Yale/New study

[kim]

Don't think this has been posted yet?

 

http://www.ncbi.nlm.nih.gov/pubmed/20193755?dopt=Abstract

 

Elevated expression of MCP-1, IL-2 and PTPR-N in Basal Ganglia of Tourette Syndrome Cases.

 

CONCLUSIONS: Elevated expression of MCP-1 and IL-2 supports the possibility of chronic inflammatory processes in the basal ganglia. Replication of elevated expression of PTPR-N in TS specimen suggests that pathway(s) involving this molecule may be important in TS pathogenesis.

 

 

 

Buster, if you're reading I thought you might be interested in the "protein tyrosine phosphatase receptor-N," part in particular.

[Dr_Rosario_Trifiletti]

Don't think this has been posted yet?

 

http://www.ncbi.nlm.nih.gov/pubmed/20193755?dopt=Abstract

 

Elevated expression of MCP-1, IL-2 and PTPR-N in Basal Ganglia of Tourette Syndrome Cases.

 

CONCLUSIONS: Elevated expression of MCP-1 and IL-2 supports the possibility of chronic inflammatory processes in the basal ganglia. Replication of elevated expression of PTPR-N in TS specimen suggests that pathway(s) involving this molecule may be important in TS pathogenesis.

 

 

 

Buster, if you're reading I thought you might be interested in the "protein tyrosine phosphatase receptor-N," part in particular.

 

This fits with a general theory which I favor

 

Multiple infections triggers (strep, MP, Lyme-like, others) >> multiple Toll-Like receptor activation >> multiple signaling pathways >> increased NF-kB >> increased gene expression of pro-inflammatories

 

Slowly but surely the pieces of this PANDAS puzzle are coming together.

 

Dr. T