New Member- Information Overload

[LNN]

However, Kirvan and Cunningham in 2006 started investigating another effect which was that the antibody seemed to bind to the dopamine receptors rather than causing inflammation. So what they think is going on is inflammation is happening to the BBB -- allowing the antibodies to cross. But then once across, the antibodies are binding to receptors on the basal ganglia but not necessarily causing demylination or T-cell attacks. It's really hard to tell, but frankly I feel somehow better with binding rather than "attack". Certainly the lack of leisions as seem in ADEM, gives some comfort that the effect is reversable. Unfortunately, more research needed to see.

 

Buster

 

Then back to the original question - why does prednisone (and ibuprofen) help? Is it simply closing the BBB and thereby stopping additional auto-antibodies from binding to the Dopamine receptors?

[Buster]

Then back to the original question - why does prednisone (and ibuprofen) help? Is it simply closing the BBB and thereby stopping additional auto-antibodies from binding to the Dopamine receptors?

 

Yes. I'll probably sound like a broken record after a while (does anyone still use that expression anymore? )

 

PANDAS (like SC) is thought to be caused by 3 things

1. a genetic predisposition to an unusual immune response
   
2. the production of anti-neuronal antibodies
   
3. a breach of the blood-brain barrier that allows the antibody to reach neuronal tissue
   

So prednisone is affecting #2 (by immunosuppressing the production of more antibodies) and #3 (by being highly antiinflammatory).

 

I personally think that once the BBB is open there is sort of a feedback loop that keeps the antibody production going, so closing the BBB causes a break in the cycle (no research report here, just makes sense to me).

 

Buster

[matis_mom]

I am trying to convince my husband that we need to take Jake to the doctor. I completely agree with ALL your advice. He thinks that I overreact... I think he is in denial. He is concered about putting Jake on antibiotics all the time. He is the type that you don't fix the oil leak until the car is overheating and on the side of the road. Catch my drift.

 

Does anyone know the side effects or how I convince him that this is necessary. I want to catch the cycle early before Jake ends up as bad as he was in July... shane is the type that it has to be bad first. AHHH... so frustrating.

 

Anyone have thoughts on side effects of having your child on antibiotics all the time... data or research I can use as ammunition in my battle to get Jake the help he needs...

 

Also.. can anyone explain the why of using steroids after the antibiotics...?

 

Thank you so much for all your advice and help... It is crazy to think about how many kids are out there battling this and parents are completely unaware of PANDAS... I have talked with several people who had never heard of it.

Crazy stuff.

Hi Karmen,

I sent you a private message, check your box.

Isabel