smartyjones Posted April 6, 2010 Report Posted April 6, 2010 please excuse my poor scientific knowledge, but i think you'll get the gist. we know in pandas, there is an inappropriate response from the body to the strep bacteria. that then starts a cascade that somehow results in inappropriate function of the basal ganglia - yes? my understanding is that that is still not so well understood - whether it's an inflammation, interference and exactly what antibodies, enzymes etc are truly involved; opening of the BBB vs the presence of the problematic material. does anyone know what it is from lyme that results in the neurological issues? is it a similar malfunction of the immune system? does the bacteria itself attack the CNS? does the bacteria itself interact with the brain? is there a similar breach of the BBB with lyme? i guess it doesn't really matter for day to day management, but i was just thinking about it . . .
lyme_mom Posted April 6, 2010 Report Posted April 6, 2010 please excuse my poor scientific knowledge, but i think you'll get the gist. we know in pandas, there is an inappropriate response from the body to the strep bacteria. that then starts a cascade that somehow results in inappropriate function of the basal ganglia - yes? my understanding is that that is still not so well understood - whether it's an inflammation, interference and exactly what antibodies, enzymes etc are truly involved; opening of the BBB vs the presence of the problematic material. does anyone know what it is from lyme that results in the neurological issues? is it a similar malfunction of the immune system? does the bacteria itself attack the CNS? does the bacteria itself interact with the brain? is there a similar breach of the BBB with lyme? i guess it doesn't really matter for day to day management, but i was just thinking about it . . . The lyme spirochetes attack the CNS directly. The spirochete is a stealth pathogen that hides in the body and changes shapes to evade detection. This is why you need multiple antibiotics to corner it and kill it. In addition, when the spirochetes are killed by the antibiotics they release bio-toxins that can cause symptoms. This is why it is so important to know if lyme or other tick-borne illnesses like Bartonella and Babesia are triggering the PANDAS symptoms.
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