Hi jukyardjean, I was googling low SigA and found your post. I am trying to improve my boys (6, 8yo) SigA which has been persistently low for well over a year, despite various treatments, ABx, GAPS diet, food elimination. Our latest stool test also shows extremely high enterococcus and strep, and they are identified as quite problematic (Bioscreen test from Australia) vs Doctors Data which lists under good flora.
Our Aussie Dr also said, after talking to Dr Henry Butt, the microbiologist at Bioscreen, that enterococcus and strep are burrowing into the intestines and causing the damage to mucosa and therefore low SigA. They said imperative to treat with AMPICILLIN (I believe vanco and azithromycin might be alternatives, depends). They say very low dose, to BALANCE the flora, not to kill it. But in our case, we had nearly zero good E Coli, and also have to support E coli with Mutaflor. One child has this imbalance i found here on this website, who also use Bioscreen and Dr Butt. http://www.adhd.com.au/Intestinal_Dysbiosis.htm . We are right in the middle of treating with Ampicilin, so I won't know until we test afterwards (and how long it takes to repair SigA lining??) to see if this was actually the right treatment or not, but I will post if so. I have heard that lining can repair in less than 7 days?? But other Drs say years…
Also, we were told that the overgrowth of entero / strep causes the yeast overgrowth and yeast also destroys the SigA. Our yeast is in biolfim and no longer shows up on stool reports, but it is still there… when we do biofilm protocols we get die off. And imbalance of wrong bacteria changes ph of gut, which then prevents good bugs from growing…. then more yeast. If we balance the strep/entero, the theory is the yeast will die off by itself and everything will be back in order…………….. I only hope this is true! Please let me know if you hear anything differently. I only got this perspective after talking to the Australians. I am in Singapore and rely on American and Australian Doctors.