster,

 

Was quite excited to read your hypothesis and it's stated much more eloquently than what I usually come up with!

 

This is has a filing date of 11/89, so not sure if newer research refutes any of this. Seems to me that these NAG containing chains have a negative charge. They should repel bacteria in some instance, so if a deficiency is present, could account for more frequent infections i.e. bladder, throat, sinus, lung etc. the "mucousy" membranes? The tone of this suggests that the GAGS are deficient subsequent to infection, bit i wonder if these findings are present to some degree, prior to the infection.

 

http://www.freepatentsonline.com/EP0372730.html

 

The inventor has discovered that sufferers of Crohn's disease have a reduced level of NAG in their system. The inventor has also discovered unexpectedly that an intake of a pharmacologically acceptable amount of NAG stimulates the synthesis of protective substances, improves tissue integrity and restores tissue function in the direction of normal. Administration of NAG in therapeutic quantities has been found to be helpful in the treatment of Crohn's disease. In IBD, specifically, the conversion of glucosamine to NAG has been found to be much slower than normal. This invention, in one aspect, is directed to overcoming IBD to at least a certain extent by supplementing the sufferer's (patient's) diet with NAG.

I also found this statement from the same article really interesting. Some kids who have been taking huge amts of probiotics are still found to have reduced levels of some of the supposed beneficial bacteria's.

 

WHAT INVENTOR??????

 

It is known that NAG is secreted into mother's milk and stimulates the establishment of lactobacilli in the intestine of newborn infants who are breast-fed. Such flora tends to prevent establishment of less favourable bacteria and has certain advantages in the digestion of milk and in proper bowel function. A similar situation exists in vaginitis, where the prevalence of lactobacilli has a similar protective effect. However, establishment of this organism has not heretofore been successful, probably because of the lack of the "growth factor", NAG, which is required by this organism to enable synthesis of the cell wall. Consequently, providing NAG as a dietary supplement represents a physiological means of encouraging the establishment of lactobacilli in the vagina, with the attendant benefits.

[kim]

Johnsmom,

 

Very interesting post. Wondering if anything in this thread is leading you to believe that your problem and your sons may not be entirely seperate issues?

 

I think there was a question in that last post?

 

I also found this statement from the same article really interesting. Some kids who have been taking huge amts of probiotics are still found to have reduced levels of some of the supposed beneficial bacteria's.

 

WHAT INVENTOR??????

 

That is just referring to the inventor listed on the patent

 

http://www.freepatentsonline.com/EP0372730.html

Edited May 20, 2010 by kim

[Johnsmom]

i have a dairy intolerance and so does my son. He is GF/Cf/SF and i am not. i did stop dairy on 2 occasions for about a month and didnt notice any skin changes or gut changes. i have to go back to eliminating it from my diet. With all the stress, i need my occasional pizza or cappucino and biscotti!!!!!!

 

Johnsmom,

 

Very interesting post. Wondering if anything in this thread is leading you to believe that your problem and your sons may not be entirely seperate issues?

 

I think there was a question in that last post?

 

I also found this statement from the same article really interesting. Some kids who have been taking huge amts of probiotics are still found to have reduced levels of some of the supposed beneficial bacteria's.

 

WHAT INVENTOR??????

 

That is just referring to the inventor listed on the patent

 

http://www.freepatentsonline.com/EP0372730.html